#63

20mg gives you a ~45% LDL-C reduction.

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#64

I’m trying to understand the details of this risk analysis in to actionable concepts.
There is actually a threshold pointed out by the authors, the threshold at which events ‘start to occur’, or the threshold above which ‘cardiovascular events occur’.
This threshold is identified as the 1% cumulative lifetime risk of atherosclerotic cardiovascular events. The nature of this risk is not clear. If absolute risk, then it would be the threshold above which 1% of individuals has a CV event. This corresponds to 130 mmol/ltyears in men, 150 mmol/lt for women, and it is a value pretty easy to reach after 40-50 years in men, 50-60 in women.
By the way, it appears that oestrogen reduces the transcytosis of LDL
particles into the artery wall
Values in the neighborhood of 100 mmol/ltyears in men (130 in women) are associated to practically zero risk.

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#65

Thanks! I’ll look into that. Where did you find that?

So, all the problems you had with statins are gone? And absolutely no negative effects from and Bempedoic acid and ezetimibe, berberine? Do you feel anything at all from them? You’re lipid levels are just as good? I agree with you that there is an excessive focus on just ApoB. There are so many other important factors and they all interact with each other. I’m starting to wonder about my statin too (atorvastatin 10mg), the muscle discomfort is minor, I hardly notice it, but where before I would look forward to weight lifting, now I keep putting it off…have to force myself…not sure why.

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#66

@ng0rge I can say that I feel like myself now instead of the aged version I was resigned to being. Would GG help you? It’s worth a shot. Definitely.

I do not have any known side effects from ezetimibe (my omega 3 index is 10%), or Bempedoic acid (supposedly only affects liver rather than muscle and other organs). I don’t know about my apoB since switching but my apoB was very low on rosu (48) so I’m not worrying until I have a reason to worry. I have taken berberine forever and never felt anything from it. It also doesn’t have a big beneficial effect on apoB or HbA1c either in my experience I take it for gut health mainly.

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#67

It’s into the original article

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And you can deepen that issue in the referenced articles.

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#68

“…He sells Arterosil HP (I have it on my Fullscript site cheaper)”

I’ve taken Arterosil before also and considering again. Do you feel it has the benefits they claim? What prices are you finding for the product, if I may ask.

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#69

There are two products (Designs for Health and Calroy Health Sciences) on Fullscript that use the Arterosil proprietary ingredients. They both cost $75 (down from $99 full price) for a months supply. I’m not yet taking it but I will if I need something more than I’m going now. I’ll figure that out after my next blood test.

#70

Calroy has patents on their product it seems, so there might be slight differences although hard to tell if it would be significant. What blood test would you be looking for regarding effectiveness?

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#71

@Phillipe Here are the blood tests recommended by Sr Twyman

  • Blood markers review
    • Homocysteine <10
    • GGT high means low glutathione (high oxidative stress)
    • Uric acid. High means poor metabolism. A marker of gout but also damaging to glycocalyx.
    • Oxidized LDL — 5 alarm code
    • hsCRP — good to know but if high doesn’t point to the problem
    • Myeloperoxidase (increase with infection) — HDL dysfunction
    • Boston heart panel

Of course watching HbA1c, homa-IR, apoB makes sense. I also take steps to insure sufficient nitric oxide.

And exercise (go for higher vo2max, strength, and lactate threshold) is the cure-all for mitochondrial health (beyond muscle) and keeping ROS in a healthy range.

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#72

Glucosamine/Chodroitin seems to be in that category that Norton? Attia? described as picking up a dollar in front of a tricycle: low risk/high potential reward.

I have been taking it for decades, It does help me knees. So finding it may possibly doing a whole lot more is real gravy.

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#73

Yes, glucosamine and chondroitin have been a wonder for my knees. It’s why I’ll always take it.

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