#1686

Oh sorry, I didn’t say that clearly.

I meant to say, the Brenzavvy from Gethealthspan.com is more expensive than getting Forxiga from India.

1 Like
#1687

Why aren’t you getting branded Jardiance from India?

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#1688

Hey David - If I can get it covered by my health insurance at no cost, because my eGFR is 62 from blood draw two weeks ago - certainly kicking that up would be a good idea healthwise. Physician is making my case.

Mild kidney impairment - early kidney disease (Stage 2): 60-89
Under 60 is Moderate kidney impairment - kidney disease in action.

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2 Likes
#1689

Was the eGFR based on creatinine or cystatin-c? If you haven’t checked cystatin-c, then I’d highly highly recommend it because your actual GFR might be higher than you think, since resistance training and creatine supplementation can wreck your creatinine-based eGFR while a cystatin-c based eGFR is not affected by those variables.

Unfortunately, most health care providers are still unaware of cystatin-c or its superiority over standard creatinine-based eGFR, especially in specific patients who resistance train and take creatine, for instance.

6 Likes
#1690

True on both. Creatine morning and evening before workout.

Solid workout :muscle: every other day.

I actually think my GFR is fine - Jardiance can be a longevity medication, so I am going for it.

1 Like
#1691

And retatrutide is even better! There’s evidence showing that the glucagon aspect actually increases metabolism, unlike sema and tirz.

2 Likes
#1692

62 is definitely not great, if it’s your real eGFR. I’d highly recommend getting your cystatin-c checked because it’s an easy, cheap test.

5 Likes
#1693

More effective at fat burning yes. Not as good at appetite control I hear. Also not passed human trials so for people looking to play it safe tirzepatide is still an amazingly effective medication.

Welcome to the forum.

3 Likes
#1694

Bodybuilders have switched to retatrutide and even use it on bulks. I’m using 2mg a week while eating 3600cals/day for nutrient partitioning. Muscle is maintained on retatrutide.

5 Likes
#1695

Yes, but you don’t need the same level of appetite control on retatrutide.

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#1696

Welcome

Note that metabolism UP might not be good for longevity (even if it might be one way to lose weight)

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#1697

Caloric restriction promotes longevity. Drugs that make caloric restriction easier on you mentally and physically make that process easier.

I understand some people want to be able to eat more while still losing weight.

#1698

Yes, I know. But I didn’t say my objective at the present time was longevity through low mTOR activation.

My goal is to a build a reservoir of muscle. I cycle relatively short mTOR-dominant phases and longer AMPK-dominant phases. I think the often singular focus in the longevity space on the latter is a poor overall strategy.considerimg the metabolic and functional benefits of muscle tissue. So.for a few weeks, I am eating in a surplus and pausing rapamycin.

7 Likes
#1699

I’m not even sure where the notion that reta doesn’t suppress appetite as well as tirz comes from. Was it an anecdote from someone on this forum? Many variables could be at play there - dosing, source purity etc.

From my experience thus far, 3 mg a week, split dosing is making it very difficult for me to eat more than 1500 calories a day. 34M, 5’8" 156 lbs.

I chose my source from Finnrick’s Ratings.

2 Likes
#1700

Anecdotal evidence on the forums, but lots and lots of it to where it really does seem to be a real phenomenon. Hopefully this will be better quantified/examined by the forthcoming larger phase 3 reta trials. Many seem to report that it suppresses appetite but only at higher doses (6mg+ per week) compared with semaglutide/tirzepatide, but there are always exceptions such as yourself.

5 Likes
#1701

It’s also coming from high dosage tirzepatide/semaglutide users who switch. They get used to how tirzepatide works, and expect retatrutide to work the same way.

As you may know, they are not a lab. Make sure you know from which labs those COAs they publish are coming from. There are at most 2,3 US labs I would trust.

2 Likes
#1702

Just curious on how many of those anecdotes were possibly due to underdosed/bunk Reta.

1 Like
#1703

I’m doing both. Rapamycin should only really be an issue for a few days so I time it with rest days.

It is anecdotal but widespread. At the moment with incomplete human trials these user experiences hold more weight.

3 Likes
#1704

If it were underdosed/bunk, those same users wouldn’t have experienced superior weight loss despite less appetite suppression compared to tirzepatide/semaglutide. Reta has quite low affinity for the GLP-1 receptor compared to tirz/sema, so it shouldn’t be surprising that for most, it’s not as appetite suppressive. Many users seem to like the fact that compared to when they were on tirz, they can now enjoy food again but still find it easier to not overeat.

3 Likes
#1705

How do you time it exactly? Can you write out your schedule and dosing?

1 Like