RapMet
#222
Couldn’t agree more with everything you said. Excellent explanation @CronosTempi
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Thank you Cronos Tempi for a very thoughtful and measured response.
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JKPrime
#227
Good argument. However, Let’s assume for a moment that BJ and his doctors actually are very competent and understand that majority if not all of the rapamycin benefits can be reaped starting it later in life at age of 50+. This is extrapolating starting age from mice studies. So their thinking could be- as BJ appears to be in a very good health and clearly not yet 60, Rapamycin may actually be seen as too soon while potentially either interfering with or not benefiting his current very active and demanding health and fitness regimen. There is no frozen shoulder to cure and the muscles and strength can be still effectively build without rapa’s aid.
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The Oct. 27 pre-print Bryan mentioned is DNAm aging biomarkers are responsive: Insights from 51 longevity interventional studies in humans .
Yes - that is the paper I referred to - see the link and discussion of the paper’s weaknesses and limitations. Its not a paper that provides much value IMHO.
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Matt Kaeberlein spells out the reasons why Johnson has no credibility with me.
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Thanks @KarlT - this was a worthwhile watch.
It is amazing how slow things go in establishing what is safe and sensible.
For example, the AHA still recommends morphine for chest pain, despite the CRUSADE trial showing almost 50% increased mortality in NSTEMI and who knows on STEMI (probably worse) and in other trials of pulmonary edema/heart failure, a 5 fold increase in likelihood to need intubation, ICU and death. I use fentanyl as it is hemodynamically neutral. Suspect you do too.
So when something used since the 1950’s - so now at least 70 years of use, that is “standard of care” but is unsafe and not sensible - it is no surprise that for something that isn’t done thousands of time per day and is unsafe … how can we figure out the safety - efficacy of a much more obscure therapy?
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It would be interesting to audit one of these processes and find out where the resistance to change is. There is an inherent conservatism in people through cognitive processes, but at times you can find where the blockage is.
When I was a Member of Parliament I could find out where in the public authorities something was blocked, but without the authority to get responses in a timely manner it is all rather opaque.
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RapMet
#234
Mat seems to be looking better now than year or so ago, so whatever he is doing must be working for him. Do we know his protocol?
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JKPrime
#235
From the podcast, “Some of the things he[BJ] is doing have a potential to cause bad” well said. Further in my mind, when you are piling up all these supplements and interventions, the best thing you can do to your long term health is to stop all of them (except of when necessary to treat medical condition). Keep Mediterranean diet and exercise of course as these are scientifically proven beyond any shadow of a doubt to extend your health span.
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From this and other videos Matt has reported focusing mainly on the basics: exercise, sensible diet adequate sleep and very little to no detrimental practices. He seems to concentrate on strength training but includes adequate cardio. The things he takes has been reported as:
Rapamycin, Vitamin D, Omega-3 fatty acids, Vitamin B12, Protein in shakes, Collagen
Prebiotics — nutrients for beneficial gut bacteria — including inulin powder and chia seeds
Creatine powder and magnesium
A fairly short list.
He has reported cycling off rapamycin at times.
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RapMet
#237
Thank you @tdecicco7 . I like Matt he’s very levelheaded and stays away from hyperbole regarding the antiaging field.
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Agetron
#238
As always can never get enough of hearing Matt Kaberlein discuss real science … what we know what we don’t know… what’s possible, but is not proven. Matt really casts, I think, a very good spotlight on Bryan Johnson as a self promoter. And why Bryan’s statement on rapamycin really has no scientific basis. Or, recently learned information.
And, that possibly he is not as transparent as he keeps telling everybody… given things like his constant self-promtion… overpricing material like an MRI package by double … as he states that he is trying to make it so the average poor smuck… can do what he does for 2 million dollars… he’s providing the information, so you can do the same for $10,000. Price gouging MRI’s Its disingenuous and incongruent.
And, just as we remind each other on this website - each of us and our experiences with rapamycin is an N=1 .
Right off the bat, Bryan’s Blueprint should be suspect… his Blueprint and consultant team is his … his gender … his phenotype, blood type, epigenetics and a variety of other issues in his biological background. Not yours
Like Matt says, I agree it’s good that Bryan isn’t doing rapamycin and the world gets some of that static, cult aspect and woo-woo crap away from this very important health span and lifespan molecule.
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KarlT
#239
I am somewhat trying to figure out what motivates this guy. He’s filthy rich, so why is he trying to make money on new products?
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I think he originally had good intentions. But then it caught on and he and his team got greedy.
It’s a normal response for a businessman/millionaire.
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To be fair to him practically promoting his protocol has to run at a profit as otherwise it will be limited other than by demand.
This does however create a conflict of interest.
I think he and his team do not engage in the scientific discourse. They say things as dictats but do not appear to listen and respond.
He is also too focussed on cosmetic interventions which fix symptoms.
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adssx
#242
That’s precisely why he’s filthy rich 
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