Neo
#69
Thank you for information
Neo
#70
The apoB can be felt with with a powerful choice of generally safe meds
So why choose, one could perhaps both crushed apoB and somehow lose Lp(a) over the next 2-3 before Lp(a) lowering drugs available
AnUser
#71
I don’t disagree with anything that changes total risk in positive direction.
If anything replacing saturated fat with polyunsaturated fat will have a greater decrease of apoB anyway.
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adssx
#72
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amuser
#73
From January presentation:
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Thanks for sharing. My cardiologist may have been a bit optimistic!
With your up-to-date information, do you have any idea about the indications for these drugs? I hope it’s not just limited to something like secondary prevention post-MI, but would be indicated for those with high Lp(a) for primary prevention.
AnUser
#75
As far as I remember, obicetrapib was expected to be approved sometime this year for indication of lowering LDL-C like inclisiran.
2 Likes
AnUser
#77
There’s a thread about it here as well:
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amuser
#78
Grok tells me pelarcarsen trial is for secondary prevention. Participants have lpa > 175 nmol/L.
Obicetrapib folks claim pelarcarsen likely to be priced in the $15K range.
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Lichen
#82
Here are my latest cholesterol and inflammation scores after being back in rapamycin for the last 4-5 months. My Lipoprotein(a) result of 84.20 nmol/L seems to place me in a grey zone? When combined with Apolipoprotein B of 0.92 g/L just within “normal” range I think I need to take some action.
I hear some folks here have had good success with BrilloEZ combo of ezetimibe and bempedoic acid?
Cholesterol Status
Total Cholesterol X 5.01 mmol/L
LDL Cholesterol X 3.02 mmol/L
Non HDL Cholesterol 3.46 mmol/L
HDL Cholesterol 1.55 mmol/L
Total Cholesterol : HDL 3.23 Ratio
Triglycerides 0.97 mmol/L
Triglyceride : HDL 0.6 Ratio
Apolipoprotein A1 1.44 g/L
Apolipoprotein B 0.92 g/L
Lipoprotein(a) 84.20 nmol/L
A result of >75nmol/L is considered to reflect
increased risk (Framingham data).
(Range: < 75)
ApoB : ApoA ratio 0.6 ratio (Range: < 0.7)
Inflammation
CRP HS 1.47 mg/L (Range: < 3)
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Lichen
#84
Our cholesterol and inflammation results look quite similar @Michele_Watson although I do have a much lower lp(a). Having reviewed the threads on here I have placed an order with Maulik for BrilloEZ which contains Bempedoic acid (180mg) + Ezetimibe (10mg). It can take 2-3 months to have full effect. I will report back here when I get my next blood test but could be a while.
3 Likes
Thank you! I really appreciate that.
I might try the BrilloEX (wonder if anyone on this thread is from Australia). I weigh 53 kgs and female (64 years old) I wonder if that might mean adjustments to dose? Low estrogen and low thyroid (no meds as yet) but these also contribute to my current cardio status.
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amuser
#86
Pelarcarsen phase three participant attributes -
About point 9 (interim analyses):
So even if finality isn’t expected to be reached until next year, maybe there will be some fireworks in the interim.
https://www.sciencedirect.com/science/article/pii/S0002870325001012
9 Likes
Having a low waist:hip ratio (i.e. low visceral fat) eliminated the increased CVD risk from elevated Lp(a)???
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Neo
#88
Wow.
Haven’t looked into it, but see this one somewhat related
Lipoprotein(a) and Body Mass Compound the Risk of Calcific Aortic Valve Disease
https://www.jacc.org/doi/10.1016/j.jacc.2021.11.043?
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Am very thin (0.82 WHP ratio) - so reassuring - tho will see what the stress echocardiogram test shows soon. My Lp(a) is 187. Today I started on a new bergamot formulation (Dr Mercola) and berberine. I am going to take a few natural PCSK9 inhibitors for now…for those that do not know how to calculate just measure waist then hip- then divide the waist by the hip measurement.
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