Are you brainwashed at night? (by CSF - CerebroSpinal Fluid)

[tj_long]

Valdoxan increases dopamine and noradrenaline levels, kind of like amphetamine lol.

This is primarily an antidepressant and anxiety medication, even at the 25mg dose.
I was hoping this would also help with anxiety, but it remains to be seen if I can get any sleep with this at all.

[scta123]

@tj_long

dopamine and noradrenaline

I never felt anything in this regard. I noticed my sleep is better, I feel more rested and my HRV increased slightly. But I was not anxious or depressed in any way before starting taking it. i never looked at this specific way of action as it was suggested by a colleague psychiatrist whom I complained about sleep and said it is a fantastic sleep aid. That he is using it himself too.

[tj_long]

@desertshores

@scta123

or might even promote deep sleep

I have commented in other threads about the use of quetiapine for sleep
If you have no problem getting to sleep but have a problem staying asleep, you might want to give quetiapine (Seroquel) a try. Yes, it is used for mood disorders, but the amount required for sleep extension is small compared to the therapeutic doses commonly used for mood disorders.
25 - 50 mg is the amount for sleep extension. Because of its long half-life, you need to take it about two hours before bedtime. It is cheap and available from the usual suspects in India.
I can find no adverse effects for long-term use, especially at the low doses needed for sleep extension.

In conclusion, there is frequent prescribing of low-dose quetiapine, which could be due to the effect observed when treating patients with sleep disturbances. Although quetiapine can be used to treat patients with sleep issues, the results of this study suggest that the risk of metabolic consequences may outweigh the benefits. The benefits observed in the short term to aid in sleep may lead to greater complications long term and should be weighed heavily before initiating therapy. Because changes in metabolic parameters were identified, it is reasonable to suggest these outcomes are not dose-dependent. Consequently, further research needs to be conducted in order to account for the unforeseen confounding variables of this review in order to fully identify the breadth of changes in metabolic parameters with the use of low-dose quetiapine.

Evaluation of the use of low-dose quetiapine and the risk of metabolic...

[desertshores]

“it is reasonable to suggest these outcomes are not dose-dependent.”
I disagree with this. It is not usual for side effects not to be dose-dependent

Most drugs prescribed for sleep disorders are not recommended for long-term use.

If you take quetiapine, you should only use it intermittently until you find the root cause of your sleep disorder. I think quetiapine is relatively benign compared to most drugs that are prescribed for sleep. Managing the side effects of quetiapine is much the same as the side effects of rapamycin. Each person has to take the risk-reward into account.

“Approximately 10.7% of patients taking quetiapine fumarate long-term experience significant metabolic disorders, such as hyperglycemia or diabetes mellitus, as indicated by an increased blood glucose level (≥ 126 mg/dL)”

“Significant dose-dependent metabolic alterations were observed.”
“The dose-dependent effect highlighted for weight gain and lipid alterations emphasizes the importance of prescribing the minimal effective dose. However, as the effect size of a dose increase on metabolic worsening is low, the potential harm of low-dose quetiapine should not be dismissed.”

Effect of Quetiapine, from Low to High Dose, on Weight and Metabolic Traits:...