Anyone using - Trehalose? Autophagy by rapamycin and trehalose

[Katherine_Fisher]

The neuroprotective effect of autophagy activation by rapamycin and trehalose was studied in a mouse model of Parkinson’s disease (PD) induced by neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). Both rapamycin (10 mg/kg/day, 7 days) and trehalose (2% in drinking water, 7 days) increased the expression of LC3-II (a marker of autophagy activation) in the frontal cortex and striatum of normal C57Bl/6J mice, with signs of an additive effect. Autophagy stimulation in the striatum was confirmed by a lysosomal osmotic test. In the model of MPTP-induced PD, the two drugs were applied starting from the 2nd day after subchronic daily MPTP administration (20 mg/kg/day, 4 days). …

Thus, the autophagy activation through different pathways by the combination of rapamycin and trehalose reverses both neuronal dopaminergic and behavioral deficits in vivo and seems to be a promising therapy for PD-like pathology.

Therapeutic activation of autophagy by combined treatment with rapamycin and...

[José]

FWIW

There is another thread on this site about trehalose, not with rapamycin.

I have been using trehalose in coffee{coffee is the delivey vehicle] with other added supplements in the coffee.

Review, if you have not seen/read.

Fighting Alzheimer’s with Increased Autophagy via Rapamycin + Trehalose

Good news for all the rapamycin autophagy fans here: In this study, the researchers sought to investigate if targeting mTOR-independent autophagy with trehalose in addition to the mTOR-dependent pathway with rapamycin would bring additional benefit in a mouse model of Alzheimer’s disease. … Trehalose treatment significantly upregulated autophagy in the hippocampus and frontal cortex, while the combined treatment was more efficient in inducing autophagy than monotherapies in the amygdala and dentate gyrus. Conclusion This study shows that the induction of autophagy by trehalose alone or in combination with rapamycin in general is more beneficial than rapamycin-only treatment in an animal model of AD. This points out the importance of activating the mTOR-independent pathway to add…

[desertshores]

Thank you. I do a lot of searching on Google Scholar, but frankly, it never occurred to me to pair trehalose and rapamycin.

[desertshores]

Maybe I will dump a bunch of trehalose into my grapefruit juice before I dose with rapamycin.
Seriously, I am going to do it.

[Arhu]

I decided to get some, can’t comment on any health benefits yet but I highly recommend from a culinary standpoint: trehalose adds the richness of sucrose (table sugar) to food without the sweetness

[Katherine_Fisher]

Trehalose Health benefits, dosage, safety, side-effects, and more |...

Interesting that it is poorly absorbed taken orally but yet in the mice study it was orally ingested through their drinking water.

[KarlT]

Does anyone have a source for Lactotrehalose?