#56

So for those taking acarbose, what is your dosing?

#57

I have looked at sodium butyrate and magnesium butyrate. I will try the sodium variant next time. I like to experiment. Will put an order in for this.

#58

Thank you for that, I will research it

#59

I’m not taking it yet as I only heard about it today but if anyone is taking it please let me know your dosing and reason for taking it, ie Metformin not working etc
Thank you

#60

Acarbose is certainly cheaper than Rapamycin!

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#61

Yes, but they are both very cheap and and easy to buy from India if you live in the U.S.

I am waiting for more confirmation that rapamycin does anything but retard aging a little. I haven’t seen any “miracle reports” that rapamycin extends lifespan in humans. Maybe a little too early to tell, but remember those lifespan improvements were reported for Metformin because many people even though technically sick had been taking it for a long time. I have seen no similar statistical reports for rapamycin even though many people have taken it since 1999 when it was first approved by the FDA for kidney transplants. But, even though it has only been a little over two decades if was a “miracle” drug we should have started to see some results in human life extension.
My own results from rapamycin are a phenomenal improvement in my skin condition.
I have suffered from chronic actinic keratoses for many decades. Rapamycin has reduced my visits to the dermatologist to zero. This is not subjective and I can document the results. Also, rapamycin has reduced my age-related arthritic joint pains to near zero.
I would describe myself as pain-free.

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Animal trials are all on much higher dosages than we are taking
#62

It would take an absolute miracle drug to get any meaningful life extension in renal transplant patients. They have multiple co- morbidities , but perhaps those on rapamycin live longer than the groups on cyclosporine. I have no idea.

Is there good human data on metformin and life extension ? I’m referring to non diabetics.

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#63

Perhaps more so than most supplements. In any event, it does seem to reduce all-cause mortality in non-diabetics.

“Metformin reduces all-cause mortality and diseases of ageing independent of its effect on diabetes control: A systematic review and meta-analysis”

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#64

I know that in diabetics it gave increased longevity compared with non diabetics.

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#65

Unfortunately no studies with healthy study subjects. When Metformin received so much attention for its anti-cancer effects, this was seen in patients suffering from T2D with low HDL-cholesterol. Difficult to draw any solid conclusions from studies that show results in such a specific group of patients. Wish the TAME trial would start already.

https://diabetesjournals.org/care/article/34/2/375/39232/Low-HDL-Cholesterol-Metformin-Use-and-Cancer-Risk

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#66

The ITP released a new paper on September 30 about Rapamycin and Acarbose.

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#67

Does anyone have a link to the actual released paper? I can’t find it>

#68

I believe the link to the paper is at the beginning of the video. It seems the numbers aren’t as impressive when the short lived controls at the University of Texas are removed.

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#69

Here is the paper New Paper: Lifespan Benefits for the Combination of Rapamycin plus Acarbose in mice

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#70

Acarbose was only effective for male mice. I tried to find an information of the effect on females/males people and only found one study : Li J, Li J, Shan Z, Yang W, Liu J, Tian H, Zhou Z, Ji Q, Weng J, Jia W, Lu J, Liu J, Xu Y, Yang Z. Gender-differential effects on blood glucose levels between acarbose and metformin in Chinese patients with newly diagnosed type 2 diabetes: a sub-analysis of the MARCH trial. Endocr J. 2021 Jan 28;68(1):69-79. doi: 10.1507/endocrj.EJ20-0006. Epub 2020 Sep 10. PMID: 32908086.
Are you aware of any other studies on the effect of Acarbose for female patients compare to males?
Does it even make sense for females to take Acarbose ?

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#71

Does Acarbose interfere with the benefits of exercise like metformin ?

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#72

No - there is no evidence of that.

#73

Thanks so much as I want to add Acarbose to my after workout whey drink

#74

Ah - I spoke too soon. Just found this study out of China on people with diabetes. This is the only study on this that I’ve seen so far. Not sure if it applies to healthy people, but something to be aware of:

I will track my lean muscle mass over time with DEXA scans anyway, so I’d see if this is an issue with me. I’m also (independent of this study, for other reasons) increasing my workout schedule from approx. 4 hours/week towards 6+ hours/week.

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#75

Thanks, I guess I´ll try to at least wait for a few hours after my workout to take acarbose. On non exercising days I´ll combine acarbose with metformin

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