As I see it he is the sort of person that comes into the public domain and then over time leaves. I am not aware of any particularly new idea he or his team has come up with or any scientific discovery.
On the other hand he has not been doing me personally any harm or as far as I can tell anyone else on this forum.
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LukeMV
#681
I think you may have misunderstood . I’m saying you might be right after all since just about 100% of people on GLP’s see an increased rating heart rate despite profound health benefits.
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If BJ’s negative assessment of rapamycin leads to fewer people taking the drug without adequate research and preparation, all the better. We don’t want people getting hurt. Plus, BJ seems pretty influential, so not having a massive run on rapamycin, means there’s less pressure on the supply for those of us using it 
.
But more seriously, we don’t need a bunch of unprepared followers sustaining health damage by jumping on a trendy drug. Rapamycin for the nerds, not the fashion followers, lol.
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A fair point. In a similar vein Trump’s tariffs on Rapamycin will benefit rapamycin users outside the USA.
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Obviously we agree on this. I did misunderstand your reply. My conclusion is that biomarkers need to be considered in the circumstances. This is harder but provides more reliable actionable information.
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Pfizer will build the biggest rapamycin factories in the US! Bigly!
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In a broader sense, however, the reduction in oil prices is likely to cause quite a problem for the USA. However, it is also likely to drive an increase in economic activity in the rest of the world. It depends how long it lasts. (it cannot last for ever)
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jnorm
#687
Hence although I think it is arguable that a lower resting heart rate is an indicator of better heatlh, it is not necessarily the lower heart rate that causes better health downstream.
There are exceptions with things like blood pressure where a high blood pressure can be the cause of further damage.
The evidence for RHR causally impacting all-cause mortality isn’t strong anyways. The largest and most recent MR study found no association between RHR and ACM, suggesting the association found in a previous study was due to weak instrument bias. Elevated RHR did increase risk of dilated cardiomyopathy, but decreased risk of AFib and stroke. Source: Genetic insights into resting heart rate and its role in cardiovascular disease
It’s not like LDL-C and atherosclerosis where we have loads of evidence (RCTs+MR+mechanistic evidence).
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"The LAM Foundation was made aware just yesterday by Pfizer that they will no longer sell or have availability of their brand drug, RAPAMUNE® in the United States, effective December 31, 2023. Please be assured that there are many manufacturers currently producing sirolimus, the generic form of RAPAMUNE®, to serve LAM patients.
Pfizer informed us they have decided that the availability of generics is sufficient to meet the demand for sirolimus in the U.S.
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Bryan Johnson, Is he the New Poster Child for Rapamycin Use?
Ummm… now that Bryan stopped using rapamycin… and even more so has gone on a campaign to identify it as poison and detrimental to health and aging a person faster… I guess that topic didn’t age well… can I reclaim the title of Poster Child for Rapamycin?? 
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Since you put so much weight on mitochondria failing in aging, I thought your reasoning for taking citrate is to make the mitochondria more efficient (which would translate into increased ATP production). Earlier in your thread you said this:
“However, I think I know what aging is. It relates to the efficiency of mitochondria which drives cytosolic acetyl-CoA levels which drives splicing.”
What exactly are you trying to accomplish with the citrate ingestion?
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In the cytosol citrate is converted to acetyl-CoA
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AnUser
#694
https://x.com/bryan_johnson/status/1938267110314283294#m
Is this what people in the 25th century will think about?
Or what will be the chimp looking at helicopter moment for what’s “hot”, “being jacked”, and “have a great sex life” today, but for that far in the future?
I can’t be the only one that thinks the future might be greater than this, and we’re the chimp.
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Unfortunately, we’re still the chimp. I would love to live in the future, but that’s not to be for now.
Come on cryostasis technology!
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To appeal to people right now you need to appeal to these types of desires.
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AnUser
#697
I’m not sure that’s a good idea but I don’t know anything about this.
When is the endpoint where you don’t have to appeal to people in this way? The risk is you become more and more generic to appeal to the masses, lose your moat.
If all I knew about Bryan is that he would talk about sexual health and getting jacked, that would be too generic for me. Isn’t advertising supposed to lure you in?
It was interesting when Bryan went viral because he is the Silicon Valley stereotype of living forever, what people thought people did behind closed doors, and he put it out in the open, IMO.
That might still be his moat. But I don’t know. I was also referencing my own experience, I don’t think what we want today is the best it will get, like sexual health and appearance is important for positive valence from sex and relationships, but it’s not high up on the log pleasure scale although we want it a lot, so technically future is probably nothing we can really imagine, so like the chimp looking (imagining) at the helicopter. Or people wanting faster horses rather than cars, etc.
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We are people already interested in health and longevity, so quite frankly he doesn’t need to appeal to us. We’re not going to say “well this is crass, I’m going to eat some McDonalds”.
People want to look young, people want to be hot, people want to be jacked, people like sex. There is nothing wrong with any of that, these are all youthful features that are lost with age. Instead of people doing steroids and getting plastic surgery we can make them interested in getting results in a better newer way.
Different subsects of people will find different aspects of anti-aging appealing.
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Agetron
#699
People want to look young, people want to be hot, people want to be jacked, people like sex. There is nothing wrong with any of that…
Exactly… and to some degree this is very achievable.
I would never have imagine how much physical change and health I would achieve since my 60’s. To be 67.5 years and people think I am 50… and feel like I am 50 again… tbh I start taking it for granted.
Kudos to @RapAdmin for creating this site. So many health changing ideas, information and resources… that would have taken me a lifetime on my own.
If I have assisted anyone back… makes me smile at my humble N=1 experiments.
To have heavy hitters like Matt Kaeberlein and Yelena Budoskaya interested in my journey and message me is fantastic. Their true research interest in longevity has them looking for the outliers and seeing what we do… and what benefits are gained. Longevity is a fun project.
Here for a while … looking… feeling great.
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