Here’s the data:
My eGFR went from 111 to 109.5
My Creatinine went from 61 umol/L to 64.8 umol/L
Was there anything else that is kidney-specific that you’re interested in?
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Cystatin-C is a good kidney marker
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@Joseph_Lavelle Thanks, but unfortunately my bloodwork didn’t include that variable.
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I find that these kinds of estimates vary considerably across studies and study conditions @DeStrider. Unless one wants to request the dataset and perform an analysis, it is sometimes tough to calculate error terms and standard deviations. Your personal experience of a 45% reduction is not too far off from the 40% upper end suggested by the other summary and is at the high end of most findings. I should expect these differences to be within 1-SD. Also missing from most of these studies is casewise analysis. In one example, I found that the claimed reduction in hsCRP was valid only with high pre-treatment levels. Someone whose baseline hsCRP was, say, 0.35, experienced no significant further reduction. Also, just guessing, the amount of reduction in CRP is likely to vary with the source of the inflammation.
For another view I had in mind when posting, look at this 2021 meta analysis where the following was found (all 95% CI & look at the range on hsCRP):
Seven eligible trials of bempedoic acid (3892 patients) were included. The bempedoic acid therapy was associated with a significant reduction in LDL-C levels [-20.3% (CI 95% -23.5 to -17.1)]; I2=43%]. Similarly, a significant percentage reduction in the apolipoprotein B levels [-14.3% (CI 95% -16.4 to -12.1)]; p<0.05; I2=46%], non-HDL-C levels [-15.5% (CI 95% -18.1 to -13.0)]; p<0.05; I2=53%] and hsCRP [-23.4% (CI 95% -32.6 to -14.2)]; p<0.05; I2=69%] was demonstrated with the bempedoic acid use. The sensitivity analysis showed that the results were robust.
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Bempedoic Acid and Ezetemibe work wonders for me and my father. Our blood work testifies to that and we’ll continue to use both drugs.
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LaraPo
#47
You have excellent results! Doesn’t look like bempedoic acid caused any harm. I may try it with caution.
Yes and tremendous eGFR. I would love to have that value.
Ulf
#49
Do you remember where you saw that on only ALA being affected? The study linked by Joseph only tested ALA not EPA or DHA. And it indicates a huge drop in ALA.
@Joseph_Lavelle had his omega levels tested on Ezetemibe and nothing was impacted I believe. N-1
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True. My omega index was 12% after 2 years on ezetimibe (10mg/day). I’ve been eating salmon and tuna most days for 15 years, and taking a low dose fish oil 2x/day for 10 years.
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Effects of mitochondrial dysfunction on cellular function: Role in atherosclerosis - ScienceDirect
The article notes “the key role of mitochondrial dysfunction in the pathogenesis of atherosclerosis” and states that “therapies targeting mitochondrial dysfunction are promising strategies to treat atherosclerosis.”
The risk factors for mitochondrial dysfunction are given as hypertension, diabetes, obesity, and aging. All but the last can be addressed if not controlled.
Am I correct in thinking that rapa ameliorates mitochondrial dysfunction?
I believe exercise also ameliorates mitochondrial dysfunction as well as intermittent fasting, as do various vitamins and supplements (arginine, carnitine, citrulline, coq10, creatine, NAC, niacin, vitamin C and K, among others).
Any additional thoughts about improving mitochondrial health?
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While I disagree with Peter Attia’s judgments that diet and nutritional supplements play a relatively small role in optimizing healthspan, I think his view that exercise accounts by far for the greatest variance, possibly more variance even than emerging “longevity drugs,” is well supported by evidence. Attia says he chides patients who want to jump on the supplement bandwagon even though they exercise only modestly and have average VO2max.
A large number of studies over 20-30 years have demonstrated that exercise promotes a robust increase in mitochondrial content, as well as improved oxidative phosphorylation and respiratory capacity per mitochondrion. Aerobic exercise can increase mitochondrial density and function, and can also reduce mitochondrial fission, improve autophagy, and enhance fusion. Exercise can also improve mitochondrial ETC activity in older human skeletal muscle.
First things first, maximize VO2max and perhaps a few other fitness metrics. Note, however, that there may be little benefit going beyond having a relatively high VO2max as Attia’s chart suggests.
Additionally, while there is little evidence to support this idea, it seems likely that supplements will have greater impact on a body that is optimally fit for a given age and circumstances.
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Neo
#54
Fasting, Zone 2 (and Zone 1) and UA/Mitopure are other ways to optimize mitochondrial health.
All discussed in rich ways elsewhere on the forum.
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