#277

Check out this study cited in OP’s post:

Keep in mind “AC11” is cat’s claw.

#278

Are there other things you’ve done to improve your HR and HRV?

Congrats!

#279

no I do not - just take it straight up
I’ve had it measured 90 minutes after ingestion and gotten quite high levels

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#280

Exercise, earlier to bed, reducing inflammation, listening to binaural beats before bed

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#281

Why not take 6mg per week for 60-90 days a year? Then none the rest of the year?

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#282

Everyone is welcome to try whatever they want. Generally, right now, the dominant theory in the scientific community seems to be that mTORC 2 inhibition is what causes many of the undesirable side effects people see with rapamycin; immune suppression, lipid and glucose dis regulation.

mTORC2 suppression happens with frequent and “high” dose of rapamycin; the more frequent and longer, the greater the probability of this inhibition. There is no simple clinical way to measure this, so you’re sort of driving in the dark with this right now.

So, generally, its better to spread out the dosing and with do “lower dosing” - of course the big issue we all struggle with is dosing is also individual (responses vary by person), and its complex.

Anyway - read up here: Evidence that mTORC2 inhibition is detrimental, by Dudley Lamming

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#283

The inhibition of cell division whether by complex 1 or 2 would generally be unhelpful unless the objective is inhibiting the immune system.

I was planning another high dose yesterday, but have held back for now. I want to see a few markers move before taking another high dose (particularly GGT, but also track quality of sleep).

#284

Interesting, maybe I’ll try that.

#285

@RapMet
I wish I could agree but it seems my body likes a constant dose of rapamycin to function properly… hence for now I will stick to weekly 2mg. I was doing 20mg weekly before for about 6-8 weeks earlier…

@RapAdmin
I am sure I had mTORC 2 inhibition before, I remembered my 24 hour blood test was like 40ng/mL. I can’t say anything bad about it as I did not really notice anything weird.

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#286

Thx for this,

From what you gathered at your latest longevity conference, or other sources, do most people still seem to be thinking aprox 6mg once per week is the most common approach? Or are people now more commonly leaning towards every two weeks?

I’m 105lbs and taking 6 once per week.

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#287

We are similar as I too have psoriasis, which is a disease caused by an overactive immune system.

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#288

Is using AD HOMINEN a better way?

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#289

Thanks Paul. Any suggestion on good source for this? What protocol do you use?

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#290

Just search YOuTube for the term binaural beats and you will find many videos

#291

Hi again @Paul That would lead me (and others here) to just randomly selecting what to listen to. So I was hoping you might share what has been best in your experience - given your success on the heart rate and variability data.

(No worries though, with this current list I just wanted to provide color on why I think the question was valuable - for me to ask, and perhaps/likely for others on the forum to see the answer to.)

#292

I rotate through different ones
like this

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#293

He’s just dropped melatonin as well apparently: https://www.reddit.com/r/blueprint_/comments/1hb4sge/melatonin_droppped_from_protocol/

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#294

Soon it’ll be only sleep, diet and exercise.

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#295

I presume he has given no reasoning for this.

Dropping Melatonin may be a bigger mistake than dropping Rapamycin.

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#296

If we’re going to say it’s only reasonable to take a drug when there’s clinical trials showing benefits in a given population, then hardly any of the Rx drugs discussed here can be reasonably taken by healthy people. Clearly, people are inferring that these drugs will also provide benefits in healthy individuals and that healthy individuals often may better tolerate -ve side-effects.

The same goes for the risks. Where are the trials finding cutaneous bacterial infection is a side-effect of longevity-dose rapa? They don’t exist—you’re inferring that. They’ve been shown to occur in individuals taking higher, immunosuppressive doses of rapamycin (often in combination with other more powerful immunosuppressants+preexisting conditions). There aren’t subjective reports on this forum of this occurring. If they did, it would be a bigger issue in older individuals with weakened immune systems, thinner skin, preexisting conditions. Why isn’t that a concern for you? Similar reasoning goes for glucose intolerance.

Sure, a study in diseased humans is more likely to translate to translate to humans than a study in animals, but it’s still just a guess. And as far as lifespan extension, the only explicit evidence for that is going to come from animal studies. There isn’t an RCT for every drug in every population (and even if someone lies within an RCT population, it’s no guarantee that said drug will work for them).

It’s an inexact science and we’re all just making guesses on literally every decision (of course, some guesses are far better than others). But when you come in here acting like you’re obviously right (e.g yelling/caps lock and “>>>>>>>>>>>>>>>>>>>>>>>>>>”), it’s not going to provoke a nice response. Especially when you’ve made inferences yourself or just not engaged with certain points (e.g many drugs are going to be better tolerated by healthy, young individuals).

1 Like