#306

That’s the idea. I think it would probably be best to take a reasonably high dose rather than just a milligram.

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#307

Actually, Kaeberlein’s

Evaluation of off-label rapamycin use to promote healthspan in 333 adults

showed 3 times increase in skin infections among causal rapa users over non-users.

It’s a survey study (more prone to bias) and while there was a trend toward increased skin infections, it did not reach statistical significance. Did you not actually read the paper? Because otherwise it’s disingenuous to mention that finding and not qualify it.

I’m almost 31 fwiw and I’m not advocating 20 y.o’s take rapa for longevity. I wasn’t close to fully developed when I was 20 (brain being prime example).

This is just some hypothetical scenario with sound reasoning to illustrate potential for harm with very early use of rapamycin. There are other potential harmful scenarios, reduced fertility comes to mind too.
Why take the risk for a young, healthy person?

If the healthspan and lifespan added (and/or if there was slowing of aesthetic changes) are proportional to the “rapamycin-years”, then you would want to start earlier than later. To me that means 30s or 40s. Another possibility is getting most of the lifespan extension with short-term dosing later in life ( e.g Transient rapamycin treatment can increase lifespan and healthspan in middle-aged mice). The first approach obviously carries more risk of side-effects, while the second approach leaves more of the possible benefits on the table.

That’s not me advocating people take a specific approach (or that they take it at all), just laying out my personal thought process.

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#308

You do understand that p value is completely arbitrary. Typically set them at 5% or 1%, it’s just a bullshit standard. People that decide absolute truth based on made up numbers sound like cultists to me, but I digress. This is why I like looking at the actual data.

  1. 3 times as many people had skin infections in the survey
  2. There is plenty of anecdotal data that skin infections occurs with “longevity” dosing of rapamycin, and that’s coming from Matt K. the rapa King himself
  3. Dr. Green used to routinely prescribe antibiotics to his rapa patients

So are you going to continue to argue that skin infections are not more likely in healthy people taking “longevity” dosing of rapa just because the “survey” study didn’t meet the “magic” percentage?

It’s a known risk.

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#309

No duh it’s arbitrary, that doesn’t make it useless. Nobody in science thinks they can get at absolute truth, and using p values gets you closer to the truth/minimizes errors far better than “looking at the data.”

That data doesn’t conclusively demonstrate longevity rapa causes skin infections, and neither does a doctor prescribing antibiotics with it. Okay maybe there’s some anecdotal evidence, and I’m not saying that it doesn’t, but you act like it’s a closed case despite having provided very little evidence (one paper that doesn’t support your claims+”trust me bro”)

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#310

Thank you for this information. I mentioned somewhere here before my N of 1 experience - was taking 4 mg rapamycin per month, no problem. Raised to 5 mg and experienced large purulent boils such as I never had - one was on my, ahem, never mind. Previous dosing/frequency experiments ended up with aphthous ulcers, which I consider dose limiting since it is evidence of immune dysregulation, plus they hurt like hell. So back to 4 mg/month without any discernible problems. FWIW, I occasionally get a CBC, plt counts, comprehensive metabolic panels, CRP and all have been unremarkable.

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#311

Not a closed case but very simple equation.

Anecdotal evidence of risk of rapamycin and/or theoretical possibility of adverse event based on mechanism of action FAR OUTWIEGHS zero evidence (based on human studies or experience or even in theory since m-tor pathway are typically not dysfunctional in this cohort) of any benefit in a 20 year old. And BTW we were talking about 20 year olds, I saw that you tried backtracking to 30-40s.

Thus KNOWN and/or POSSIBLE RISK of rapamycin >>>>>>>>>>>>>>>>>>>>>>>>> Dubious benefit in a 20 year old human being.

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#312

Sodium hypochlorite solutions are useful to use periodically if one is prone to furuncles/carbuncles.

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#313

I’m not backtracking. You’re the one repeatedly bringing up 20 y.o.'s which is why I clarified that I’m in my 30’s.

#314

Our discussion was always about 20 year olds.

BTW, on what evidence did you use to justify starting rapamycin as a 30 year old ? .
What was the p-value in the study that proved benefit in 30 year old humans using rapamycin?
Don’t kid yourself, you are using mainly anecdotal evidence, one paper that doesn’t even apply to you and lots of bro science.

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#315

I have a bacterial skin infection right now which has probably been made exceedingly worse by being on Rapamycin. It’s cellulitis caused by 3 mosquito bites on my arm. Normally, they probably wouldn’t get infected, but that’s a downside of Rapamycin. It’s not going to kill me, but boy oh boy does it itch. My forearm is incredibly swollen.

FYI, I do blame every bacterial infection I get nowadays on Rapamycin. :stuck_out_tongue_winking_eye:

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#316

Well, my guess that most people on these forums are already maximizing their health via conventional ways - proper diet, sleep, exercise, some supplementation. So in essence most people here are pretty healthy in comparison to their peers…but healthy people don’t usually get skin infections unless they have poor circulation or diabetes.
So, yes, blaming it on an immunosuppressant is reasonable.

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#317

Anything I’ve said is only in defense of my own decision to take rapa, which you attacked early in the thread. I have zero incentive to defend a 20 y.o taking rapa, even if the logic might be similar.

BTW, on what evidence did you use to justify starting rapamycin as a 30 year old ? .

First and foremost the lifespan and healthspan studies in rodents and now marmosets, the same reason mostly everyone else here is using.

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#318

I do, too. And my own similar infections have created a limit on my use of rapa, which is why I’m so excited about the possibility of lysine being my answer. I’ll be trialing that again on my next round of rapa.

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#319

Maybe I’ll try Lysine the next time I get an infection or an outbreak of hives to see if that helps.

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#320

From my own experience Lysine is only anti-viral. and will do zilch against bacterial infections. So pretty much it depends on source of infection.

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#321

Yes. I think the hives could be viral, so lysine may help with that.

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#322

I’m sure it does if it is viral, but don’t underestimate the synergetic effect when combined with Vit C (for maximum effectiveness). From my experience either alone is nowhere near as effective as when combined.

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#323

I always take extended-release vitamin C 1 g daily at night.

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#324

unfortunate that you do not understand statistics and experimental design.
It is not a known risk for intermittent usage in healthy individuals. That is a false statement
Major problem with this “study” is it is unblinded survey from biased users who are familiar with data from immune suppressed .
Would need a placebo controlled double blind experiment to even begin to know enough to make statements about what intermittent usage does.

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#325

Thanks, I will keep this in mind if this becomes an issue, while trying to figure out a possible cause of course. I cannot remember ever suffering large furuncles (~1.5 - 2 cm). I did go through a phase during puberty where I had mild acne on face and back that would occasionally result in a carbuncle or single furuncle, but never that big as far as I can recall. Also, FWIW, the three purulent explosions I experienced were located in unusual areas, for me anyway, anterior shoulder, scrotum (!), and just above a clavicle.

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