#62

100 Billion? I think you meant 10 billion…

1 Like
#63

Believe it or not I came to same conclusion a while back as BJ (given the risks and not experiencing easily identifiable positive effects), but I do maintain a dose of 10mg every three months.

3 Likes
#64

My results posted in this forum from a single dose show the effects of rapamycin over time with the shifts in glucose, insulin and lipids. I have not had the noticeable side effects of sores and infection although you see obvious swings in WBC.

Hence either the single dose inhibits MTORC2 or thats not the mechanism.

2 Likes
#65

Rapamycin effect in inhibiting natural killer cells, is that a red flag we need to be vary of. Any old users of rapa
Have a thought to share on this.

1 Like
#66

It is hard to draw conclusions from Bryan’s n=1 choice. But these individual reports I find useful. They can help tame the hype cycle on something that still needs more study and it may encourage others to report their own negative effects.

12 Likes
#67

With all the other interventions BJ is doing, I think one possibility is that his mTOR inhibition has been stronger than one should expect. With this kind of thinking, biohackers should consider the fact that their ambition is making them underestimate the total effect on mTOR of all the interventions they do. And of course the risk that taking too many supplements and medications at the same time magnifies the risk of side effects. This is for me a one signal to be careful and not take too much, not take too many, and to use a dosing protocol that minimizes the risk for unintended effects.

12 Likes
#68

117 billion: How Many People Have Ever Lived on Earth? | PRB.

Coming back to the topic: the reasons he gave top stop rapamycin were all known when he started it so it’s surprising to me that he even start, or waited 5 years to stop. But it shows that unfortunately with rapamycin you have no way to measure the effect (contrary to a drug for hypertension, diabetes, cholesterol, etc. where at least you know it directly affects some biomarkers).

I wonder (hope?) if urolithin A can achieve the same goals without the negative side effects… Wait and see… The mTOR screening done by @Krister_Kauppi and Ora Biomedical will also help us find better and ideally safer mTOR inhibitors. If you’re able to contribute financially please consider doing so: New Crowdfunding Project Looks for a “Better Rapamycin”

17 Likes
#69

I always say it but I still want to say it, rapamycin is a double-edged sword. When used correctly, its effect is tremendous, but when used in high doses, it is harmful. This is true for all drugs. I personally take a maximum of 3mg per week. I think Bryan exaggerated rapamycin, as he does with everything else, and overdosed. In all the articles he showed, all the unwanted side effects always occurred at high doses.

9 Likes
#70

I take (including the effect of GFJ) about 25 times that amount, but much less frequently. I have posted my results in this forum. It is obvious that I am taking rapamycin as you can see the reduction in WBC and increase in glucose, but at the end of the cycle my HbA1c is 4.7%.

I don’t get mouth sores probably because of the other things I do. I think if I only took rapamycin I might suffer some negative long term side effects.

5 Likes
#71

Strange decision. Strange justification
If you do 100 Longevity impacting interventions why stop the one that is considered the “Gold Standard”?
I understand Bryan mentions issues with his Lipids, Glucose, Resting Heart Rate…
Fair enough, but at the same time his website (https://protocol.bryanjohnson.com/) shows that the measurements of all these parameters are in the “OPTIMAL/PERFECT” range.

14 Likes
#72

Anecoctal and personal data, but I get noticeably less sick and with less intensity after starting rapa. I usually had one (or two) nasty cold every year. Not anymore.

I´ve happened by chance to be on my rapa dosage day twice when symptons of COVID developed. It was so mild that I kept exercising and only discovered afterwards that it was COVID (when my kids tested positive a couple of days later).

8 Likes
#73

Do you have any youtube clip or post where he shares this?

1 Like
#74

It was some posts on his patreon awhile ago, I don’t know if he’s going to make a video about it.

You could try asking him on twitter if you want.

1 Like
#75

exactly. Daniel Tawfik pointed out that as he is also on CR, thta might be too much mTOR inhibition.

and come on. who would stop taking rapa, but cointinue taking metformin? makes no sense.

4 Likes
#76

How long have you been on rapa? What else you are on? What your blood work show in comparison? Thank you.

#77

I happened to take a monthly break on Rapamycin currently.

But I personally experienced significant benefit on gums, hair density with less graying, skin texture improvement, muscle strength and energy level.

My blood work has been normal pre and post with no meaningful changes. So I am likely to resume rapamycin after the month break. And I am not on significant other supplements. Meaning, all my input has been consistent, other than I started rapamycin one and half years’ ago.

I do take them in smaller dose but higher frequency, in part is because I have psoriasis and eczema. I take them 2x a week with 2 or 3m each so total of 6 mg on average.

Previously, I had to take prednisone on occasions or use prednisone cream for my skin.

I held the view of rapamycin is a “noise reduction” agent for me, as my psoriasis and eczema is the result of an overactive immune system.

Everything we take has a cascading effect on our system. The key is dosage. My mother had polymyalgia and RH so she took low prednisone for maintenance for a long time and it does not seem to have affected her bone density and some other key measurements.

On BJ, he has the luxury of many other experimental venues that we the average joe do not have. So rapamycin remains a top choice for me, unless my blood work proves otherwise. Also, he is on rapamycin for 5 years, if anything that is significantly negative, it would have showed up by now since he has been monitoring his blood work and all biomarkers incessantly.

I may add, the risk he is taking on all those experimental treatments, are significantly higher than rapamycin has been shown on patients on lifelong rapamycin.

Everything we do in life is, a calculated risk reward. Based on all the data out there, rapamycin remains the #1 agent for me to improve my healthspan. Again, dose is the key including the less adopted option of lower dose but more frequent use, for someone who may already has some dysfunctional issue of immune system (psoriasis).

10 Likes
#78

He doesn’t look 15 or even 30. My point is the pose (not to mention the hat and chain) is something you’d see on a 15 y.o

5 Likes
#79

I would venture to say that chronic corticosteroid dose even at lower dose poses significantly higher risk of adverse effects over time than chronic rapamycin use (at lower doses).
Chronic steroids use creates the GRU effect (I coined this term) so loss of muscle, bone density and skin thickness and central obesity along with hyperlipidemia, hypertension, metabolic disorders and tons of conditions.
image

10 Likes
#80

The fact he is having a lot of cosmetic surgery done (e.g. injecting fat into face) probably makes taking rapamycin a challenge.

7 Likes
#81

too soon to tell for myself for sure, but I just had what i thought was a cold (started seeing signs of sore throat and congestion), but basically resolved in < 24h. my colds have been extremely consistent throughout my life such that i was able to predict with basically 99.9% accuracy what the trajectory of the symptoms were gonna be based on the first hint that my throat felt something (read: severe sore throat > congestion for days > residual postnasal drip). this is probably the only/first time in my life where this trajectory did not hold true and amounted to nothing.

7 Likes