#1326

Anecdotally, my eGFR is consistently better now after having been on Empagliflozin a few years compared to what it was before. It wasn’t bad to begin with, but it is higher now most of the time. EGFR heavily fluctuates though.

7 Likes
#1327

Have you noticed any changes in your resting heart rate or HRV while using Mounjaro?

#1328

RHR went up a few bpm for a couple of months and then decreased back to baseline. I did start taking Ivabradine, but in theory it shouldn’t be the reason my RHR decreased since I’m typically ~50bpm and afaict from the research Ivabradine won’t lower RHR unless it’s significantly elavated.

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#1329

My experience is quite similar to dicarlo2’s. Initially, I noticed a slight increase in resting heart rate (RHR), but over time, it has decreased significantly, likely due to weight loss. In my opinion, most people wouldn’t notice a meaningful increase in RHR unless the dosage exceeds 5 mg. However, at 10 mg, I experienced a noticeable rise, which led me to reduce my dose to 7.5 mg.

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#1330

So no benefit from the Ivabradine? I started it and it seems to be lowering RHR slightly.

#1331

And @CronosTempi

I was just going to comment on this, too

I’ve been on an sglt2 for a couple of months and I keep waiting to have to urinate more often, but nope, nothing is different

I’m not diabetic

2 Likes
#1332

I’m much more confident that it helps with POTS, my tachycardia issues (and related POTS symptoms) on standing are completely resolved.

My comment about it probably not working for GLP1 induced heart rate increases was based on this post and also another that I can’t find regarding a study on ivabradine and starting RHR (I could be misremembering this one though, perhaps they looked at a different drug with heart rate lowering effects)

It could be that it helped, or my RHR just went back down on its own. Either way I continue to take it because I don’t have any side effects.

2 Likes
#1333

Yea I saw that post and the study as well, but decided to give it a shot anyway since it was already in the mail at that point. I seem to be getting a small decrease in RHR from it, but it’s possible that it is reducing other mechanisms of the increase that isn’t related to Retatrutide. Not sure.

2 Likes
#1334

I get a headache and feel “off” when I take dapagliflozin. Does anyone else get this? Is it worth trying a different -flozin?

#1335

Sometimes it feels like it increases anxiety, and other times it feels like it eases anxiety. According to studies, it reduces the activity of the sympathetic nervous system. In principle, this is a good thing, but the individual response to this in terms of mood is quite complex. For example, many antidepressants increase sympathetic nervous system activity through norepinephrine.

#1336

Is there anyone using empagliflozin? Do you think there is a difference between canagliflozin and empagliflozin in terms of effectiveness and benefits?

1 Like
#1337

Canagliflozin has more evidence from animal models for geroprotection. Empagliflozin has more evidence in humans for disease prevention (eg kidney disease, heart disease, etc). Personally I use empagliflozin because of the human evidence, but I do wonder if some of the geroprotective effects come from SGLT1-inhibition, which would favor Canagliflozin (as Empagliflozin has no SGLT1-inhibition). I’ve often considered just using both, not sure what the downsides would be though.

6 Likes
#1338

I use empagliflozin. 12.5 mg daily. I drink a lot more water and urinate more. It also helps with weight loss (except when I have all you can eat meals).

2 Likes
#1339

Is there evidence that combining canagliflozin and empagliflozin would be beneficial? I’m already on Jardiance 25 so I don’t inhibit SGLT1

1 Like
#1340

I wonder whether empagliflozin would stack well with oral minoxidil.

#1341

I’ve taken canagliflozin and empagliflozin sequentially but not together. If you took a 1/2 dose (or 1/4 dose - as this is a medication that is good for splitting) you could easily mix them and that would perhaps show some unique benefits.

I’ve also taken both with 2.5 to 5mg minoxidil with no issues (but no obvious or unique benefits).

3 Likes
#1342

Have doses above 25mg for Empagliflozin (and whatever the max is for Canagliflozin) been tested for side effects? I’d be curious if one could just combine max dose of both.

#1343

I’ve not seen, nor checked such higher doses. My general approach is to take moderate doses and do pulsed dosing (one month on, one month off) just to lower risk of side effects.

#1344

Take dapagliflozin: it is as good as empagliflozin in humans and it slightly inhibits SGLT1.

8 Likes
#1345

I recently increased my Empagliflozin dose from 12.5 mg to 25 mg. At first, I had some morning leg cramps, but they seem to have subsided. Interestingly, I’ve been hydrating a lot more during the day (mainly water and iced tea) and less in the evenings. Now my nighttime bathroom trips have dropped from a near 95% chance down to about 20% :grinning:. This was a surprise. I also introduced Telmisartan recently, so that may also be a factor.

My hunch is that the urge to front-load fluids in the morning, shortly after taking the higher Empagliflozin dose, cuts down on nocturnal urination, due to not taking on so much fluid in the evenings. All speculation, of course, but I’m hoping it continues, because I’ve had a nighttime urination habit for at least ten years, and it definitely contributed to my at best average sleep patterns.

4 Likes