#28

Really interesting dose regime!

By the way, do we know that mTOR activation increase the older we get? Is there any studies on that?

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#29

These three please. Also I’ll take the second question further: granted that he’s more excited by rapa, which of the compounds that have already been well-validated in animals does he think are most exciting for potential human translation?

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#30

Ask him why does metformin + rapamycin produce life extension beyond just rapamycin alone.

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#31

Or acarbose + rapamycin. I assume it will be similar.

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#32

Yes: lots of studies on this, in both mice and humans — liver and muscle:

mTORC1 controls fasting-induced ketogenesis and its modulation by ageing

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#33

I had some questions on a similar thread eariler. And they still remain unresolved for me personally. So I’d love if you could bring this up with Matt Kaeberlein

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#34

The enigmatic Rapamycin may be the key to unlocking the secrets of Easter Island, and the mysterious longevity cult said to have resided there, before ultimately succumbing to its mysterious fate.

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#35

Where do we find the podcast?

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#36

He hasn’t interviewed Matt yet…

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#37

You can subscribe to his youtube channel : KristerKauppi

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#38

Here is the link to the youtube channel

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#39

His opinion of this:

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#40

Matt has already posted commentary on that study, see here: Rapamycin increases Alzheimer's-associated plaques in mice, study finds - #25 by RapAdmin

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#41

Rapamycin definitely affects protein synthesis, including both basal and exercise-stimulated.

pharmacological inhibition or genetic ablation of crucial components of mTORC1 prevents overload-induced hypertrophy in rodents8-10, and the mTORC1 inhibitor rapamycin blunts the amino acid-induced increase in protein synthesis in humans.11, 12
https://onlinelibrary.wiley.com/doi/10.1002/jcsm.12505

Reference 12 is “Rapamycin administration in humans blocks the contraction-induced increase in skeletal muscle protein synthesis”

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#42

Ask him if he is on the same page as Dr. Blagosklonny when it comes to dosing.

I find this study somewhat disturbing. It seems there may be an optimal dose. In the study, the results of the lower dose were better than the higher doses
That begs the question: Is Dr. Blagosklonny’s opinion that the higher the better barring unwanted side effects?

“Our feline friends share 90% of homologous genes with us, with dogs it is 82%, 80% with cows, 69% with rats and 67% with mice”

Since we are more similar to cats than mice or rats, maybe we should rethink our dosing.

In addition, the cats in the study were just cats, not some special inbred strain.

https://www.triviumvet.com/insights/understanding-feline-hcm-prognosis-genetic-mutations-and-emerging-treatment-options-dr-joshua-stern-uc-davis

How much DNA do we share? | Average Percent DNA Shared Between Relatives | AlphaBiolabs USA.

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#43

Dr Blagosklonny is taking the same dose as Matt Kaeberlein is taking. The only difference today is that Matt cycles it.

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#44

First, if Kaeberlein is taking the same dose every two weeks and Blagosklonny is taking it weekly, it is not the same dosage any more than someone taking metformin 500mg once daily vs someone taking 500 mg twice daily is the same dosage. So no, they are not on the same page.

Blagosklonny originally touted on his Twitter feed that the highest dose without adverse side effects was the best dose.

However now in light of some other papers, this might not be the optimal dosage for humans.
I am still in search of the optimal dosage and in my case, “more”, definitely does not seem better.
That is why I am interested in Kimberlain’s research with dogs. As I posted earlier, dogs and cats share more genetic similarities to humans than rats and mice.

Since humans eventually mostly die from heart problems or cancer maybe we need to optimize the dose and not just take the maximum dose we can tolerate.

“Therefore, low-level rapamycin dosing most effectively controls tumors”

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#45

From the above table, they both are on 8 mg weekly.

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#46

What is the name of your podcast? I want to be able to find it on Spotify

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#47

Mikhail changed his dose from biweekly to weekly awhile ago so Matt Kaeberlein and Mikhail Blagosklonny is taking the same dose. Matt is just cycling with off and on periods also. Check the image I attached :pray:

1 Like