I missed that. Very interesting, and very easy and cheap to do if the import/export channels are open… but if not 
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Thank you. Yes, that’s a very interesting hypothesis. I don’t know that anyone has proven this out, or if anyone has tried it with positive results? Matt K. also suggests a rapa toothpaste for periodontal and other general oral benefits.
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curt504
#46
LOL, exactly. He’s just polishing himself for a larger commercial foot print. Near zero new info (IMHO) just polish and promo.
Read his book, tossed it. Too drug-y (statins) too decade old… Nothing new (for me). Today this article; Just buz and promo IMHO nothing new for us. Sure lots new for SAD’ers, sick Americans but thats not us here.
Good luck, curt
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jakexb
#47
A quote from his recent longevity 101 podcast really struck me how big the shift has been from “life extension” to “let’s just try to slow the damage a little”
“I was thinking about this today in the gym actually, I was like, wow, it is really so obvious to me with each passing day that I am completely past my prime physically and cognitively. And I will never again be as physically strong, fit, flexible, free of pain.
Like pick your metrics that all make up physical health span. I will never again reach the pinnacles that I had reached in my late teens and 20s. And similarly, cognitively, I’m basically a moron compared to the person I used to be, in terms of processing speed, problem solving, just raw intellectual horsepower.
Those things are going to decline even further.”
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Oddly, in my 85th year, I am more pain-free than I was in my 20s and 30s. In my late 20s, I was being treated regularly for pack pain, and I remember often having headaches. In many areas, I am still as physically strong in terms of raw muscle power because I have been going to the gym, running, and playing tennis most of my life. What I have lost is speed, endurance, and reaction time.
I don’t even remember the last time I had a cold or the flu, at least many decades ago.
What do I attribute this to?
Exercise
Poly pharmacy
Rapamycin (Shortly after starting rapamycin in Dec. 2021, at a relatively high weekly dose, I have been pain-free, including headaches and the typical pain that accompanies old age, arthritis, neuropathic pain, and fibromyalgia.)
Genes
Immunization shots. (Because of the military and my employment in foreign countries, I have received too many shots to remember. Starting from childhood to my most recent flu shot. Among them are mumps, measles, tetanus, diphtheria, pertussis, and yellow fever, etc. My most recent vaccines in the last few years are influenza, COVID-19, shingles, RSV, and pneumococcal. The only one that I had a severe reaction to was the Pfizer COVID-19 vaccine.)
Cognitively, the most significant decline has been in processing speed, the ability to do math problems in my head, and the ability to memorize lists, etc., for any substantial amount of time.
Subjectively, my most significant decline is in energy and endurance, though I still seem okay at the gym.
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sol
#49
My story’s a little different, but has in common with @desertshores that my experience of general health and lack of pain is notably better now in my 60s than it was in my 20s.
It’s not a simple equation – some things are better, some are not. For me, it’s likely that I was particularly impaired in early adulthood, with deleterious biochemical inputs (pollution, etc) that cost me health. But also, in those days, estrogen wasn’t bioavailable as it is now, and that had a strong effect on me, too, positive and negative.
Yes, my energy was better then as was my ability to put on muscle mass. (Then there’s elastin which I sure miss having plenty of.) But I was injured a lot, sick a lot, and didn’t have mood stabilization. Significantly better now.
Among the many things to which I attribute my impressive health improvements are 15 years of methylation cycle supplementation (like a reboot), ceasing non-bioidentical estrogen in my 20s, recent bioavail HRT, and two years of rapamycin.
There might be other factors. I eat well, exercise regularly, and prioritize human contact. There are a lot of inputs.
My point: yes, it is possible to feel better in many ways than you did in your twenties, depending on how things were for you in your twenties. I’ve been working this stuff for 40 years, because I had to. My health – and at some points my life – depended on my figuring things out. I’m still figuring things out.
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What does that mean? If you’re talking about living longer, statins are pretty much the only drug that is actually show to help you do that.
And I don’t think it was meant to be new. It’s a sort of common sense guide for the general public on how to think about longevity and some of the steps they can take. Getting your medical checks, dealing with cholesterol etc is longevity 101. If you’re already into taking Rapamycin, one would assume you’ve already taken care of the basics like smoking, diet, blood pressure, cholesterol etc.
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KarlT
#52
Recent video with Dr Attia and Rhonda Patrick about protein, but they briefly discuss Rapamycin and bring in viewpoints of other scientists who feel there just isn’t adequate evidence that Rapa does anything in humans.
I agree with Rhonda when she essentially says “worm and fly studies are meaningless”.
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That’s why we have mouse and marmoset studies. Human studies have shown benefits as well. Since you’ll never have true human longevity data for any drug, you place your bets with the knowledge you have.
Maybe people will look back in 50 years and say ‘Wow. Those people who took Rapamycin are breaking all those longevity records. Maybe there’s something to this. It could be better than booze and yoghurt!’
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Yes - I think most of us agree with that. Interesting from a scientific standpoint, but little else. Of course, mouse, rat, dog and marmoset data is something else entirely.
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Engadin
#55
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KarlT
#56
I think there are questions about the validity of using studies in mice to determine longevity in humans.
I’ve been looking at some articles on predicted vs actual lifespan of animals. Mice live a bit shorter than expected, and humans live longer than expected. Thus it may be easier to extend lifespan in mice.
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jnorm
#57
Some of you guys come up with the weirdest conspiracy theories where you question everyone’s motives. Attia is one of the realest ones there is. He gives his educated opinions and has never once made anything up as a result of some ulterior motive. Not everyone is an asshole like some of you guys think.
Promoting Athletic Greens, David bars, and Maui Nui processed meat sticks isn’t ulterior motive? Even if you cut him some slack on that, you should stop taking him seriously the moment you see his protein recommendations.
Also, just from the fact that the guy’s in his 50s and suddenly decides to cover his arm in tattoos, or thinks recapping his movie nights with Kevin Spacey in his IG captions makes him look cool, you should realize that he’s not all there mentally.
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KarlT
#58
Are we a little judgmental? Btw, I think David bars are awesome.
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jnorm
#59
Questionable judgement is questionable judgement. And as a public figure who’s influencing people’s health decisions, his judgement should be evaluated accordingly.
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I divide the Peter Attia phenomenon into early Attia and late Attia. I was listening to his podcast pretty much from the beginning, and he had excellent guests on, really went in-depth on the topics, and even if his questions were somewhat meandering, the overall quality was first rank. He didn’t push stuff too aggressively and always fully disclosed his involvement. Then came late Attia. A real heal turn. He started getting super sloppy on some subjects despite claims to follow the scientific method - he completely crapped out on nutrition, didn’t understand epidemiology and epi studies methodologies (exposed by the Viva Longevity - formerly Plant Chompers guy), terrible protein advice clearly influenced by his economic interests, promoting junk products, shady disclosure practices (Oura ring fiasco), the subjects he started covering on his podcasts became almost random (archery, car racing, deer hunting), his podcast became a wasteland (I almost never listen to it these days), the quality of his guests dropped, he became involved with guys like Huberman, and his book was mostly a waste (plus filled with errors, seemingly not edited - no, Mendel was not German, he was Austrian Czech Silesian etc., minor point, but indicative of sloppy approach). At this point, I’m really not that interested in what Attia says, don’t care about his courses and other money making ventures. Late Attia is a borderline scammer rapidly transitioning to full on scammer. RIP, Peter Attia’s reputation.
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LukeMV
#61
Maybe he just ::gasp:: believed in them at one point and no longer does or maybe I’m just naive for thinking there are public people out there who don’t all have nefarious intentions
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KarlT
#62
I guess then I would question yours.
And thanks for reminding me of why I don’t read this forum much anymore.
