#499

That’s an interesting suggestion on the gut microbe effect being the longevity mechanism for arcabose. If the arcabose mechanism was only preventing blood sugar spikes, I was wondering how translatable mice studies are to humans, because Dr. ChatGPT says that mice metabolize carbs more quickly than humans and are more subject to blood sugar spikes. So presumably we sustain less metabolic damage from blood sugar spikes than mice.

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#500

Unfortunately, the benefits of acarbose in the human gut are far less than in mice. Our gut microbiota can degrade acarbose, and with long-term use, the gut microbiota will eventually metabolize it on its own.

#501

Yes that’s it. They also have a few new blends that are lower dose and less expensive. These may be adquate if your goal is only gut health and not glucose control

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#502

What is the optimal dosage for life extension do you guys think?

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#503

I used the upper daily dosage recommended in my country wich is 200mg 3 times a day during meels. I don’t see more sides with that dosage compared to 50 or 100mg with each meels. I just fart a lot. Quite funny with male friends. (lol)

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#504

The ITP studies suggest up to 800mg per day may be better for longevity for humans… the closer to that you get, the better (I suspect).

The best data we have on acarbose and longevity is the ITP study data. See these calculations in this thread (first post): What is a good initial dose of Acarbose to combine with 5mg of Rapamycin taken once a week?

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#505

Wow, I need to step my game up! Jk I wouldn’t use 800mg per day. That would cost an outrageous amount of money too. I have gone up to 200mg per day (50mg with each of my four meals) thinking it was a lot but I guess not. I believe the max dose for diabetics (which I’m not) is 300mg per day.

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#506

Not really.

Here is my recent pricing from Maulik / Shreej Impex:

Glucobay 50 mg ( please note 100 mg is discontinued) - 500 tablets = 95$

Cost per 50mg tablet: $0.19

Cost for 800mg per day: $3.04

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#507

The place I get it from is a little pricier but even $3 a day as yours says is still $90 per month, so that’s a lot to do for a whole lifetime

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#508

I know you live in California where $90 a month is nothing but for the rest of us, that is quite a lot of money.

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#509

Coffee at Starbucks is more than $3 no matter where you live and it’s not a good coffee.

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#510

I don’t know anyone who goes to Starbucks every day.

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#511

I think im taking the money I use for novos to possibly do this (around 90 a month).

Just more secure with this now

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#513

You clearly don’t know many women in their 20s and 30s then :rofl:

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#514

Interesting. This is new to me.

Still, if acarbose is delaying small intestinal carbohydrate metabolism, this should be very beneficial even if microbiota in the colon subsequently metabolize the drug. I would think that the majority of the microbiome benefits come from delaying carbohydrate degradation, rather than direct effects of acarbose on bacteria.

If this is really a concern, perhaps it would be beneficial to cycle between acarbose and miglitol to prevent the microbiome from adapting?

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#515

Do you have a source or is this a hypothesis?

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#516

Hello and good day. My lab rat takes 25mg tablets twice a day… with breakfast and dinner.

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#517

Summary: Neural stem cells, which create new neurons in the brain, become less active with age due to elevated glucose levels. Researchers found that by knocking out the glucose transporter gene GLUT4 in older mice, they could significantly increase the production of new neurons.

This discovery opens up potential pathways for both genetic and behavioral interventions to stimulate brain repair, including the possibility of a low-carbohydrate diet. The findings could help treat neurodegenerative diseases and aid in brain recovery after injury.

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#518

I don’t know, several places they mentioned a low carb diet may be an answer. It may be. But I have not found a low carb diet to be a solution to the problem of a high fasting glucose. My liver just cranks out too much glucose.

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#519

The worst “pair” of words in the English language = “Up to.”

“We’re giving you a raise, up to $200 extra per week.”

Employee, after being paid said: “But, but I only got an extra $2 per week.”

Employer: "Well, that’s in the “up to range.”

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