#1522

I’m relieved (thrilled really) to find a local cardiologist/lipidologist well versed in research/protocols of Sniderman and Dayspring. My LDL is high and evidence of atherosclerosis is present although age-related risk factor is very low. He has me starting on 5mg Crestor. Follow-up testing in 6wks.

5 Likes
#1523

Centenarians frequently display improved [i] glucose management and insulin signaling, as well as [ii] a more favorable plasma lipid and lipoprotein profile. They also show fewer overall signs of oxidative stress compared to aged controls [173, 174]. While a significant proportion of centenarians with diabetes also have hypertension, they tend to experience fewer diabetes-related complications, such as lower prevalence rates of peripheral arterial disease, neuropathy, and congestive heart failure [175]. Additionally, this population maintains relatively high cognitive function and physical fitness and is highly resistant to diseases, such as stroke, metabolic syndrome, and CVDs. This suggests that various factors may play a role in preventing or mitigating these adverse outcomes among centenarians. Here, it seems that the combination of a reduced production of pro-inflammatory cytokines regulated by polymorphisms in specific genes and an increase in antioxidants has a positive effect on their health status. The delay in age-induced vascular impairments observed in centenarians has been linked to improved lifestyle conditions, with healthy dietary patterns and regular physical activity. Given that dietary patterns profoundly influence the composition of gut microbiota, it can be postulated that these changes may also, at least in part, help attenuate low-grade inflammation, thereby reducing the subsequent risk of CVDs.

Centenarians—the way to healthy vascular ageing and longevity: a review from VascAgeNet

Open Access Paper:

4 Likes
#1524

Centenarians—the way to healthy vascular ageing and longevity:

a review from VascAgeNet by Sabrina Summer & Soner Dogan et al.

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Open access paper:

4 Likes
#1525

From the article:
“Genetics likely play a substantial role in this vascular resilience, with some centenarians possessing gene variants that protect against excessive inflammation, lipid accumulation, and oxidative damage”

There are so many confounding factors that are ignored when studies are done about centenarians that I tend to ignore the conclusions; as I mentioned before, they tend to have longer telomere lengths. Is this because of their lifestyle, lucky genes, the food they eat, etc.?

When they show pictures of little old men playing cards in “Blue Zones,” it doesn’t suggest that they exercise much. I can attest that, having spent time in and around various small Italian towns, I never observed much physical activity. Germans, however, do a lot of walking and have regular community Volksmarches. The Germans, on the whole, are larger than the Italians. If we took a subset of Germans who are small, how would they match up to the “Blue Zone” people?

We can ignore most of the information about current centenarians. I want to see the results for people who have exercised for most of their lives, have lived healthy lifestyles, and are not small people.

I won’t live long enough to see the results of people taking rapamycin and living what most of the people in the forum would consider healthy lifestyles.
I expect some people in this forum, an extremely small subset of the population, to live to be centenarians.

Search Labs | AI Overview
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The average height of centenarians is around 5 feet, and most are shorter than 5’5". Here are some average heights for centenarians from different countries:
Cuban men: Average 156 cm
Okinawan men: Average 148.3 cm
Okinawan women: Average 138.8 cm
Chinese women: Average 143 cm

According to available information, the average height of centenarians living in “Blue Zones” is generally considered to be around 5 feet 3 inches. This is slightly shorter than the global average, potentially due to factors like diet and lifestyle prevalent in these regions.
Key points about Blue Zones and height:
Definition of “Blue Zones”:
These are geographical regions around the world where people are reported to live exceptionally long lives due to their lifestyle habits.
Height and Blue Zones:
Studies suggest that people in Blue Zones tend to be slightly shorter on average, with a typical height around 5’3".
Possible reasons for shorter stature:
Factors like diet, which often emphasizes plant-based foods in Blue Zones, may contribute to a slightly smaller average height.

1 Like
#1526

IMG_20250106_225741
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Gonna love it!!
Delivered this morning!

5 Likes
#1527

When I first cam to Hong Kong, I towered over the local populace. In a crowd I was literally a head taller than everyone else. It was great for watching shows and fireworks as I always had an unobstructed view. Nowadays, the 20 somethings are taller than me, so it’ll be interesting to see how that impacts longevity.

Unfortunately, I probably won’t live to see the results. :stuck_out_tongue:

1 Like
#1528

Or they may have been calorie restricted in youth that kept mTOR down

3 Likes
#1529

Blue Zones may be an artifice of poor record keeping… which makes some people’s official age older than true…
So… ApoB is a risk factor for CVDz… level of Lp(a) is a risk factor for CVDz.
Why do so many studies fail to document levels of Lp(a) when presenting their results.
This failure likely makes interpretation of results less meaningful

1 Like
#1530

Found this paper interesting, conclusions;

In future research, the mechanisms of endothelial dysfunction caused by dyslipidemia should be investigated through a detailed analysis of the interactions between endothelial cells and lipid metabolism. Second, various drugs such as statins and fibrates are used to treat dyslipidemia, but these drugs also have effects on endothelial function. In the future, the development of therapeutic agents specifically for endothelial dysfunction caused by dyslipidemia is required.

4 Likes
#1531
2 Likes
#1532

I had no idea that I had serious atherosclerosis before I had a heart attack. None of the common risk factors like smoking or obesity, golden lipid numbers. In retrospect I think the stress of divorce probably had a considerable effect, though I didn’t think about it at the time.

7 Likes
#1533

What were your lipid numbers for the decade prior to the heart attack?

1 Like
#1534

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https://x.com/TSohajda/status/1876860979897581839

@AnUser: thoughts on a this to reverse plaque and solve CVD forever?

3 Likes
#1535

Nothing that ever made the doctor say “you’ve got a problem” or recommend a statin or any other kind of medication. Total cholesterol under 190, etc.

2 Likes
#1536

Prevention is guaranteed from therapies available today. Just inhibit HMGCR, NPC1L1, PCKS9, or CETP.

CVD will be solved forever with a vaccine of one or two targets above.

Other then that…

Nothing ever happens in pharma?

#1537

Thanks for your useless answer. What about my question: are cyclodextrins good?

1 Like
#1538

This has been posted before:

He says their new drug is 1000 times more powerful than cyclodextrin and safe this is key. The old cyclodextrins which I believe are able to remove cholesterol crystals and convert foam cells back into macrophages, also can remove essential cholesterol from the cilia in the ear and make you go deaf. It takes continuous use, but some of us need continual use.

The old cyclodextrins are also either with IV or enema type, both of which are a pain. Maybe these could be just an injection? And if they remove only the oxidized form and are indeed safe, then IMO this is a game changer. It remains to be seen whether we can afford them of course. Also I like to wait a while and see how it goes.

How do we know if we have a problem and need this type thing? I thought cleerly was a good answer then found out it is out of pocket $1400 and insurance covers the angiogram if your Doc orders it. Of course mine will, but it turns out not to be a completely safe thing. They put a probe up your femoral artery and inject contrast. Mail the disk to Cleerly and they use AI to say how bad it is. They talk to you over your computer for 2 hours about it. So expensive and not completely safe. Stress echo is safer. Still the decision is too expensive for the average guy who doesn’t even visit the doc and can’t afford to fix the transmission in his car, much less test for something $1400 where the odds of it being bad are probably 1/50.

So if the shot is cheap and it’s actually cheap to make then we could treat based on CAC, or just take it if it’s safe. No downside. I wanted to buy shares in this company a couple years ago but they’re private.

Cyclodextrins were good and now they’re getting MUCH better.

4 Likes
#1539

I guess RapAdmin wanted to know your actual numbers over time until your heart attack. I’m also curious. Many people here think that the cumulative LDL/apoB exposure matters. Doctors indeed only raise the alarm when it’s already too late.

3 Likes
#1540

Total cholesterol was pretty consistent in the years before the heart attack - 179, 163, 163, 184, 188, 191, 185

1 Like
#1541

Thanks a lot. And have you ever tested LDL or apoB? Total cholesterol is not very useful.