#21

Beth, may I ask which choline supplement you are using?

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#22

I bought Life Extension Citicoline (CDP-Choline). I don’t remember why I chose this one! I imagine I read about that form on here.

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#23

Life Extension Citicoline is a great choice! CDP-Choline is metabolized differently than choline salts like bitartrate, which tend to raise TMAO the most. From what I’ve seen, studies on TMAO and choline supplementation almost always use choline bitartrate, so the risks might not translate directly to CDP-Choline.

Regardless, mitigating TMAO makes a lot of sense. Supporting a healthy gut microbiome with probiotics and prebiotics can help reduce TMAO production, and omega-3s like DHA and EPA may counteract some of its potential cardiovascular effects. A fiber-rich, plant-forward diet is another great strategy to keep TMAO in check.

Anecdotally, I have seen the bloodwork of someone who used significant amounts of Alpha GPC and there TMAO was undetectable.

I’ve been mindful of TMAO as well, but I feel good about CDP-Choline, especially considering its cognitive benefits and different metabolic pathway.

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#24

CDP-Choline was found to mitigate COVID infection also.

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#25

I really appreciate you sharing all of this.

I don’t know much about alpha GPC. Would you consider half of each compound for me or just stick with what I’m doing? THX!

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#26

In my experience, CDP-Choline (Citicoline) and Alpha GPC have very similar effects, but there are key differences. Alpha GPC is faster-acting and provides a direct boost in choline availability, making it better for immediate cognitive enhancement or physical performance. On the other hand, CDP-Choline has a more sustained effect and provides both choline and cytidine, which converts to uridine. Uridine plays a role in synaptic plasticity, neurogenesis, and brain repair, so CDP-Choline might have additional long-term benefits. If you’re looking for a quick choline boost, Alpha GPC might be the better choice, whereas CDP-Choline may offer a more balanced approach with potential neuroprotective effects.

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