Indeed the data is the a 3:1 ratio of Neut/Lymph would be much worse healthwise than a 1:1 or 0.75/1 ratio. I don’t goal for “Normal” ranges as the normal man is dead at 76.1 years in the U.S. currently. I go for optimal.
I agree with @Jonas there is a consistent pattern of driving down the neutrophils a bit with Rapa and with all the other things we do. The higher your Neutrophils, typically the higher your inflammation.
10 Likes
Bicep
#143
Those are percent. I think you’re supposed to use absolute. My numbers are 3.55 and 2.17 for an NLR of 1.63. That was from a year ago.
2 Likes
LaraPo
#144
Neutrophils absolute number is 2.2 and lymphocytes absolute is 1.08. The ratio is still the same 2.03.
3 Likes
Bicep
#145
Ahh, so it doesn’t matter. The math works out the same. Glad we got that ironed out.
1 Like
DEE19
#146
Great comment! So true, among 100 of other supplements, injections, IV and other many things that became his daily, that is quick to decide rapa. Is the culprit. He pbby needs to make space to try something else that might not agree too well with rapamycin. Well, let’s wait and see what replacement his personal researchers come up with and how long before he gets back to it. Fair play to him for sharing all he is doing.
2 Likes
For those of us without infinite money for cosmetic coverups and surgery, here’s a pro tip that can make one look good without the expense. Focus on you photogenetics 
4 Likes
Is NLR now considered a “better” measure of inflammation than CRP?
adriank
#149
Exactly why he might have invested in big pharma … anyway, people who loves money, is any ever enough?
2 Likes
Dr.Bart
#150
No it doesn’t. There is real risk with taking rapamycin and no proven benefit of rapamycin in young humans. So thus. RISK>>>>BENEFIT (if there is a benefit).
There are about 2-3 human studies with rapamycin and they were all done on older folks. The positive effects were modest at best and there are real side effects even with smaller dose - cutaneous bacterial infection are no joke - they can lead to sepsis.
Wiser strategy would be to maximize healthspan/lifespan via conventional proven methods and AWAIT THE RESULTS of rapamycin studies for someone in their 20s.
Remember in rats studies rapa worked to extend lifespan even when given to middle aged rats.
5 Likes
(shrug) You’re reaching.
Just because we don’t agree with what he says, there is no need to flail around for some nefarious ulterior motive.
Also, due to the incoming administration, if anything investors are going to start shorting pharm stocks, lmao.
2 Likes
nym
#152
could you elaborate on what you mean by doing worse? we see non responders (as far as we can tell), but haven’t come across someone who feels worse on rapa. curious to hear your experience
2 Likes
adriank
#153
mainly from the side effects… example, as soon as I take my biweekly dose of 4mg, within 1 - 2 hours I will feel very tired… like going to sleep.
1 Like
adriank
#154
I agree with what you say but also, let us be realistic, the money trails never lie. When someone does something out of the ordinary, all you need to do is follow the money and you will know why. Sad but true, especially when it involves a lot of people… I am sure you know why American politicians are like rich in the order of $200+ mil USD…
There is no evidence for a “money trail” here. What Johnson is saying is not all that out of the ordinary. And it is not necessary to make the (terrible) argument that he must be corrupt, when as many here have noted, there are plenty of better arguments for disagreeing with his claims. (For example, he is taking so many other supplements etc. that he cannot possibly isolate rapa as the cause of the “hefty side effects” he attributes to it.)
3 Likes
Aaron
#156
I just wanted to share my 2cents. I have been on Rapamycin since late 2020. When I was on metformin and rapamycin at the same time I had a wicked rash that lasted for weeks - definitely too much mtor inhibition if on both. I had to take a vacation from both for a few months then gradually added the rapamycin back. I will say that high dose rapamycin does negatively affect my blood sugar and lipids if Im on a dose of 10mg a week or more.
5 Likes
Not sure, but studies in mice show an increased risk of death from infection with use of COX-inhibitors. And lots of people have died from bleeding stomach ulcers due to aspirin.
2 Likes
jnorm
#158
No it doesn’t. There is real risk with taking rapamycin and no proven benefit of rapamycin in young humans. So thus. RISK>>>>BENEFIT (if there is a benefit).
We can disagree. The exact risks and benefits aren’t even clear, so it’s pretty silly to act like the answer is that obvious. It’s clear from the animal data that the potential benefit is very significant (lifespan increase), even if the exact functional benefits aren’t clear yet.
And if the lifespan and healthspan added is proportional to the duration of rapa use (certainly possible), then it makes sense to start early.
The positive effects were modest at best and there are real side effects even with smaller dose - cutaneous bacterial infection are no joke - they can lead to sepsis.
Which is going to be more dangerous the older you get (preexisting conditions, weakened immune system, thinner skin, etc), so that’s not proving your point.
5 Likes
nikney
#159
Bryan used very high doses of rapamycin. All these effects he mentioned are due to high doses. No matter which drug you take in high doses, you will experience side effects. The important thing is to take the right dose. And I think 4mg a week for 3 months is ideal.
1 Like
Once you’ve been using Rapamycin and longevity supplements for a while, you will notice that you have remodeled your body. For me, I feel improvements in a variety of categories such as oral health, memory, circadian rhythms, mood, weight loss and energy to name a few.
Also, blood tests confirm changes in blood glucose, lipids, and other factors that you can’t feel outright.
For me it’s hard to match each supplement to each benefit. However, I do feel that Rapamycin has provided the largest benefits.
10 Likes
Here is a long text on my own personal view on Bryan Johnson’s decision to stop taking rapamycin. I think this post may be quite interesting.
https://x.com/KristerKauppi/status/1858466488987845016
15 Likes
