#21

It was Cerebrospinal fluid rather than spinal fluid (the same thing, but to emphasise it goes into the brain). The pineal melatonin is injected into the CSF. I think some of that melatonin (which washes into the brain when the blood pressure goes down as people go to sleep) is metabolised, but as an anti-oxidant rather than the way the liver clears melatonin out of blood.

When you take melatonin into the blood some goes into CSF, some gets metabolised by the liver and some goes into other cells. I don’t think the melatonin that goes into other cells is metabolised per se. I think it ends up in the mitochondria acting as an anti-oxidant. Hence it will have a reducing effect until it is used up. I have no idea of the rate at which it is used up.

There is an argument to take melatonin during the day. I have only done this when drinking, however. I may try it more when not drinking.

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#22

I would not presume to offer clinical advice @Justin but your wait time makes me wonder if it is worth pursuing other options to get a MRI to see if the tumor is isolated. Treatments are very good now, even with advanced PC.

In my view, the USPSTF is unethical and incompetent, They should be disbanded and in the meantime ignored. In the US, they seem to serve only the insurance industry. Their latest stupidity is to recommend against screening for vitamin D levels on the basis – wait for it – that it has no demonstrated benefit in assessing bone integrity. The USPSTF continues to be directly responsible for human suffering.

On PSA screening, switching to the PSA Total+% Free test significantly increases the usefulness of your findings. If they did not run this test on you Justin, you may want to do it on your own. The cost at Life Extension is minimal.

Several years ago, my PSA had crept up to a little above 3.0. Because my father died of metastasized PC at age 86, I began researching interventions to reduce it and switched to the more comprehensive PSA test designed for people who had prostatectomies. I now conduct this test annually. Below is my latest test result from blood drawn this Tuesday.

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#23

For those recommending radiation or contemplating it for themselves, I recommend investigating Proton Beam treatment rather than the ubiquitous ionizing radiation that does so much collateral damage. Unfortunately, there are only a handful of proton treatment centers in the US.

If ionizing radiation was my best practical choice for some reason, I would follow up aggressively to reduce all of my inflammatory markers to basement levels. Even though the PC treatment was “successful,” residual post-radiation vascular inflammation caused a massive blood clot that broke free and killed a good friend of mine. His physicians didn’t even mention the risk to him.

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#24

I don’t give medical advice to others, but here is what i did when I had a high PSA. I had a 4kscore blood test. Developed in Sweden, this is a much better test than standard PSA test and gives an accurate measure of your Gleason score. I also had two tests: a three dimensional Doppler ultrasound and an MRI of the pelvis. These two tests can show where Prostate cancer is exactly (standard biopsies only see one side of the prostate). I also went on a keto diet with very low carbs and high fat though I did eat salads with broccoli sprouts (high in cancer inhibiting sulphurophane). The goal is to reduce insulin, which is the trigger to cancer cells to absorb glucose (even if you stop all carbs your liver will produce glucose by gluconeogenesis).
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4444768/

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#25

@Uppereast69 I couldn’t tell if your intervention helped or not.

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#26

It is impossible to use ionizing radiation to get rid of tumor cells without extensive collateral damage.

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#27

That’s what I said, “. . . rather than the ubiquitous ionizing radiation that does so much collateral damage.”

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#28

I agree that it is much better, but there is still significant collateral damage with any kind of beam-forming ionizing radiation.

“Compared with traditional radiation, protons have unique properties that allow doctors to better target radiation to the size and shape of the tumor. The proton beam kills the tumor cells and spares more of the surrounding healthy tissue.”

Based on what I could find, there is no clear consensus on the most effective treatment for prostate cancer. There are just too many variables.

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#29

I don’t know what the exact percentages are, they likely vary with context, but proton treatment ionization is relatively de minimis when compared with x-ray treatment. Protons are delivered as particles and therefore can be focused into a much narrower beam (less collateral damage) which can be targeted by depth (minimal collateral damage in transit), stop when they hit the cancer cell (less downstream collateral damage), have a greater chance of killing the cancer cell cf. damaging it as x-ray does, and are molecularly stable (no exchanges). X-rays are delivered as waves in a wide beam. Best case, they damage a large area before, broadly around, and beyond the tumor site. Beyond that, I guess one would have to define what they mean by ‘significant’ but if you were to compare notes with people who have had proton and x-ray treatment in the same area for the same disease, you would not likely to come to the conclusion that both caused significant collateral damage. I think it likely that x-ray treatments are defended in some combination because a proton machine is not available and/or the institution wants to retain the revenue.

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#30

After practicing Calorie restriction for six months and receiving incredible benefits, decided to try Rapamycin. The one thing I noticed immediately within a month was at times an overwhelming sense of well-being and also just a general better mood.

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Anti-aging Benefits of Rapamycin, Personal Experiences (part 2)
#32

I’ve listened to your excellent podcasts so I know you are far too clever to think that what I described above is any kind of intervention like Niraparib to deal with prostate cancer. My only point is what I did when I had a high initial PSA score as described by the OP. The result was that I probably didn’t have PC (can’t ever completely rule these things out at my age). I stayed on the diet for about a year. At my next PSA test it was normal (for me). I still eat salads with broccoli sprouts as often as I can.

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#33

What did the U/S and MRI show?

#34

As I said, no evident PC was seen in either test.

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#35

Look again at DAV therapy on this site. Rapa + DAV periodically should be a good barrier against cancer.

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#36

Many thanks to all of you. I’m an RN contracted to US/DOL. I oversee Workers’ Compensation cases on injured Federal workers, USPS, Homeland Security, FDA, and VA employees. I’ve been neglecting my ~40 cases, so I’ll come back next week to review what everyone wrote.

A few sort responses: KarlT, I have one palpable ~11-16mm tumor on the R side of my prostate, but the real kicker is a PSA of 54. Any PCa w/ a PSA of over 20, automatically becomes hi risk. It is sort of odd, and I would think that I’d have a MRI right away, if only for biopsy targeting. Biopsy is scheduled out several weeks–which does not make me happy.

Yes, being an RN that oversees injured workers, that is so very common. I was RN for a large Sysco Unit (the huge wholesale grocery corp) when a worker decided to teach a 100lb bag of potato’s who was boss. The potatoes won. The fellow tore his biceps muscle completely off his forearm. The path from MRI > Surgery normally takes about 3-7 weeks. Had I allowed that, there is no question that he would have lost at least 1/2 of his biceps strength, forever. I had him under the knife in 5 days, and he recovered handily. I’d guess that in about 80% of cases, he would have recovered but with great loss of biceps. Time, sometimes, is of the essence, as in that case, sometimes not, for instance the same injury with the tear at the shoulder, even 7 weeks to surgery would have made little difference.

I need to jump back into those cases and so can’t spend a long time looking at posts and researching.

But, yes, I’d prefer MRI > biopsy > one of the specialized CT scans to look for distant metastasis, all in a week or two, not two months. It rather feels like watching racoons eating ears of corn in your corn field and having someone say, “I’ll trap them in a month or so…”

DeStrider’s immunotherapy is interesting. However, PCa, for some reason seems to be able to circumvent that method. At this point I know little but the PCa “gates,” the t-cells that want to destroy the Ca cells. I do remember that very low carb diet (keto) in one study prevented the PCa cells from locking the T-cells out. I like that, and will look into that. Co-incidentally, over the past year I have water-fasted a total of 44 days (mostly 2-3 day water fasts). I find it very easy. After finding the PSA of 54 I’ve done a 4-day water fast and now am on a 10g carb, high protein.

Everything that I have read/heard is that I should continue my 6mg/1x/week Sirolimus, and I shall do that.

I got “my legs back,” last July w/ a new hip replacement and have loved the new ability. Even with 44 days of fasting I’ve gained just about 1" on my biceps (co-incidentally losing 54lbs) and quads (I’ve always admired Agetron’s biceps).

Again, to all who have responded, thank you.

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#37

Yikes, it’d take me a week to read the patent application. N=1 on the disappearance of a prostate cancer nodule, I’ll have to spend a few hours looking this over, thank you.

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#38

Remember the DAV was invitro (petri dish) study + very informal 78 yo subject… That said, very low risk therapy.

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#39

I am using.a device 1-2 hours a day called AquaCure it produces hydrogen/oxygen or browns gas. I drink 1-2 liters of water daily. George Wiseman is the inventor, our bodies are 84% hydrogen and oxygen. I started using this device 6 months ago, my skin is smoother, I feel refreshed after an excellent night sleep. The point is my exterior shows healthy signs from consistent use and my internal organs will benefit too. I did a podcast with George and he mentions it has supported people facing cancer. It has a patent in three countries. You could listen to the podcast and decide if you want to investigate further. Livingwellagingbetter.com is my website and it is episode three. I have been in the healthcare industry for 25 years and I am 69 years old. I believe there is more than one way to skin a cat.

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#40

Yeah Keto does not have to include Large amount of red meat. Avocadoes, Nuts/Almonds/Walnut, Extra Virgin cold extrafcted olive oil. Wild Alaskan sockeye salmon/Sardines etc etc.

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#41

Take a look at the studies on Salvestrols and cancer, particularly prostate and bladder cancer.

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