He didn’t cite [5] for his claim about the study with “16 epigenetic clocks”. I looked and couldn’t find it on google, anyone find it?
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adssx
#9
From what I remember, SGLT2i bring the genital infections in men to the level of women who don’t take it. And if you don’t have diabetes it’s close to zero. So the risk is very low.
Here: What's the Deal with Renewed Interest in Metformin? - #101 by Neo
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So now BJ is down to only using meme supplements and exercise? Next he’ll start going carnivore lmao.
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Dr.Bart
#11
Right ?, that was the only intervention with the most evidence bad or good… but 100 other supplements most with scant data - NO PROBLEM.
NO NEWS IS GOOD NEWS for BJ I guess.
Can’t wait for the next Optispan episode…
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AnUser
#12
Michael Lustgarten only does diet + exercise. If we have longevity drugs coming it’s worthwhile to not take too high risks that might lead to something that can kill you, like infections (sepsis).
Ezetimibe
Acarbose
Taurine
Creatine
Astaxanthin
These seem low risk? What else?
Messing with the immune system seem particularly dangerous, based on the tail effect of infection, it’s no bueno?
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No one else figured this out in the millions of years since humanity has been around. Just train and eat harder bro.
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Dr.Bart
#15
Ahh, I literally mess with the immune system every day over the years in thousands of patients over past 25 years - saved lives, improved symptoms and outcomes.
Majority of medical problems are caused by dysfunctional immune system…
BTW, anytime you take an anti-inflammatory (aspirin) you are technically messing with the immune system
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It’ll be interesting to see if BJ improves in those parameters he attributed to negative rapamycin effects.
And it is clear that rapa has different effects on different people, at least according to anecdotal evidence, where not everyone on a given protocol gets mouth sores, lipid or glucose abnormalities, skin infections etc. For some it may be a matter of adjusting the protocol, but rapa may simply not be helpful for some people. Let us remember, that even though rapa was a positive in trials with mice, that was on a cohort level, and there were those who did not benefit for whatever reason. BJ may be someone for whom rapa is a net negative.
Of course, he does take a ton of supplements and interventions, so isolating the effects of just one seems like quite a challenge.
I’m keeping an open mind. I figure there is no way to know ahead of time whether rapa will be a net positive for my health, so I just have to experiment and see. The “see” part requires extensive measuring, recording and comparison, which is why at the moment I’m doing all the baseline tests and measurements before taking rapa, which I’ll start January 2025.
We’ll see. My only serious concern is the beta cell toxicity and the interstitial lung disease.
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AnUser
#17
They didn’t have linear regression, excel sheets, diet tracking, blood tests, association and mendelian randomization studies.
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With over 100 billion people having lived (with most of them in the past 1000 years) we would expect some freak who exercises and eats in a particular way to be noted for his longevity in history books.
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AnUser
#19
Too much war, pandemics, other infections, violence, low amounts of recordkeeping, and stuff like that. Most people were farmers and had deficiencies, why would you know about someone’s great great grandpa farmer who lived to 120? Did they even count how old people became or just guessed?
I think most people ate bread also or potatoes. Not much variety to show effect from diet?
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thanks, I remember that and thought that might have been what he was referencing but that doesn’t even say what he’s claiming. The study showed rapamycin no effect on the vast majority (14 or 15) of epigenetic clocks and slight acceleration in 1 or 2 depending on the dose.
Also I’m planning on taking cat’s claw because of that study. Doesn’t seem to have any major side effects so at worst I’m only losing like 60 bucks a year.
BTW what’s your take on Dasatinib?
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Yes. He is just jumping on the anti-rapa movement. He’ll be back on in a year or two when that move will bring him more headlines.
Did you see the Masterjohn anti-Rapa bit? I think masterjohn is worth listening to but he seems to be leading the anti-Rapa charge for some nonobvious reason.
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This is an important post in the topic. Check also the very interesting time clip video with the Joan Mannick.
https://x.com/KristerKauppi/status/1857151201743372757
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AnUser
#23
What I meant with ‘messing with the immune system’, is using something with a proven increase infections or sepsis in RCT’s or observational trials – thus which might be the case for lower doses or longer use in rare circumstances.
Has anyone gotten sepsis from aspirin?
I get Masterjohn’s newsletter, but haven’t seen the anti-rapa bit. I like reading him, and have gleaned a few actionable insights when it comes to supplementing, but as with any source, you have to understand their relative strengths and weaknesses.
Masterjohn is the posterboy for mechanistic reasoning where he is second to none in his deep dives, but mechanistic reasoning is famously treacherous and highly prone to mistakes. It’s fun to read, but for more serious pointers one should look to outcome studies, I think.
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Dr.Bart
#25
The word you are probably looking for is an immunomodulator or more narrowly defined immunosuppressant.
However now that we defined it properly, there are millions of lives saved with immunomodulators/immunosuppressants.
Using immunomodulators (like any other Rx) irresponsibly is “always no bueno”
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For me, the actual lifespan data across multiple animals stands much stronger than biomarker clocks.
But Bryan is a smart guy with a smart team, so it’s definitely worth considering.
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I heard they hired professor Allan Lichtman after the election to turn the longevity keys.
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