Tons of people are going to be duped into believing moderate alcohol intake is good for you. This is just sad.

Next they’ll be saying a cigarette a day is good for you. This backsliding is shameful.

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This is new to me. Apparently very expensive, but interesting:

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We are in our 80s , we drink 2 half glasses a wine every night with dinner( husband drinks red I drink NZ Sauvignon blanc) we have been doing this for 13 years. I don’t know what a unit is but 2 half glasses should be regarded as 1 glass ?
We eat only organic fruit and veg, grass fed meat and wild caught fish. My husband works out 4 times a week ( own gym) and walks twice a week. I don’t exercise but walk at least 3,000 steps a day in my home doing housework etc, walking the pooch too. We both play golf at least 4 times a week, often having to walk because of the wet conditions in Florida .
We have full panel bloodwork done every 4 to 6 months . My results indicate I am 10/15 years younger than my age if I can get my glucose lower ( 124 non fasting last time) I am pre diabetic. My husbands bloodwork is excellent but takes blood thinners for elevated blood pressure. So, at our age and the fact that we are very active and no decline in memory ( we take supplements and Rapamycin) I think we will continue to enjoy our 2 half glasses of wine . Neither of us ever have any desire to drink alcohol during the day .
Thank you all for your comments , very interesting

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Non fasting glucose will depend on when and what you eat and the timing of the blood draw. It also metabolises slowly in a blood sample.

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Seems both of you are enjoying healthy lifestyle and aging well. 124 not fasting imo is pretty good. And golf 4 times/week is impressive! I remember how tired I was after just one round of golf.

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I don’t feel so much tired after golf but I’m soaking wet from the humidity, I don’t tolerate the humidity very well and we have a misting system installed all around the golf cart to keep me from collapsing from the heat, also I use a Chilly Cheeks ice pack that really helps. .i have started to learn to play the keyboard too and after 3 months I can play lots of songs from a great teaching system online. I have low vision so I need very large print and this online course is perfect for me , I think keeping busy and learning new skills keeps people young .

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I don’t know how you monitor your glucose but what helps me is wearing FreeStyle Libre 3 which I get at Costco. My insurance doesn’t cover it bc I don’t have diabetes, but my doctor still sent a script per my request. It helps me to make better choices about what I eat and drink and at what time. It’s $30 for 15 days.

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Thank you for that, I tried the monitor in my arm and it went off like a emergency alarm while I was resting, frightened the life out of me, then I couldn’t get the dam thing off, never again. My sugar levels have fluctuated between 118 to 124 for years. I eat everything low carb and no sugar which makes life very difficult, my insulin is my worry, it was at 5.5 6 months ago, last week it had dropped to 0.5 that doesn’t make sense, my A1C is 6.2 slightly better than the previous panel results

I tried to send a screen shot of my glucose range but I cannot see how to include it. I use a watch to check my glucose my but they are not reliable

Dee, to add an image to your post here just click on that little box with an arrow pointing up (see the right side of the image below) when you create a new message - and then upload the image from your phone or computer.

Screenshot 2025-09-11 at 2.32.37 PM

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Thank you, I tried everything but that :roll_eyes:

Decreases in serum α -Klotho levels in association with levels of regular alcohol drinking and binge drinking among US adults

https://academic.oup.com/alcalc/article-abstract/60/5/agaf054/8243830?redirectedFrom=fulltext

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Source Journal article:

https://ebm.bmj.com/content/early/2025/09/16/bmjebm-2025-113913

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40 drinks a week for “high” is quite high. The UK advisory limit is 14 units.

One unit equals 10ml or 8g of pure alcohol, which is around the amount of alcohol the average adult can process in an hour.

The number of units in a drink is based on the size of the drink, as well as its alcohol strength.

For example, a pint of strong lager contains 3 units of alcohol, whereas the same volume of lower-strength lager has just over 2 units.

So this report identifies high as about 3x the UK advisory limit.

I have asked the authors for an opportunity to read the paper and review in details how the calculations are performed. Where a number of assumptions are made then it is normal for the assumptions to drive the conclusions.

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Kalsotra and Diehl’s team discovered that in diseased cells, the splicing process goes awry, causing the protein the mRNA encodes to end up in the completely wrong place, affecting the shift to regeneration.

The fact that levels of nuclear acetyl-CoA affect splicing has been known for quite a few years.

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This seems potentially relevant to most of us here, because while I’ve lowered my alcohol consumption a great deal I will still enjoy a drink once in a while:

Is There a Least Bad Alcohol?

We all know about the health risks of drinking. But if you’re going to partake, it’s natural to want to minimize the damage.

Why Alcohol Is So Harmful

When you have a drink, your body turns the ethanol that’s present in the alcoholic beverage into a “really nasty substance” called acetaldehyde, which can damage your DNA, said Timothy Stockwell, an alcohol researcher at the University of Victoria in Canada.

Many tissues in the body, including those in the mouth, throat, liver, colon and breasts, are susceptible to this harm. And when that DNA gets repaired, cancerous mutations may arise.

The more ethanol in your drink, the more harmful it is, Dr. Keyes said. One way to assess this is to look at a drink’s alcohol by volume, or A.B.V., which manufacturers must list on product labels. If you’re choosing between two beers of the same size, for instance, and one is 4 percent A.B.V. and the other is 8 percent, the 4 percent beer will expose you to half as much ethanol.

And while there’s no evidence that darker liquors are more harmful to health than clear ones, there is limited research suggesting that some darker liquors can cause more severe hangovers, said Damaris Rohsenow, a professor at the Center for Alcohol and Addiction Studies at Brown University. Darker alcohols (like bourbon, rum and brandy) tend to have higher levels of congeners, substances that are created during the fermentation process and contribute to a drink’s flavor, aroma and color. More congeners typically translates to worse hangovers, Dr. Rohsenow said.

There can be exceptions to the “clear is better” rule, however, Dr. Rohsenow added. Some tequilas, which can be clear or light-colored, for instance, can be high in congeners and may lead to worse hangovers.

História completa: Is There a Least Bad Alcohol?

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Not the conventional wisdom

Adversity and being overweight in adolescence associated with accelerated ageing decades later in life. Completing secondary school education and maintaining physical activity linked to relative biological youth. Mediation analyses indicated liver, kidney and immune ageing linked life course exposures to mortality. Across 10,776 plasma protein targets, we identified 143 predictors of longevity, including MED9, strongly linked to diverse socio-behavioural exposures. These findings provide unique insights into which factors are likely to shape how we age, when in life they may be influential, and how biological effects emerge, informing healthy ageing promotion.

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Higher alcohol intake was associated with a younger brain age estimate (β = -0.27 yrs per 7 UK alcohol units per week, adj. p = 2.35×10-7; Fig. 3b; Supplementary Table 8 ). This relationship persisted after controlling for numerous confounders, including socio-economic status, educational attainment, social support, body habitus and physical activity (Extended Data Fig. 4a) . Relationships were robust over separate measures of alcohol intake taken at ages 36, 43, 53, and 63, and showed a dose-dependent pattern (Extended Data Fig. 4b) .

I think it is probably a U shaped curve, but dose depdendent deseves a: Hic!

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