I explained the guidelines here https://mmabrasil.localizer.co/faq
and suspended him for two weeks.
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I saw the reason. Agree with it. Just couldn’t help posting the rhyming phrase.
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Autophagy is popping up everywhere. It’s possible to overdo it , but it seems to be one of the primary beneficial effects of rapamycin.
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The two most influential attributes from a gene expression basis of aging are senescence and cellular efficiency. Autophagy improves the latter.
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She’s only taking 5mg every other day. There’s a lot of room for improvement by increasing the dose. I take 20 mg a day and my apoB went from 175 to 87 mg/dl. LDL from 288 to 90 mg/dl. I was a great responder and probably not average, but you never know until you give it a fair chance.
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zazim
#133
This is a fantastic video if you really want to get in to the weeds about cholesterol. The subject is the effect of dietary cholesterol, but that is not the point of the video. It goes into great detail about cholesterol/APoB and how to lower APoB.
The answer to the question – is dietary cholesterol harmful? — is it depends. Are you a hypo responder or hyper responder or in between. My HDL is 82 so for me the answer is probably yes, harmful.
And:
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LukeMV
#134
If you do the following in addition to good nutrition and exercise, you probably won’t have to worry about cardiovascular disease
Low dose statin
Ezetimibe
Empagliflozin
Nebivolol
ARB like Telmisartan or ACE like Lisinopril
Ubiquinol + selenium combo
Probably a good idea to take Rapamycin too
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I am not convinced that HDL is a “poor man’s” indicator. Even though I try to stay on the same diet and exercise routine, my HDL varies quite a bit.
Have you tested your ApoB? I think that along with your HDL would be a better indicator.
If your ApoB is okay, I wouldn’t worry too much about your HDL as:
“HDL cholesterol is often referred to as “good” cholesterol. HDL picks up excess cholesterol in your blood and takes it back to your liver where it’s broken down and removed from your body.”
The other thing the good doctor does not really mention is BMI. The fact is that lowering BMI normally will reduce cholesterol.
It always amazes me when a healthcare advisor tells us how to lower our lipids, in general, and is obviously overweight. That is why he doesn’t mention the correlation between BMI and cholesterol levels. Yes, I know that there are exceptions due to genes, and some fat people have low cholesterol levels, but generally speaking, when you lose weight your cholesterol levels will drop.
“High BMI is associated with increased levels of LDL and cholesterol and decreased levels of HDL”
“The first step an individual can take to lower cholesterol is reaching or maintaining a moderate weight. Reaching a moderate weight decreases triglycerides in the liver and the amount of cholesterol it makes.”
https://www.mayoclinic.org/diseases-conditions/high-blood-cholesterol/in-depth/hdl-cholesterol/art-20046388#:~:text=For%20HDL%20cholesterol%2C%20or%20"good,lower%20risk%20of%20heart%20disease.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6380115/#:~:text=High%20BMI%20is%20associated%20with,and%20decreased%20levels%20of%20HDL.
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Davin8r
#136
First drug ever approved for prevention of vascular events based on an anti-inflammatory mechanism. Standard dose of cheap generic colchicine is 0.6mg, but the pharmaceutical company used a 0.5mg dose so they can patent it (granted, that’s probably the only way the studies could get done on an old medication to get it approved in the first place).
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KarlT
#137
I don’t think there is any evidence that increasing your HDL benefits you in any way.
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José
#138
FWIW
During the early part of COVID,.
I recall a small study/treatment using colchicine to treat the “inflammatory mechanism”.
The person who published/did the work was discounted and ostracized.
He was correct, yet will not be recognized.
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I saw an article around six months ago citing various studies where 0.5mg colchicine in combination with statins showed benefits for people suffering with atherosclerosis including some potential plaque reversal.
https://www.lifeextension.com/magazine/2020/8/colchicine-reduces-stroke-in-heart-attack-patients
On that basis I decided to give it a go and purchased some generic 0.5mg colchicine OTC without problems whilst on a trip to Brazil in March. I should have bought more really because I will be running out in just over a month and I can’t legally source it in the UK without a prescription. I will try to import from India in the meantime. I intend to have a further CAC scan in a few years to see whether there has been any improvement in my score.
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José
#140
From the above posted article, link to copy of on of the referenced papers, titled;
“Efficacy and Safety of Low-Dose Colchicine after Myocardial Infarction”
https://www.nejm.org/doi/10.1056/NEJMoa1912388
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I’ve seen a nice drop in ApoB, first by adding Zetia (brought me into the 60’s) then by adding Bempedoic Acid. My latest ApoB is 46mg/dL.
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What was the cost of bempedoic acid? Side effects?
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46 gives me apoB envy. I’m at mid 60s with 5mg/d rosuvastatin and ezetimibe. I’m experimenting with 10mg every other day rosuvastatin to avoid the post resistance training fatigue I get since starting rosuvastatin. The only impact of rapa in 8 weeks is my HDL increased from 40 to 60. No change to diet.
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200 tablets Bempedoic acid 180 mg $ 60 USD. Shipping charges $ 35 USD. Total $ 95 USD from our friend Anil
Sides - I have noticed mild joint pain in my elbow (which I dislocated when I was a child), but I’m not convinced it’s from the Bempedoic Acid. No other sides that I notice
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Mid sixties is good. When an oral PCSK9 inhibitor becomes available I’ll probably switch to that.
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Have you reviewed the common side effects of Bempedoic Acid?
but…
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zazim
#147
Here is a great video clearing up myths about CAC scores, including why are you should not take too much comfort in a CAC score of zero. One interesting point is that if you are taking a statin, it often will raise your CAC score, but that’s a good thing.
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