#42

According to Dr. Brad, the molecular weight doesn’t seem to matter.

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#43

Looks like the molecular weight of NMR HA is significantly higher than anything that’s for sale.

This HA, sold by Stanford Chemicals is probably the most legit food grade HMW out there, but it doesn’t look easy to buy.

Analysis of HA from tissue culture media using pulse field electrophoresis showed that the HA secreted by naked mole-rat cells has a molecular weight of 6–12 MDa, while mouse and guinea pig HA ranges from 0.5–3 MDa (Figure 1b); human HA has a molecular weight of 0.5–2 MDa12. Naked mole-rat embryonic fibroblasts did not secrete HMW-HA (Figure 1b). Source

#44

And you can’t supplement it orally because it is broken down by gut bacteria and it won’t cross the skin barrier if applied topically.

3 Likes
#45

I think this is a bust for now. The NMR is a remarkable model well worth researching, but as usual, the issue is how do you transfer that to humans in a feasible and practical way; waiting for genetic manipulations is probably too long for anyone much older than about 40 atm is my guess :cry:.

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#46

Agreed. I believe preserving the extracullular matrix is our best bet for longevity right now but we need to modify our genetic code in order for our bodies to produce large quantites of UHMWHA.

4 Likes
#47

Agree, I think preserving a healthy ECM an one overlooked key to longevity. I use collagen but of course, I am not sure it is an effective intervention to get an healthy ECM…

4 Likes
#48

What brand is everyone using? Bulksupplements and Bronson seem to be the best prices if they’re legit

2 Likes
#49

I use BulkSupplements. I mix the powder in EVOO.

1 Like