#21

Yes :slight_smile: I think we need one more person and then we’re ready to go!

1 Like
#22

F it…. I ordered a gram from UmbrellaLabs. Added a gram of ibutamoren to my order and with 10% off from a discount code I found online, another 10% off from orders over $100, and 5% off from paying with a US bank, the total came to $100.58 for them both. Pretty good!

What made me pull the trigger is the batch by batch certificate of analysis. They use mass spectrometry too from an independent U.S. based lab. For details:

I’ll tell you if it feels like anything at all. It’s a gram. Won’t kill me. I’m curious if it does anything. And I’m pretty inured to placebo.

5 Likes
#23

I’m interested in all user reports at this point due to how little is known on human effects.

#24

Excellent that’s 3 people! I’m just waiting to hear back from Ora about doing the crowdfunding on their website. Might have to wait until the beginning of next month but we will see. As long as people are willing to wait a bit longer then it is ok.

#25

4th person here - happy to contribute US$ 100. I guess that means we’re there? All I need is details on how to make payment to Ora Biomedical…

3 Likes
#26

Amazing, thank you for supporting this.
I’m going to email Ora again and inform them that we have 4 people willing to contribute $100US each. Maybe they can expedite this before the official launch of the new fundraiser capabilities on their website.

I will report back when I hear more.

2 Likes
#27

@medaura I’m curious - how will you decide things like how to take it, dosage, frequency etc? Wild-ass-guesses? Or do you have a protocol for how to approach it? Kudos for having a go!!

2 Likes
#28

I did a Deep Research prompt on ChatGPT to learn more about the substance and it estimated that 5mg a day would possibly be a reasonable dose for humans. Obviously this is not medical advice, or something I can recommend humans do.

If I were to use this substance I would use it in the evening. I suspect combining it with a high dose of melatonin would produce even more favorable effects.

I am incredibly curious on hearing anecdotal reports from longevity enthusiasts who are willing to use the substance.

2 Likes
#29

I’m looking forward to seeing this move forward. :slight_smile: Thank you so much for posting about it here, I would have missed it otherwise. No matter what comes out of it, it seems like a very interesting substance and it’s a shame we don’t have better data yet.

2 Likes
#30

I am not quite sure why that would be. I don’t intend trying this although I do intend continuing with my over 1,000mg of melatonin a night.

1 Like
#31

Supposedly IPAM does not bind melatonin receptors, so it doesn’t clash. IPAM can be stimulating to some, melatonin will balance that. IPAM has a longer halflife than melatonin.

High dose of melatonin helps you sleep in case IPAM interrupts sleep for some, and you get the benefits of IPAM during the night when you’re not in need of ROS.

Just a theory.

1 Like
#32

My main reason to take melatonin is to protect mtDNA. IPAM may also reduce harm to mtDNA. Melatonin probably helps with the autonomous nervous system, however.

#33

I plan on interrogating ChatGPT to get to some reasonable guesses. The problem might be very crudely logistical — what’s the minimum sized scooper I can get to be able to consistently pull out the same (or almost same) amount each time? I plan on taking it for about a month, unless I get any unwelcome effects. So that’s 33 mg a day, unless I titrate up to it, which I should. Of course this is all preliminary wild ass guessing. Lately I’ve been a big adherent to just-in-time learning when it comes to practical considerations. So I’m sure I’ll get a lot more serious once it’s in my hands. But I don’t want to pair it with melatonin or anything else just so I can remove noise and be sure of what’s giving me any effect.

2 Likes
#34

@katiii @AustraliaLongevity @KiwiGuy and everyone else, if you find any pointers re: dosing, please send them my way as I’m investigating all possibilities at the moment. Even anecdotal accounts, maybe especially anecdotal accounts.

And what’s with an Aussie and a :kiwi_fruit: lounging in the same thread? :wink:

#35

Get milligram scale. A liquid solution with dropper would likely be the easiest way to dose. Unsure if it would degrade quickly like that. I’d only make a few days worth at a time like that.

Absolutely titrate.

If you have powder there is no need to take it all, it won’t go off. I believe smaller amounts would be better. Start 1mg, titrate. Has decently long halflife.

Good call. That was just a hunch of mine.

Be careful.

2 Likes
#36

I also suggest to be really careful. You might wanna wait, as we wanna do the worm bot test shortly and this will give us more data, without risking our health. People on reddit took way less than 33 mg, more 1-2 mg - And still felt an effect.

3 Likes
#37

Good call on the milligram scale. Just ordered one on Amazon. Who knows, you may be right that it works even better with Melatonin, but I’ll go on full pill holiday for a while to rule out interactions and any effects from other supplements.

#38

You are right. Maybe I should have put the $100 towards the wormbot but it seemed like a foregone conclusion that you’d get it funded any minute so I wanted to add a human test subject, since it’s still quite a leap from a worm. Feel free to send me any discussions on Reddit etc. I’m sure I’ll find them when I look but it could spare me some digging. If it turns out that it kills worms faster than placebo then I’ll not be a happy camper for going wild on it. For sure I’ll titrate and maybe stop at the dosage where I feel an effect. The studies on rats have them taking 0.3mg/kg of body weight, I believe, so I am a bit skeptical of effects being felt at such tiny dosages but that’s why I’m going on pill holiday, so I can pay closer attention to my brain and body and detect any change.

Edit: they used 0.5mg/kg. Translating to humans would take a much bigger dose but then again adjustments would come into play for metabolism etc. At any rate I’ll titrate up from very little.

#39

If you search the chemical you can find some anecdotes but my post here sums all main points they mentioned.

Any cool stuff you find post here!

1 Like
#40

It seems we have UDS400 promised now (including USD100 from me) so that is potentially right. However, although the target is good (Complex 1) this has been around for 15 years now and although we don’t have any research evidence one would have thought if someone tried it and got no benefit we would know. Sadly it is hard to get negative results published even though they are important.

Hence I have not bought any myself and although I am not a fan of worm results I am happy to fund a worm test.

2 Likes