LukeMV
#1908
I pretended that my previous cardiologist prescribed it to me (I was actually getting it from India) so he was fine to take over the prescription and actually supported my use for prevention. He’s a pretty good U of Miami hospital cardiologist and is up to date with research. My insurance approved it.
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Do you think that the positive results of SGLT-2 inhibitors used in the studies was determined by a regular dose approved by FDA and may not be seen with a half or quarter of the dose some people use?
I also wonder if micro dosing of GLP-1 inhibitors have the same anti-aging benefits as the regular doses.
adssx
#1910
The studies in humans are all done with FDA approved doses. I’ve never read a rationale for microdosing SGLT2i.
adssx
#1911
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adssx
#1912
Effectiveness and safety of combining SGLT2 inhibitors and GLP-1 receptor agonists in individuals with type 2 diabetes: a systematic review and meta-analysis of cohort studies 2025
We included 18 cohort studies (1,164,774 participants). In cohort studies, combination therapy was associated with a lower risk of MACE (RR 0.56 [95% CI 0.43, 0.71]; low certainty of evidence) and the kidney composite endpoint (RR 0.48 [95% CI 0.32, 0.73]; very low certainty of evidence) relative to SGLT2 inhibitor or GLP-1 RA monotherapy. Combination therapy was also associated with a lower risk of all-cause mortality (RR 0.50 [95% CI 0.40, 0.63]; low certainty of evidence), cardiovascular mortality (RR 0.26 [95% CI 0.16, 0.43]; low certainty of evidence) and hospitalisation for heart failure (RR 0.67 [95% CI 0.64, 0.71]; moderate certainty of evidence).
Pretty good.
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An SGLT2 drug, Jardiance, is now among the top ten Medicare drugs by total expenditure — and the SGLT2 inhibitor class did very well in the ITP mouse longevity studies, which I believe is a first.
So it’s clearly a valuable class and one I’ve put on my “must-have” list. If push came to shove, I’d spring for the branded American version, but I had been using Indian dapagliflozin, which recently ran out. Fortunately, I just got a prescription for another of the flozin family, bexagliflozin.
I ordered the bexa through AgelessRX — they were extremely easy to work with. I even entered the wrong address by mistake (auto-fill), and they replaced the shipment free of charge. Their prices are reasonable, and the customer service has been excellent. Highly recommended.
Depending how these numbers are intrepreted, we’re talking a top 3 ITP drug. So yeah, I’m in.
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Tom, can you share the price that AgelessRX charges for bexagliflozin?
It was $125 a month, so $4 a pill. At some point I might approach my regular PCP about it. It would be nice to have all my medicines with one physician, but rapa? E3? 17alpha? ain’t never gonna happen. But these glifozins aren’t that weird. I think bexa is $50 per month at Cuban’s Cost Plus Drugs.
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