I for one definitely have to get up to pee at night more often when taking empagliflozin (and have to pee more often in general due to its diuretic effect).
2 Likes
LukeMV
#42
My experience as well now having been on it for two years. I still have to use the bathroom a lot but I also eat a lot of fiber so I think it’s a combination. But much less gas than at the beginning for sure.
1 Like
I would guess he means mitochondrial fusion….they combine resulting in fewer larger mitochondria and is related to increased mitophagy.
1 Like
I just assumed that two things happen. One, a hormone (vasopressin) is released at night that limits how much urine is produced, and so you don’t have to wake up as often to urinate. But also, the SGLT2i causes glucose to not be reabsorbed into the bloodstream, and instead, the kidneys move the glucose to the bladder before excreting from the body. Therefore, the SGLT2i should have no problem acting as usual on the kidneys at night, it just gathers excess glucose concentrated in the bladder, so in the morning you get rid of it as usual, no problem, and the mild diuretic effect can be countered by the vasopressin. I don’t know if that’s exactly how it works, but I can see a plausible mechanism at least. Bottom line, the SGLT2i park the excess glucose in the bladder at night, and keep it there until the vasopressin wears off?
1 Like
