#46

Thanks much! After getting the bloodwork done, I will add these to my longevity stack and monitor. Fortunately, I want to cut back on wheat anyhow. :slightly_smiling_face:

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#47

acarbose only needs to be taken with a meal, if that meal has carbs in it. if not, then I dont think there is any need. Acarbose doesnt last very long, hence the need to take it at the begining of every meal (up to 3 times a day)

#48

Didn’t you post a study a few months back suggesting that empagliflozin worked better with nightly vs morning dosing?

#49

I think it was an idea thrown out in a discussion, but I’ve not gotten around to testing it at the same time I’m using my CGM. Perhaps someone else has tried it?

#50

Since I use time-restricted feeding, usually a 5-6 hour window an empagliflozin has a half-life of about 12 hours, which also begs the question of how much I am accumulating in my system with daily dosing, I take it ~1 hour before my first meal of the day.

“The total body clearance of empagliflozin is 10.6 L per hour and the expected half-life of empagliflozin is around 12.4 hours. The long half-life of empagliflozin permits once-daily dosing.”

#51

Acarbose’s longevity capabilities is not only from preventing blood sugar spikes after meals I think. Probably more important is its gut microbe effect. The increase of butyric acid is noticeable after very short usage, and other SCFA’s for that matter. There is a reason why almost all centenarians has very healthy guts, it makes you live longer and healthier.
If you have bad reactions from Acarbose that you can not tolerate, I suggest to try something called ButyrAid from NutriCology. I am using is once a day, with Acarbose once a day. It is fantastic. Immediate results. ButyrAid 100 Tabs

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Acarbose for healthy person? WHY?
#52

I think that you may be right . The alterations in the microbiome may be the biggest benefit.

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#53

FYI:

Metformin, acarbose, and sitagliptin monotherapy effectively decreased fasting and postprandial blood glucose levels (p<0.001). Acarbose group displayed specific cluster and enterotype mainly composed by Ruminococcus 2 while Lactobacillus was the dominant bacterium in the enterotype of the other three groups. The relative abundance of genera Ruminococcus 2 and Bifidobacterium was dramatically higher in acarbose group. Metformin and sitagliptin increased the relative abundance of genus Lactobacillus. Metagenomic prediction showed that the functional profiles of carbohydrate metabolism were enriched in acarbose group.

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#54

Goran, have you looked at sodium butyrate? It contains a full 600mg butyrate per capsule (vs 100mg for the calcium/magnesium butyrate) and doesn’t have all that extra ca/mg (of course, it does have sodium). Anyway, seems like a much more effective and cheaper way of getting a much larger dose of butyrate:

Gut Health Supplement 60 Caps - Butyrate + Sodium | The Ultimate Postbiotic | No Bloating | No Gas | Great Poops | Supports Healthy Digestion | Leaky Gut Repair | No Filler or Additives by BodyBio Amazon.com

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#55

Very interesting.
All 3 drugs reduced postprandial glucose levels.
They also all had significant effects on the microbiome.
Seems that acarbose May be superior regarding the gut effects in diabetics.
However, I don’t like the fact that acarbose reduces the microbial diversity.

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#56

So for those taking acarbose, what is your dosing?

#57

I have looked at sodium butyrate and magnesium butyrate. I will try the sodium variant next time. I like to experiment. Will put an order in for this.

#58

Thank you for that, I will research it

#59

I’m not taking it yet as I only heard about it today but if anyone is taking it please let me know your dosing and reason for taking it, ie Metformin not working etc
Thank you

#60

Acarbose is certainly cheaper than Rapamycin!

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#61

Yes, but they are both very cheap and and easy to buy from India if you live in the U.S.

I am waiting for more confirmation that rapamycin does anything but retard aging a little. I haven’t seen any “miracle reports” that rapamycin extends lifespan in humans. Maybe a little too early to tell, but remember those lifespan improvements were reported for Metformin because many people even though technically sick had been taking it for a long time. I have seen no similar statistical reports for rapamycin even though many people have taken it since 1999 when it was first approved by the FDA for kidney transplants. But, even though it has only been a little over two decades if was a “miracle” drug we should have started to see some results in human life extension.
My own results from rapamycin are a phenomenal improvement in my skin condition.
I have suffered from chronic actinic keratoses for many decades. Rapamycin has reduced my visits to the dermatologist to zero. This is not subjective and I can document the results. Also, rapamycin has reduced my age-related arthritic joint pains to near zero.
I would describe myself as pain-free.

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Animal trials are all on much higher dosages than we are taking
#62

It would take an absolute miracle drug to get any meaningful life extension in renal transplant patients. They have multiple co- morbidities , but perhaps those on rapamycin live longer than the groups on cyclosporine. I have no idea.

Is there good human data on metformin and life extension ? I’m referring to non diabetics.

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#63

Perhaps more so than most supplements. In any event, it does seem to reduce all-cause mortality in non-diabetics.

“Metformin reduces all-cause mortality and diseases of ageing independent of its effect on diabetes control: A systematic review and meta-analysis”

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#64

I know that in diabetics it gave increased longevity compared with non diabetics.

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#65

Unfortunately no studies with healthy study subjects. When Metformin received so much attention for its anti-cancer effects, this was seen in patients suffering from T2D with low HDL-cholesterol. Difficult to draw any solid conclusions from studies that show results in such a specific group of patients. Wish the TAME trial would start already.

https://diabetesjournals.org/care/article/34/2/375/39232/Low-HDL-Cholesterol-Metformin-Use-and-Cancer-Risk

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