@Bicep please do not heed any advice from this wacko.
His information on isopropanol is exrtremely uninformed an inaccurate, as he seems to just willy-nilly Google shit without even bothering to READ THE SCIENCE!
For instance, this is factually incorrect:
He just googled “isopropanol LD40” and the first result of that is dermal LD50 on rabbits, which is 12.8 g/kg. That is not oral LD50, and it certainly isn’t injected LD50 which provides even more bioavailability than oral (meaning a smaller dose is equal to a larger oral dose).
If you compare that to the oral LD50 of ethanol, which is 7-12 g/kg in mice, then you can see how Dan came to the conclusion that isopropanol’s LD50 is twice that of ethanol. That is incorrect.
The opposite is actually the case - isopropanols oral LD50 in mice is ~5 g/kg. In other words, the LD50 of isopropanol is half that of ethanol.
Anyone with basic knowledge of biochemistry knows why - longer chained alcohols produce metabolites that are increasingly toxic to the body. The same goes for the opposite direction with methanol, having one carbon atom fewer than ethanol, which metabolizes to formaldehyde in your body.
Isopropanol thankfully does not metabolize into anything as horrible as formaldehyde, but it is avoided in pharmaceutical preparations for many reasons. For one, because ethanol exists! Isopropanol comes with far more side effects than ethanol, which is why it’s avoided whenever possible. The only reason Dan uses it is because he literally buys 70% rubbing alcohol from Walmart. Not joking. Here’s his post:
Furthermore, the paper he is citing that uses isopropanol is a purely explorative developmental study. In other words, just proofs-of-concept. They weren’t even tested on mice, just cell lines.
These formulation studies are done as a demonstration to say “hey it’s possible,” not as a direct-to-pharma preparation. For fuck’s sake, Dan, it says FORMULATION DEVELOPMENT in the title! Along with the words “Toxicity and Assessment!”
But you intentionally left out that last part of the title. The full title is:
Rapamycin-Loaded, CapryolTM 90 and Oleic Acid Mediated Nanoemulsions: Formulation Development, >>>Characterization and Toxicity Assessment<<<
I don’t know if you are being intentionally deceitful by omitting such an important detail, being that this is a toxicity study. I don’t know if you’re just ignorant or maliciously trying to cause harm to others in this forum by spreading misinformation. But to be honest, both cases are equally as bad.
It is often the people who refuse to seek modern, science-based medicine that end up reintroducing measles to the world.
I don’t know why you have a grudge against medicine. I have my own grievances against the system, but it is almost entirely due to the regulatory restrictions that hinder medicine, not the medicine itself.
That is exactly what you are doing. You’re throwing out all of these wildly incorrect, demonstrably false facts that have no citations, no evidence, and no reasoning other than “for the kicks.”
You have rejected every single citation, fact, and evidence that I have provided you. You seem to just believe what you want to believe, not based on proof, but on what you feel.
And you aren’t successful. You injected yourself with non-sterile tapwater from the Philippines and use Walmart rubbing alcohol in your injections, too. And surprise surprise, you got an infection from that!
Shallow and trite? So this statement of factual medical reality, is shallow and trite? And not backed by proof? Are you joking?
No, it is NOT more likely! Where are your sources? Your math?
This is demonstrably false!
An estimated 1.3 million lives in the US are lost due to unsafe injection practices, mostly related to opiates and drug abusers (which may fit your description, given your past psychedelic/ketamine injections).
Compare that to annual automobile-related mortalities in the US in 2020:
A total of 35,766 fatal car accidents for 2020. Since you won’t do the math, I’ll do it for you:
Your unsafe injection practices make you 36 times more likely to die than car accidents. Now, let’s factor in the estimated number of injection drug users within the US, which was projected to be about 3,694,50 in 2018:
Now, not all of these persons who inject drugs (PWID) do so in a dangerous and abusive manner, but let us assume the worst case scenario that all of them are drug abusers.
That means you have an annual risk of injection-related death of approximately 1 in 3 PWID. I hope you can see now why unsafe injections are such a crisis in the US and worldwide. It kills so many people that we literally have to sweep dead people off the streets in many cities of the US. This is one of the reasons why cities like LA are such hellholes nowadays.
Which is why we have to look at the data and do the math. What you’re doing, as I have calculated, isn’t something that might happen. It is extremely likely to happen, especially if you continue this behavior. This is why I am telling you to seek medical counsel. You need both mental care and drug rehabilitation.
No, it is the fact you don’t know it that demonstrates to me your lack of knowledge on what you are doing. You bragged about being able to do a simple high school derivation of calculus as if that makes you an expert, yet you can’t even recognize one of the most basic of pharmaceutical equations.
That equation was for plasma concentration, by the way. The fact you didn’t even bother to Google it speaks volumes of your willingness to actually research and validate information.
Quantum level biological chemistry? What the hell is that? Do you even know what you’re talking about? I hope you aren’t being serious.
They aren’t “know it alls,” the only one acting like a know-it-all is YOU. And like I said before, those doctors obviously know how to derive a simple calculus equation. Whereas you cannot even recognize the plasma concentration formula, a damned introductory pharma equation that you could’ve Googled. I didn’t even ask you to solve it, or derive it, just to name it. And you didn’t.
Danny boy, when they tell you not to inject yourself with tap water from the Philippines, perhaps you should listen.
Now let me turn one of your one-liners unto you.
I asked you to name a basic pharma equation, and you couldn’t come up with an answer on the spot. What does that say about what you know?
