#270

I watched the interview, which I consider one of his best presentations of his agenda. He stated that he trusts nobody but the numbers and is about to launch another stage of his BP program by delivering food, supplements to our (consumers’) doors for us to just blindly consume it 3 times a day in hope to achieve what he has already achieved. It’s a kind of a cookie-cutter way to treat everybody with one size fits all approach. I don’t buy it. We are all different and what works for Bryan may not work for me. His bio parameters are measured, not mine, and mine are most likely different from his and therefore his designer formula may not benefit my needs. I had a feeling that he looks at us as a crowd with crowd mentality (reminds me Hitler’s approach) and he envisions himself as our leader who would guide us for survival and immortality. It’s a little laughable taking into consideration what is happening in the world right now. Just my 2 cents.

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#271

Do you really think Oliver has any other clients? I suspect Bryan is pretty high maintenance and is likely his only client right now… Of course his plan is to expand.

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#272

Not sure that is a fair characterization. It seems that he is really trying to arrange so that several thousands of people do a lot of testing (blood work, ideally body composition/dexa, etc) and in that sense is putting the blueprint “light” components/product to the test and inviting scrutiny and objective data

See below and also @Paul_2.0 s post

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#273

Not sure. I know he was building this whole systematic set of framework with all the body sub-system measurement and optimization protocols for a while - and before BJ I think.

I’d imagine that there are other wealthy individuals that have reached out to him and want to do a version of the data rich, optimal protocol (and that they’d generally want to keep it private). But I’m just guessing.

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#274

I don’t want to become an apologist for Bryan. I’d agree there’s a bit of a messianic tinge to some of his ideas, which I find a turn off.
I signed up for the blueprint protocol and was accepted, so I’ve been getting regular emails. I’m still not sure if I’m going to do it. Bryan’s team are trying to build some datasets from Blueprint. They’re tracking blood and body comp and sleep data. To my knowledge nobody has done this yet, and if there’s going to be any movement towards preventative interventions this type of thing has to start somewhere. If they can build a dataset of 2500 people and show that their protocol works great. The idea of collecting data on this site has been muted several times and it’s incredibly challenging. We don’t have to agree with Bryan to see the value in the exercise. One of the things I like about this forum, is there are a lot of people who don’t really follow the herd. Let’s face it, most people aren’t taking experimental drugs in the hope that it may extend their lifespan. The majority of people most likely never even think about it.
What I see here is a genuine attempt to quantify health span and try to build a framework, albeit a really basic one, that gives people a direction to take control of their health. One hundred percent agree that Bryan’s N of 1 is specifically tailored to Bryan, but there’s still value in an attempt.

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#275

I am only halfway through this video and I find Bryan one of the smartest people I have ever seen on YouTube. I believe in ~90% of his philosophy on religion and his worldview.
Basically, as a technologist (electronic design engineer) I agree that the technology of life extension is on a trajectory we don’t even comprehend. Ai is probably (I hope) going to be able to help us extend lifespan beyond what we presently believe.

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#276

Yes, I agree with the majority of the things he has to say. I don’t have any kind of scientific or engineering background, but I read extensively and I’m cautiously optimistic that we’re at an inflection point in the evolution of not just humanity, but consciousness.

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#277

Yes, he’s encouraging ppl to test but will he adjust the ingredients according to each person’s biomarkers cocktail? Or will everybody be taking the same stuff? Doubt he will. It’ll be one size fits all. This is what I have difficult time accepting.

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#278

You’re one hundred percent correct that this won’t be tailored specifically to individuals, but this is no different than any other drug trial. Drugs are approved on their median effect. It’s most likely impossible to control the parameters of a study like this, but I’m not sure they need to. They just need to see if things improve for the majority of the participants.
I doubt it would be possible to build that kind of precision into any trial unless, like Bryan that’s all you focus on or people live in a laboratory.
Imperfect data is better than none at all I suppose.

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#279

The difference is that he’s selling not just one drug, but 100 supplements, food, drinks, etc. He wants his followers to eat 3 times a day only the food that he sends them. Isn’t it too much?

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#280

Then ppl will get the wrong idea that if they eat and do what BJ tells them to, regardless of their own unique health situations, they will live forever.

#281

But, that’s the blueprint protocol. He isn’t saying that there’s one pill. I believe they’re trying to pull as many interventions together in one place. Not disagreeing with you, it is a lot, but I’m not sure that means it should be disregarded. BTW, I don’t think blueprint is really going to move the needle. The fact that there’s more complexity to it is a strength though.

#282

I don’t get the message from Bryan that blueprint is going to make you live forever. People are free to make up their own minds. If someone thinks that eating Lentils and broccoli every day if going to confer eternal life, good luck to them.
I’ve said before my concern is all of this will flame out when people realize that no amount of kale is going to deliver on longevity escape velocity. But after listening to Bryan, I’m not sure that’s the point here. I don’t think the point is about selling supplements, it’s about working towards a way of thinking that focuses people on taking care of their health.

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#283

Complexity could be a strength. Bj has his own personal doctor who works with his team only for him 24/7. Blue print was designed for BJ, tailored for him and his biomarkers. He’s 45 yo male. Blue Print took that into consideration too. It was not designed for all genders, ages, physical, emotional, mental deviations of the rest of humanity. It’s a great design FOR BJ! This is the point I want to make. But don’t get me wrong, I like BJ and his pioneering ideas.

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#284

He wants to be immortal and he sends this message to all his followers. Could it be the beginning of a new religion?

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#285

I sincerely hope not. Last thing we need is another cult, they tend to end badly

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#286

It seems he does have other clients.

Ferrucci cautions that testing multiple interventions on oneself, beyond being potentially dangerous, is not scientifically valuable because it’s impossible to isolate what, if anything, is working to reverse the aging process. “An experiment with an n of one tells you nothing,” says Ferrucci. If an extremely wealthy person really wants to advance knowledge, he says, they should “give their money to researchers.” Zolman says it’s “absolute bullshit” to assume that an individual experimenting on himself can’t be scientifically useful, citing Barry Marshall’s self-experimentation with Helicobacter pylori, which led to a Nobel Prize in physiology in 2005. Plus, Zolman says he’s aggregating data from his 60 clients with the ultimate objective to get people like Johnson to fund larger studies about the biology of aging.

From this:

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#287

I don’t believe this and I don’t care if what I do is of scientific value to any one else, I will be the judge of that.

Many of the people on this forum do fairly extensive testing, John_Hemming comes to mind.
Even though I don’t do anywhere near the number of tests he takes, I do have many tests a year to see what any particular supplement has on my biomarkers.

At 82 I cannot wait for the outcomes of various intervention trials that will take longer than I am expected to live. So, I plan on being on the cutting edge of new developments that I can afford and will not be waiting for extensive confirmation or RCTs.

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#288

“pulling the strings behind Johnson’s reportedly $2 million longevity craze is a team of 30-plus doctors and health experts, led by 29-year-old Oliver Zolman—a millennial doctor obsessed with turning back the clock.”

"Zolman goes to the next phase, the therapies. “You try and get all the markers below chronological age,” Zolman continued. “If your markers are older and more clinically relevant, then you want to target those organs first.”

This is exactly the paradigm I was following long before I ever heard of Bryan Johnson or Oliver Zolman.

I am sure that this has been the practice of many members in the forum.

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#289

I believe that’s exactly right. I’ve been slowly working on the areas of myself that need to the most attention. I have a limited budget, but I’m willing to spend within reason, if I think I can do something to materially improve my health. There’s still more to do. Isn’t that what we’re all doing?

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