#72

https://seekingalpha.com/article/4763730-newamsterdam-pharma-significant-upside-possible-approval-obicetrapib

2025 approval in Europe? (or at least filing? So approval and launch in 2026?)

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#73

From January presentation:

obi

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#74

Thanks for sharing. My cardiologist may have been a bit optimistic!

With your up-to-date information, do you have any idea about the indications for these drugs? I hope it’s not just limited to something like secondary prevention post-MI, but would be indicated for those with high Lp(a) for primary prevention.

#75

As far as I remember, obicetrapib was expected to be approved sometime this year for indication of lowering LDL-C like inclisiran.

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#76

It sounds promising: Obicetrapib: Reversing the Tide of CETP Inhibitor Disappointments - PMC

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#77

There’s a thread about it here as well:

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#78

Grok tells me pelarcarsen trial is for secondary prevention. Participants have lpa > 175 nmol/L.

Obicetrapib folks claim pelarcarsen likely to be priced in the $15K range.

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#79

I just read this -interesting re HRT for post meno to reduce Lp(a) https://www.atherosclerosis-journal.com/article/S0021-9150(22)00183-6/fulltext

#80

Per year or what period?

#81

Per twelve month period.

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#82

Here are my latest cholesterol and inflammation scores after being back in rapamycin for the last 4-5 months. My Lipoprotein(a) result of 84.20 nmol/L seems to place me in a grey zone? When combined with Apolipoprotein B of 0.92 g/L just within “normal” range I think I need to take some action.

I hear some folks here have had good success with BrilloEZ combo of ezetimibe and bempedoic acid?

Cholesterol Status
Total Cholesterol X 5.01 mmol/L
LDL Cholesterol X 3.02 mmol/L
Non HDL Cholesterol 3.46 mmol/L
HDL Cholesterol 1.55 mmol/L
Total Cholesterol : HDL 3.23 Ratio
Triglycerides 0.97 mmol/L
Triglyceride : HDL 0.6 Ratio
Apolipoprotein A1 1.44 g/L
Apolipoprotein B 0.92 g/L

Lipoprotein(a) 84.20 nmol/L
A result of >75nmol/L is considered to reflect
increased risk (Framingham data).
(Range: < 75)

ApoB : ApoA ratio 0.6 ratio (Range: < 0.7)

Inflammation
CRP HS 1.47 mg/L (Range: < 3)

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#84

Our cholesterol and inflammation results look quite similar @Michele_Watson although I do have a much lower lp(a). Having reviewed the threads on here I have placed an order with Maulik for BrilloEZ which contains Bempedoic acid (180mg) + Ezetimibe (10mg). It can take 2-3 months to have full effect. I will report back here when I get my next blood test but could be a while.

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#85

Thank you! I really appreciate that.

I might try the BrilloEX (wonder if anyone on this thread is from Australia). I weigh 53 kgs and female (64 years old) I wonder if that might mean adjustments to dose? Low estrogen and low thyroid (no meds as yet) but these also contribute to my current cardio status.

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#86

Pelarcarsen phase three participant attributes -

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About point 9 (interim analyses):

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So even if finality isn’t expected to be reached until next year, maybe there will be some fireworks in the interim.

https://www.sciencedirect.com/science/article/pii/S0002870325001012

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#87

Having a low waist:hip ratio (i.e. low visceral fat) eliminated the increased CVD risk from elevated Lp(a)???

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#88

Wow.

Haven’t looked into it, but see this one somewhat related

Lipoprotein(a) and Body Mass Compound the Risk of Calcific Aortic Valve Disease

https://www.jacc.org/doi/10.1016/j.jacc.2021.11.043?

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#89

Am very thin (0.82 WHP ratio) - so reassuring - tho will see what the stress echocardiogram test shows soon. My Lp(a) is 187. Today I started on a new bergamot formulation (Dr Mercola) and berberine. I am going to take a few natural PCSK9 inhibitors for now…for those that do not know how to calculate just measure waist then hip- then divide the waist by the hip measurement.

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#90

Started on flaxseed- bought a small Sunbeam electric grinder - works incredibly well. Now I can grind and keep in fridge a few days to incorporate in my diet. I mixed a tespoon amt with high phenol olive oil. Tastes ok but may just put on oats as is. Am also on a good Bergamot https://www.sciencedirect.com/science/article/pii/S1756464623003249 and abt to start on Berberine all natural PCSK9 inhibitors.

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#91

Calling them “natural PCSK9 inhibitors” is overstating it IMO. A PCSK9 inhibitor nukes LDL-C by half and improves outcomes like MACE in clinical trials.

What matters as far as I know is what your apoB is and other risk factors. Have you had a call with some expert in this area of Lp(a) or taken a look at what they say?

Lustgarten decreased his Lp(a) with his customized diet and approach as well.

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#92

Hi I am at the beginning of this journey tbh. However I am going to the Cardiovascular Lipid Clinic where I live soon and will be consulting a specialist to put my name forward when the new PCSK9 drugs arrive and also to get my children tested. At the moment my doctor is dismissing my concerns tells me I am moderate risk at Lp(a) of 187. I no longer trust medical opinions tbh after being vax injured. I do what I can based on my own deeper reading and at the moment berberine and bergamot feel good. Also considering low dose aspirin (first I need to check if I have the allele variants that will make me a responder). Levothyroxine even at 25mg felt very bad. I go with my body’s signals. My doctor does not feel a statin will be that useful in my circumstances.

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