Saúde Cardiovascular

[CJZ]

Thanks @DrFraser appreciate the advice. I’ll definitely look into the SimonOne (and not overdo the CTA’s). I got a good discount on Prenuvo but not $1250 good! I believe it was a T2 (at least it said that all over the report).

I’m targeting ApoB right in the 50-70 window, not overly focused on the bottom end and diet + lowest dose Zetia (I’m a tested hyper absorber and it made a huge difference) and lowest dose Lipitor (which I’ve been on side effect free for 15 years) keep me right in the high 50’s to low 60’s which I’m very happy with (Lp(a) negative).

Thanks!

[Ulf]

Pitavastatin is supposed to have less sides, but I got myalgia with 2 mg. Pain gone and a long break on top of that, am starting with 1 mg which should give most of the LDL-lowwring.

[Neo]

@CJZ

The CT Angiogram is a cat scan based procedure with contrast (injected IV) and computer analysis that shows the soft plaque in the arteries for analysis.

Seems like a step up from that is this new platform that Fountain Life and Terry Grossman used and top investors like Peter Thiel backed:

Cleerly's Clinical Evidence for Personalized Heart Attack Prevention

Is still only do it more seldom than MRI/MRA other not radiation type of imaging and screening

[ng0rge]

11 experts on why gains in cardiovascular disease are stalling and what we can do about it

It’s not rocket science.

“People want to prolong aging, like David Sinclair and all these guys want to come up with miracle drugs for living. But if you stop and think about it, it’s very simple,” said Joseph Wu, past president of the American Heart Association and director of the Stanford Cardiovascular Institute.

He cited the AHA’s eight essential rules: Exercise, eat a healthy diet. Don’t smoke. Get plenty of sleep, get your weight under better control. Control your cholesterol, control your blood pressure so that you don’t get a heart attack or a stroke or kidney failure. And control your glucose. “That’s the best anti-aging lifestyle,” he said.

In other words, the best medicine is prevention, a path paved by better access to health care and starting with primary care providers.

https://www.statnews.com/2024/10/15/cardiovascular-disease-rising-experts-on-causes/

@Neo

Seems like a step up from that is this new platform that Fountain Life and Terry Grossman used

Cleerly looks good. Would like to see it compared to the SimonOne test that @DrFraser recommends, as they are in a similar price range. The big advantage of CAC and CIMT tests is that they are so much cheaper.

[DeStrider]

Control your cholesterol, control your blood pressure so that you don’t get a heart attack or a stroke or kidney failure. And control your glucose.

Translation:
Bempedoic Acid, Ezetemibe, statin, telmisartan, metformin and SGLT2I.

[Neo]

@ng0rge

Cleerly looks good. Would like to see it compared to the SimonOne test that @DrFraser recommends, as they are in a similar price range

I’ll probably personally err in direction of doing the SimonOne type of MRI/MRA most years and then perhaps once a decade or so do something like Clearly/CAC that has radiation (depending on when I’ll be able to crunch my Lp(a), might do those even less often).

[L_H]

microdose! 1mg of rosuvastatin will have a big impact. The research suggests that microdosing is better than eod

[RapMet]

@Neo

I’ll probably personally err in direction of doing the SimonOne type of MRI/MRA most years

Every other year or once every three years should be just fine (save couple G’s$$$), unless you have significant changes in your health/biomarkers at which point then should be done as needed.

[RapMet]

wow so the range in % change from about 1mg to 20mg goes from about 40% at 1mg to 50% at 20mg (approx… based on above graph). Of course, it makes sense to only take 1mg then.

[L_H]

Its astonishing isn’t it. Matt Kaeberlain talks about this in his latest podcast : how the fda approval route pushes pharma to sledgehammer doses (to ensure efficacy) and has no mechanism for refining dose after approval.
Lithium is another example he gives suggesting that a therapeutic dose for longevity and brain health may be a factor of 100 lower than the current dose handed out by doctors.

[amuser]

The 10mg rosu tabs I have are tiny, impossible to split for a 1mg dose. 5mg is the smallest dose I see at goodrx. Where do you get a 1mg dose?

And isn’t the chart saying more like 25% improvement at 1mg? Is it the farthest left circle?

[mccoy]

@amuser

The 10mg rosu tabs I have are tiny, impossible to split for a 1mg dose. 5mg is the smallest dose I see at goodrx. Where do you get a 1mg dose?

The smallest dose I managed to obtain is 1.25 mg, cutting in quarters a single 5 mg Crestor pill.
Rigorously, this would constitute a mini dose, not a microdose, since the prefix micro, meaning parts one millionth smaller, would seem too much of a hyperbole.
Scraping away some material and weighing the reduced quarter with a precision scale until it reaches 1 mg would ensure the 1 mg dose but I don’t know if it is worth it.

[RapAdmin]

From this week’s Keynote speech at the Cardiometabolic Health Congress:

Sources: x.com ,

[adssx]

@L_H

i like your logic, i target 50 to 70 for much the same reason. The MR and RCTs do support down to 50 as you say. But they don’t convincingly support much below that.

FYI, apoB < 70 mg/dL is also DrLipid’s recommend target for most people who are not “high-risk”:

[Olafurpall]

Such low levels aren’t that uncommon in very healthy relatively young people. Mine was under 0.15 mg/L on my last blood test (at age 43) and so was my partner’s level (at age 40).

[Neo]

@adssx

FYI, apoB < 70 mg/dL is also DrLipid’s recommend target for most people who are not “high-risk”:

But is he optimizing for people being healthy into their 80s… or to achieve more meaningful longevity/life extension?

[John_Hemming]

I think that is because younger people have far fewer senescent cells.

[Olafurpall]

I agree that would be a part of the reason although I don’t think it’s necessarily the main reason. Having such low levels at around my age is still somewhere less than the 10th percentile or even 5th percentile if I recall, so most people around age 40 have higher levels even though their senescent cell burden should be fairly low. That said I haven’t seen a study on the senescent cell burden of humans and at what ages it really starts to increase substantially.

[CronosTempi]

A heart surgeon has a heart attack. He couldn’t believe it, and as a result almost died. One question that I have: why didn’t a heart surgeon ever get any imaging tests for the presence of plaque, and just to assess the health of his vasculature? It’s like a car mechanic who never looks under the hood of his own car.

Heart surgeon relives heart attack

Regardless of who you are, even a heart surgeon, or a medical doctor, go ahead and spend the couple of bucks for some imaging tests. A MACE can happen at any moment. Often death is the first symptom. If you have insurance on your car or house, why not spend the relative pittance to avoid the #1 killer of modern humans?

[AnUser]

I think this video partly answers why male death rate is higher on average than female. Integrating the feminine for a man might also lead to risk-taking towards longevity therapies, rather than riding motorcycles on average, maybe more productive and a true Kwisatz Haderach.