#269

Dihydroberberine requires a smaller dose for the same effect. It’s easier on my GI tract than regular berberine so that’s why I use it. Unfortunately, I haven’t been able to see any changes to my blood work from either berberine or dihydroberberine. I’m taking it on faith that it works. I have used Nutricost and Doublewood brands.

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#270

One of the best computer programmers follows this blueprint system of supplements, it makes sense, polypharmacy except for drug metabolism is probably a scam.

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https://x.com/ID_AA_Carmack/status/1935384635724243311#m

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#271

“And another one bites the dust.”

Good news for those who cannot afford the procedure and were experiencing FOMO.

"Plasmapheresis may backfire? :rotating_light:

A new study in healthy adults found no anti-aging benefits after 4/8 rounds of plasmapheresis—instead, some aging markers went up. #Longevity #AgingScience"

"https://x.com/TimePieChina/status/1940425241722855598

"Human clinical trial of plasmapheresis effects on biomarkers of aging (efficacy and safety trial) | Scientific Reports

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#272

Although I posted this study. It is plasma donation in middle aged people. Older people may benefit from plasma donation.

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#273

Sorry, I missed that. Still can’t currently afford it. The cost-benefit ratio doesn’t seem that good. It wouldn’t be high on my list to spend money on.

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#274

Typically you get paid for plasma donation… so you can make money from it (not spend money).

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#275

Sorry, I was thinking of receiving plasma donations from young donors.

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#276

These are not interventions I personally see as being of much use.

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#277

I still like good-old fashioned blood donation. Not the same as plasma ‘exchange’ but shedding a bag does wonders IMO

#278

There is an issue with iron overload. Best tracked watching the iron indicators. Interestingly my weekly blood draw which varies between 10 and 30ml a week is sufficient to cause mild anemia if I am drinking. Interestingly with less alcohol it may not need material iron supplementation.

#279

Yes. I run a low ferritin and mild anaemia. Fully investigated and no clear reason. Means my RCDW is on the higher side, not helped by Rapa.

But so much better than having too much iron

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#280

What sort of figures?

#281

Ferritin gets as low as 14 with an Hb of 12.2. I never notice anything until Im refused blood donation. TIBC, iron, all normal but transferrin % slightly low.
I take a course of lactoferrin and all is rectified.

RCDW has been 17.2, even when all other FBC/CBC markers are normal (but on Rapamycin).

Usually RCDW is between 13 and15.

#282

Anyone else here testing microplastic levels in their bio-samples?

Life-Extension Guru Bryan Johnson Says He Has Way More Microplastics in His Semen Than His Blood

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#283
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#284
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#285

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https://x.com/bryan_johnson/status/1952460527923519972#m

Something about this feels very wrong to me, like changing your physiology in such ways without knowing exactly what’s happening and how you’re optimizing the target. Like maybe it’s in a way that could ruin your heart. You want to know how the billiard balls are flowing in the causal chain causing the lower RHR. If RHR is all that matters, before bed time, or whatever, then there are plenty of drugs that lower heart rate but which we aren’t expecting benefit from. Those are probably very dangerous to take for Bryan… What if he gets some disease that lowers HR further, for example? Nothing is in isolation.

There’s no way RHR matters that much and actually when you cross the 80-20 pareto rule you might actually start causing harm. Goodhart’s law.

I don’t get what his doctors are doing. But I don’t know much and it might be fine actually. He recently increased his vitamin D with HBOT by like 250%, sounds he’s using powerful therapies whichever way it goes, and I’m not sure that’s good. Meanwhile you’re not going to risk nuking your body with ezetimibe, but radically improve health/lifespan if you start early. The risk-reward ratios from some of these things seem a bit skewed.

Besides if he wants to hardcore optimize his sleep he should at least use an accurate sleep tracker that measures brainwaves.

Thoughts on this?

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#286

I would say that most of us are optimizing without knowing if we are really moving the needle in terms of longevity. I also had the feeling that if you workout your heart (either exercise or IHT) you will live longer. Is there any study that supports that lower you RHR won’t give you any benefits? Or maybe it plateaus after certain point?

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#288

BJ just came out with two new hair products, a shampoo and a hair serum. Since I really haven’t done any research on hair products and have been using some random natural shampoo for years, I figured I would trust his research and just order the shampoo. Interestingly, the label says to only use 2-3 times per week so I’m going to be taking it 3x weekly and then just use my regular shampoo on the other days. I’ve always had good hair with no signs of hair loss as I approach 40 years old so I would like to keep it that way.

Anyone with more knowledge than me on hair products have any thoughts on it?

This is what I ordered

This is the other product he just came out with

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#289

I’m with you that I trust his products, so that is a solid place to start.

Not your issue, but as someone who glosses her hair, even though I think there is a benefit, I stay away from clarifying shampoos because even when their say color safe, and no matter how much you pay, they take the gloss right off.

I do trust his products do what they say they will do, but if you or anyone else ever wants to look at less expensive options, the Inky List and The Ordinary (and other brands) have various versions. There are more expensive brands offering the same.
A link to a plethora of Inky list options (none of which I’ve tried)

And a link to The Ordinary Serum containing peptides and caffeine

I do believe taking care of your scalp does give it a happy environment to have your hair flourish, but I have no idea HOW much it matters? I have been curious if the quality peptides in his or other high end brands are superior to the cheaper brands. I wonder this about skincare as well. I tend to believe they are better, but ?

Fwiw, as a preventative, that doesn’t sound like you are needing quite yet, I use minoxidil and the Musely Hair Solution Modern a few times per week. I have very long hair, so it’s very easy for me to notice any shedding. This combo makes a visible difference when I comb my hair out with conditioner in the shower.

I also would have made your choice in investing in the shampoo but not the serum. The serum might be excellent, but my theory is if I’m going to take an additional step, I want to have something that is proven to work, and that is why I didn’t bother going the serum route and went straight to rogaine.

Also, fwiw, Musely contains exosomes, as does my fav face serum, but I’ll share that our very smart @relaxedmeatball has worked with exosomes and he mentioned they have not been able to get it to penetrate the skin (I’m paraphrasing and apologize if I am mischaracterizing what he said). So, I’m thinking the exosomes are a wish but I’m no longer convinced they do anything… hopefully I’m wrong! I do wonder about putting all these chemicals that I don’t really need on my scalp, but here I am.

Latanoprost is basically Latisse, the eyelash growth serum. From experience, I know that stuff works if you only use it aprox 3x per week, and that I why I didn’t feel I needed to use Musely or Rogaine daily (however, if I had a hair loss issue, I’d bathe in it!)
Incase you are curious, here are the ingredients in the Musely serum

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Oh lastly, while I have not tried it yet, I hear tretinoin is excellent for our scalps as well. I will use it on my face and not wash my hands before using the hair serums just to get a little on there, but not enough to cause flaking/irritation

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