Neo
#577
Does that impact the half life or the creation of new elastin?
It affects the creation of new elastin.
Neo
#579
@John_Hemming Interesting, I thought our bodies basically do not create new elastic past puberty. How meaningful is the ability to create new elastin as we age even with optimal splicing?
1 Like
Its like maintaining any protein. There are systems of homeostasis. The problem with splicing is that it is driven by the acetylation of splicing factors and the histone hence insufficient acetyl-CoA will cause splicing problems.
I do an easy test on this each week when I do my blood test by varying the acetyl-CoA levels in my cells systemically that results in different speeds of repair of the venepuncture.
You can see some photos on this web page (which is part of a poster I presented at a conference in the UK last year).
https://citrate.science/2024poster/poster.html
I am not aware of anyone else experimenting in the same way as I am with directly trying to control acetyl-CoA levels. (although other people are working with me).
One thing I have learnt from the experimentation is that the timing of energy levels matters. There is at some point a signal to repair the insult. If the acetyl-CoA level are high enough at this point then it repairs rapidly. Increasing them later probably does make things better, but the repair is still a lot slower.
You can see that with the fact that I have two venepuncture insults in the same elbow and the later one repairs more rapidly than the earlier one simply because of increased acetyl-CoA levels at the right time.
Jjazz
#581
Where are you guys getting the 0.69 number? In the Nature paper, Omega 3 reduced Dunedin Pace by 0.17, not 0.31.
3 Likes
JuanDaw
#582
Nick’s vid at 7:20. Seems Nick was referring to the upper limit.
DunedinPACE d = −0.17 (−0.04 to −0.31)
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I’m looking at this and just thinking that they’re kinda all over the place. And none of them address whether Omega 3 is actually slowing the pace of aging, or it’s just gaming the system by directly affecting something measured by the tests. I still don’t put a huge amount of value in these clocks, but I think they’ll get better over time.
That said, since both Omega 3 and Vitamin D are safe, cheap and common, they are no-brainers to supplement IMO.
I also note that in the paper, 30% of the participants had Vitamin D levels of <30ng/ml, which is deficient.
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Neo
#584
Gents, I’m confused now
@Steve_Combi says roughly: Elastin is fundamentally different and we do not really grow any new
John says roughly: it’s like any other protein, if we fix the splicing we will grow new, healthy elastin
What are your thoughts on the other persons perceptive?
I think we need to fix the splicing. That is essentially fixing aging. However, I think I know what aging is. It relates to the efficiency of mitochondria which drives cytosolic acetyl-CoA levels which drives splicing.
Hence if you fix aging there is no issue with elastin.
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@Neo I’d suggest that reading all the papers I’ve provided as a reference would be the first place to start and then compare that to the papers that have been provided that support the other side of this discussion.
juliogf
#588
4 Likes
AnUser
#589
Has Bryan claimed that the food he sells with this service is the food he eats? Likewise, has he claimed that it’s lab tested?
The answer to both of these questions is no, so the video is arguing against a straw man.
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juliogf
#590
Oh, I didn’t argued about one video, I just sent one link to reference.
Please check the 30 of the series, and judge by yourself.
I have my personal beliefs, and the videos make my beliefs stronger.
If you want to know here they are:
1-He affirm that he is transparent, on the tests being made. That he does to help make a protocol to help all humanity. I don’t agree, as there is low data, cherry picked. (Why exams results are not all posted? the good? the bad… doesn’t matter, if the objective is to help humanity, opening results, will bring people helping evolve "the protocol.
2-He affirms a lot about his staff, his doctors. I don’t know why not show then explaining, so we can understand the technical info from the staff.
Helping humanity, there is no need to close the knowledge.
My conclusion, it is not about help people live more.
It is a history, story telling, made to sell supplements!
As a business person, I congratulate who invented this history, because it was very successful!
As a longevity enthusiast, I maintain watching with a yellow light.
7 Likes
Hence if you fix aging there is no issue with elastin.
Carts and horses on that one.
Actually no. Aging causes two main types of age related disease. One is that stem cells fail to differentiate and become stuck half way through. You can see that with osteoblasts and osteoporosis. The other is that the wrong development splices are produced. You can see that with the failure to replace elastin.
Now. OK this is my hypothesis as to what causes aging and that the main pathway goes through levels of cytosolic acetyl-CoA.
I am quite happy to defend that hypothesis if you wish.
Now if I am wrong about this, then I am wrong about elastin.
1 Like
AnUser
#593
Send any other ones you think are important then.
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AnUser
#594
Bryan Johnson’s ideas are not new… but he is popularizing them.
As the press release succinctly puts it, Federov’s “Russian Cosmism was a movement that called for material immortality and resurrection, as well as travel to outer space. It developed out of the spirituality of nineteenth-century Russia and a strong fascination with science and technology.” The hitch in Federov’s philosophy is that he was an atheist—or at least he had a big falling-out over religion with onetime admirer Leo Tolstoy. Federov’s brand of immortality would be accomplished without God or a spiritual afterlife. Think “put a human being on Mars by 2030” squared, plus the necessity of colonizing other planets, since the billions of corporeal humans brought back to life would make the New York subway at rush hour seem like midnight in the Sahara Desert.
Federov realized the magnitude (to put it mildly) of Cosmism’s central task, and called upon everybody in every profession and enterprise to make material immortality humanity’s “common project.” After all, he reasoned, we struggle to overcome hunger and disease, so why don’t we all get together to struggle equally if not more so to overcome the ultimate bummer, death itself? Such pie-in-the-sky (or borscht-in-the-cosmos) appealed to the likes of Aleksandr Rodchenko (whose “Construction on White [Robots],” 1920, is one of the better works in the paintings gallery), Maria Ender (the fully abstract “Transcription of Sound,” 1921), and Gustavs Klucis (whose logo design from 1922 reflects Cosmism’s onward-and-upward imperative).
‘Art Without Death: Russian Cosmism’ Review: Immortality and the Cosmos – WSJ, 2017
https://archive.is/bEuBd
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AnUser
#595
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Beth
#596
IMHO that was a pretty effective response. What did you think?
Based on this, it seems so obvious she made the entire thing up that I wonder why he didn’t do it sooner? Now I’m scratching my head wondering what I’m missing?
I’ve never understood the part about an ex (non spouse) demanding money that was promised. I mean, if all the guys who promised me things when I was dating them paid up, I’d be living next door to Oprah 
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