Agetron
#102
Just a thought…BJ takes a 100 supplements… has an incredible rigorous exercise routine, sleep monitoring… erection monitoring… blood injections from his son, all kinds of skin treatments… claims relationships with him are impossible, etc.
I have to think that… this one molecule - rapamycin - does as much or even more than his whole combined Blue Print.
Perhaps… throw the Blue Print out… and if you just took a little rapamycin weekly you would be competitive to live as long and as healthy as he does with all that intervention and then trying to live a typical normal life.
BJ certainly is doing more for longevity than it seems actually living… and enjoying life’s journey at times. I’m thinking I’ll probably outlive him… with strength and health to boot.
19 Likes
Dr.Bart
#103
Exactly what I have been saying, Bryan Johnson takes over 100 supplements daily. Many supplements have anti-inflammatory effects and some like curcumin and gingerol directly inhibit m-tor.
His approach is far from scientific, it’s a kitchen sink approach.
Which is fine, he’s free to do what he wants but then having him create a blueprint for others to follow based on his million dollar see what sticks plan is preposterous.
12 Likes
Any overweight genX who’s been prescribed a statin will outlive BJ.
2 Likes
helenas
#105
silicon valley and capitalism is always about adding and doing more and more, never about less unfortunately
4 Likes
Bezos, for one, is fully banking on the Yamanaka factors.
8 Likes
Bryan Johnson does too many purely cosmetic things to really know what is happening.
6 Likes
Dr.Bart
#108
Look up Attia and Kaberlein’s protocols.
1 Like
Dr. Mikhail V. Blagosklonny stated that he thought he developed cancer because there was a period where he stopped taking rapa allowing the cancer to develop. He said this in the last few months of his life. Everyone knows that the older you are the more disfuctional your mitocondria becomes so even a short period of time of not inhibiting Tor could lead to cancer. Also, Tor signal is stronger the older you become. I will try to find his statement, he was very prolific. Something to think about. I am 79, and have taken every week for years. Younger may have a different profile.
11 Likes
Dr.Bart
#110
If I was able to go back time to my 20’s, knowing what I know now I would:
- Stop excessive alcohol drinking.
- Exercise - weigh training and cardio on regular basis.
- Eat a better diet - cut sugar, eat more blue zone like… to a degree I’m only 20 years.
- Take much better care of my teeth - flossing, brushing, waterpick, etc.
- Wear more daily sunscreen and use adapalene for my Acne (and prevent wrinkles) on daily basis.
- Protect my vision and hearing.
I would NOT take rapamycin. There is very little evidence that it would be helpful this early instead of just adopting a healthy lifestyle. There is the big risk that it would actually harm me long term. WHY TAKE THE RISK when you have ZERO-RISK lifestyle changes that are proven to help healthspan and probably lifespan.
I would do the exact same thing as a female with exception - I am not sure what contraception does to longevity.
If the studies with rapamycin preventing ovary dysfunction pan out, then I am guessing that rapamycin would make sense to start for woman at maybe age 35 or 40, not 20s. Hopefully, the same studies would elucidate the best starting age.
9 Likes
JKPrime
#111
I think it was not just concern about a few biomarkers worsening but also about the lack of evidence in humans that rapa improves health span and lifespan. Further it appeared that rapa and cr didn’t make him look younger or better with his face becoming gaunt. And clearly he values his appearance a lot.
Personally I can’t take BJ seriously (just another celebrity influencer, really) due to his “approach” to supplements and meds indicating to me a lack of critical reasoning skills. More scientific potential approach would be instead discontinuing all of his supplements and medications (except of necessary ones to treat his medical issues if any) and then reintroducing them to see which one or which combination of drugs & supplements causes issues and offers benefits. Most importantly keeping the number of supplements and meds low due to potential interactions. fewer is better.
6 Likes
JKPrime
#112
Great advice! While we are on advice giving course, adding to it a bit:
-not smoking anything
-staying away from drugs
-and finding something meaningful to do and accomplish
5 Likes
He’s a scientist focused on the biology of aging, he reads all the research, and he knows that rapamycin is by far the best, most validated, most likely-effective intervention we have right now. Its not that he cares about Bryan J, its that if someone rejects rapamycin he’s likely mistaken.
See, for example:
https://x.com/Aging_Scientist/status/1853987104633856231
https://www.linkedin.com/in/kamil-pabis-b2066a84/
13 Likes
AnUser
#114
I might be correct in only testing apoB then that I used to do before. That was the only thing I tested for 2-3 years.
I want triglycerides low though because of the MR relationship with mood.
So instead of testing everything… find a few biomarkers (or many) YOU like, which you know have MR data, and optimize them.
Doing 50 blood biomarkers you’re going to have false positives and things more likely to move from an intervention in a positive or negative direction, regardless whether it was true or not?
For me:
ApoB
Triglycerides
+
(+ required when for example statin initiation).
I’ll be adding on my own list once I know with mendelian randomization data.
4 Likes
Thorin
#115
I think it is very likely that low-dose steroids increase longevity.
I think for women they may work wonders but we have not made it a priority to really dial in the timing (presumably starting at menopause) and dose and particular hormones. So I can’t say with any certainty what a woman should do or take, but I think if we studied it extensively we’d find a set of conditions (age, specific drugs, dosages) that helped.
I think for men they would also help, with the idea that men with very low androgen levels would benefit and men with normal levels would simply remain where they were to start with. (For men with normal starting levels, homeostasis would reduce endogenous production to offset the endogenous addition, resulting in little benefit or harm, perhaps.)
Obviously I am just speculating.
3 Likes
The other weird thing about his Rapamycin stoppage is that he says he’s been taking it for 5 years, he would have been around 42 then (corrected based on RapAdmin info). Listed Rapa as an intervention since 2022 (corrected as per RA)
I don’t think he connected with Dr Zolman before 2020, 4 years ago, when Oliver was 25?, he graduated in 2019 from Kings College London School of Medicine. I’d have to look back at my emails with Oliver from that time.
3 Likes
No - he was listing rapamycin on his list back in 2022 (if not earlier), and his birthday is August 1977. See this thread: Impressive Biological Age Reductions with Rapamycin (anecdotal) - #21 by AlexKChen
4 Likes
Terri
#118
For some of us, time is of the essence. It’s worth the risk/reward lotto.
5 Likes
Paul
#119
His caloric restriction could be more to blame than the rapamycin IMO, not to mention his veganism.
Probably activated both Tor complexes which Blagosklonny warned against. Always been skeptical of extreme diets.
His extreme skin routines probably also irritate his face making him prone to infections.
Compare him to Dave Pascoe who does not calorie restrict and eats meat and has a better Dunnedpace rating and IMO looks younger and healthier
12 Likes
Dr.Bart
#120
Well sure let’s add the calorie and protein restriction to the melting pot of confounding factors, including over 100 supplements, blood transfusions, and whatever else he does.
7 Likes
adriank
#121
Paid by some pharma giant… Lol. Rapamycin can’t be patented. Just like Bryan Johnson can’t make money from it. My side effects have almost all disappeared after 6 months or so. Nothing serious like the ones he mentioned. Maybe he lacks meat in his diet… Lol
5 Likes
