#515

And now this… Bryan is building a religion. Not terribly surprised he wants to be a cult leader. Lol

Link: Anti-Ageing Millionaire Bryan Johnson Says He's "Building A Religion" To Save Human Race

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#516

And now the irony… as the “Don’t Die” religion’s leader - that eschews rapamycin.

As always the case… the cult leader send their entourage to an early end. Lol.

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#517

Is the statin at the maximum of what you can tolerate? Increasing to every day, and using a higher dose would be an easy and obvious (and very cheap) to way to lower ApoB, so I assume there’s a reason you haven’t done that?

Yep, but Brian seems to be quite “scared” of really going for LDL lowering. He quit statins, I seem to remember, even though they’re one of the most accepted drugs for increasing your healthy lifespan and delaying the number one killer. Instead he’s happier to embrace alternative cardioprotection like EVOO where there is some evidence, but it’s not as strong.

Obviously his current level isn’t really enough to cause an early death from ASCVD, but if he wants to live forever, then it would eventually catch up with him.

(Assuming no AGI, ASCVD reversal etc)

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#518

Gotta get the entourage to drink the Kool-aid!

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#519

Or… eat his damn nutty pudding. Hahaha!

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#520

Have we discussed how low he now has gotten his rate of aging according to the Dunedin PACE clock?

(That’s the third gen clock that the scientific community seems to think is the best one so far developed)

Less than 0.5…

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Thread :thread:: https://x.com/bryan_johnson/status/1897337303187775563?

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#521

Going with a higher statin every day causes me muscle spasms. EOD does not. I am statin intolerant unfortunately.

#522

Gotcha. Then yeah I would think that PCSK9i is the next step. Personally I find that one injection per month (Repatha 140mg) is very effective for me, but from what I’m seeing peoples’ responses vary quite dramatically.

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#523

I stopped doing the Trudiagnostic tests, mainly because my epigenetic age (s) were going down, but the rate of aging was going up (initially 0.78). I am not myself clear what dunedinPACE measures and I have reliable metrics for function which in the end is what the priority is.

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#524

According to the leaderboard, that’s Bryan’s best test result on Dunedin PACE if I understand it correctly, his best 3 test average result is 0.540 past 2yrs.

What’s the definition of rate of aging in the literature?
This seems that it has not worked out with definitions, neither have I’ve seen anyone make a persuasive case, or am I wrong?

It makes sense to measure things in the body like (bio)markers, adjust, and correct in the future as well.

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#525

I saw that the other day when I was checking to see where my wife and I are at this time. She is still top 50 (Joan Matheson) but hanging on at #50 I’m out of the top 200 now at 206. We will be doing our 6th test in April.

The number or participants is now over 5,600.

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#526

@AnUser the clocks def can continue to be improved

But they do seem to provide some very valuable signals

My main question is

  • has BJs measure fallen this much because his general health/aging has improved

  • or has he found ways to game the specific test

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#527

I don’t know (fyi no affiliation).
It’s very specific data anyway, something I’ve only seen Lustgarten iirc release.

#528

Johnson, who is spending millions of dollars in an effort to live forever, underwent follistatin gene therapy in early 2024 and said he was impressed with the results.

He had no adverse reaction to the procedure and, six months later, tests revealed his speed of aging had dropped to 0.64, meaning he would celebrate his birthday every 19 months, aging slower than people who celebrate the typical every 12 months.

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#529

Ah right, speed of aging decreased after that.

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#530

The problem I have with all these aging tests, even the pace of aging, is that they associate aging with a biomarker that is common for people around that age. However, making that marker ‘younger’ may not extend lifespan.

For instance, if people at the age of 60 have on average 5 age spots on their face and people at the age of 30 have none, and I, as a 60 year old, go in and have all my spots removed by a plastic surgeon, I do not suddenly become 30 years old.

However if you do an intervention for the marker that these epigenetic tests focus on, you are gaming the system in the same way. We need to know which marker is truly related to lifespan, and I don’t think we do.

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#531

I think DunedinPace does predict time left to disease onset and to death very well…

… so seems like more relevant than that

DunedinPACE reveals wide range of population aging rates and can predict future disease and mortality

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#532

Removing age spots is a cosmetic procedure and like any cosmetic intervention it has nothing to do with biological age. It’s just masking a problem. You are right that we need to go to the core of it. Glad BJ can afford it.

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#533

Define “extend lifespan” are we talking about extending it beyond the human genetic limit of 120 years or are we talking about extending it beyond the “average” statistical lifespan?

To me the word lifespan is pretty much meaningless.

I prefer health span as we currently have no way to extend lifespan beyond 120 so I prefer to focus on maintaining health over the time I have left to live. That time is based on statistics.

In Canada the statistical lifespan is 83.1

In the US the statistical lifespan is 79.3

As far as the epigenetic markers not being helpful in managing health span, I could not agree more. They don’t mean a lot compared to other tests that do matter and are actionable.

But epigenetic testing does provide insight into other aspects of health, some of which are actionable.

The Dunedin PACE test doesn’t provide actionable input but statistically it appears to indicate overall mortality risk. Combine that with “regular” tests and you have a bit better picture of what may be influencing your health span :slight_smile:

I do know that what I’ve been doing over the past 5 years has improved all my typical blood tests and at the same time improved my Dunedin PACE results.

The best part is I can share my Dunedin PACE without revealing my personal health history. Although as a Canadian sharing personal health history is not as big a deal as it is for Americans. Universal health care doesn’t care about my history :slight_smile:

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#534

I would agree that the correct target is healthspan. I am quite happy with compressed morbidity as a concept. Realistically, however, an extended healthspan is likely to have an extended lifespan.

However, I have stopped spending money on methylation tests.

They don’t to me provide any actionable information and I think there is a danger of targeting something like DunedinPACE when it is not clear what it actually means.

Bryan Johnson targets DunedinPACE. However, he does not take Rapamycin.

Much that we can discuss dosing strategies with Rapamycin it does appear to be a useful tool to improve mitochondrial efficiency.

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