#181

The 17-alpha estradiol is likely to be absorbed transdermally, but I would suspect that most contaminants would not be. However, there is the issue brought up in some of the initial posts in this thread, that 17-Alpha estradiol is going to be, in most cases, manufactured with 17- beta estradiol and the trick in getting the 17 alpha version is the separation of these two chiral molecules. So there could very well be significant amounts of the beta version (i.e. regular “Estradiol”) that is very feminizing. So there is that risk to be aware of and test for if someone goes down this route.

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#182

Yeah I think I’d want to test it regardless of the route of administration.

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#183

How do we go about organizing this? Can we find a source people would be willing to put money towards ordering a sample from and testing, and then if it is good we do a group buy?

#184

Not sure why period are afraid of sourcing from China. Lots of great peptides and AAS coming from there. You just have to know the good sources.

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#185

This is a bit out of my wheelhouse, but here’s a few:

List of Vendors:

  • Shanghai Pemichem Biotechnology Co., Ltd.: Supplies 99% pure 17α-estradiol raw powder; based in Shanghai.
  • Shandong Octagon Chemicals Limited (Octagonchem): One of the largest manufacturers in China; offers kilos in stock for prompt shipment.
  • Zhengzhou Key-chemi Bioscience Co., Ltd.: Trader supplying 17α-estradiol; located in Zhengzhou.
  • Shanghai Jizhi Biochemical Technology Co., Ltd.: Offers 98% purity product at around ¥568/200mg; Shanghai-based.
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#186

Thanks. I guess the way to begin is to start compiling places that hold it, the link to their page and price information.

I’d also say finding out who is willing to offer a sample is good.

If we can get some good information compiled then it might be worth figuring out logistics.

I’ve emailed about 8 places. As of now I’ve got:
Shandong Octagon Chemicals Limited

Price: 1200 USD for 100 G including the shipping cost

I imagine there will be cheaper options.

I’ve also contacted Janoshik and asked if they’re able to test 17 alpha estradiol and find out purity and if there is 17 beta estradiol contamination.

#187

There’s actually a REALLY long list when I put it through the various ‘searching’ LLMs. I just wish I knew which suppliers already have a good reputation.

#188

Don’t trust LLMs for this. It needs to be done manually.

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#189

I think it’s worth pointing out that a number of papers incorrectly claim that 17α-E2 and 17β-E2 are enantiomers, which would imply that they have identical physical properties.

Enantiomers are inverted at all chiral centers, whereas 17α-E2 and 17β-E2 are only inverted at C17, which makes them diastereomers. Because of this they have different physical properties, which in principle usually makes them easier to separate, although in practice it can still be quite difficult.

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#190

I’m reaching out to see how many people are actually interested in participating in this group buy if we end up doing it?

I’m interested. Who else?

I’m still hearing back from different vendors.

I’ve heard back from Janoshik on testing, but maybe people know other vendors that might be more appropriate for this task.

My thoughts are we get samples from all vendors that seem good, send those to a testing facility. The one that comes up best we then do a group buy. We figure out how much of the molecule everyone wants and make the order.

I’ve never done a group buy though, so I’m not 100% sure on the logistics of this from that point onwards so hopefully someone more experienced can help explain this process.

#191

Are you in Australia? That would complicate things greatly. Australian customs is notorious.

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#192

Yes I agree. If enough people are interested we may be able to have someone else actually ship things out. I would rather not run it all through Australia any more than necessary.

#193

Premenopausal women are less sensitive than men or postmenopausal women to acute kidney injury (AKI), which is characterized by renal tubule ferroptosis and nephron loss. Tonnus et al . uncovered two mechanisms through which estrogen limited ferroptosis of renal tubule cells in female mice after ischemia-reperfusion injury (IRI). Renal IRI induced more tubule ferroptosis in male and ovariectomized females compared with intact females, and treatment with a pharmacological inhibitor of ferroptosis reduced kidney damage in male, but not female, mice. Two hydroxylated derivatives of 17β-estradiol, 2OH-E2 and 4OH-E2, protected cultured cells from pharmacological induction of ferroptosis, acted as radical-trapping antioxidants in vitro, and were enriched in the renal tubules of female mice. In renal tubules explanted from mice after IRI, 2OH-E2 protected male tissues against cell damage and death but did not further protect female tissues. Genomic actions of estrogen also contributed to its protective effects, because female mice lacking the intracellular 17β-estradiol receptor ESR1 showed more tubule ferroptosis and kidney damage in response to renal IRI compared with wild-type female mice. ESR1-mediated genomic estrogen signaling reduced both the turnover of the endogenous antiferroptotic molecule GSSH and the biosynthesis of ether lipids, which are substrates for peroxidation and increase the susceptibility to ferroptosis. Experiments in male and ovariectomized female mice and in renal biopsies from male, premenopausal female, and postmenopausal female patients were consistent with these protective genomic effects of estrogen being absent in male and postmenopausal females. Thus, estrogen protects against ferroptosis and AKI through both nongenomic and genomic mechanisms.

#194

Count me in. Do we have a price range for the testing?

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#195

Janoshik said $500.

I’ve not had enough people express interest for this to be viable.

#196

Greetings. I am wondering if you are still doing the 17 Alpha estradiol with the transcutaneous Ell-Cranell Alfatradiol cream and ethoxydiglycol? If you are, would you be so kind to update your results after this lengthy time period? Any good or poor results? Feminization? Thanks.

#197

Has anyone in these boards used (or is using) 17-Alpha Estradiol, and if so how would one source it?

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#198

That’s exactly what I am trying to learn. From my reading here, a hair loss solution available in Europe (but not the USA) can be purchased. It can be mixed with another chemical to improve transcutaneous absorption. I have placed an order with 24Chemist and am awaiting shipment. I will post here when/if I receive it.

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#199

Be sure to check this thread also: 17 Alpha Estradiol: Use and Dosing Experiences

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#200

I received the Pantostin with 0.25% Alfatradiol yesterday from 24Chemist in Portugal. It took only 8 days from the time I placed the order. They ship to US only with Fedex International Expedited. No tariff paid. This product contains only the alpha isomer. Since I have some male pattern alopecia I will begin applying to my scalp. I’ve ordered transcutol as well (delivery pending) that will enhance transcutaeuous absorption.

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