According to the doctor in this video, prescription topical rapamycin cream isn’t all that expensive.
Pat25
#486
Thoughts about this manuscript with regard to Transcutol - that many of us use in a Rapa cream. It suggests potential irreversible destructive changes in skin structure. And that increasing Transcutol concentration beyond 1% may cause unnecessary risks of skin damage, while it would not provide proportional benefits in terms of drug penetration.
It should be said that according to other publications/studies Transcutol appears to have a good safety profile. But this still made me wonder…?
“Transcutol P capability to solve lipophilic compounds
could alter the skin double layers lipid structure. Due to its
physicochemical properties, Transcutol P could penetrate
into skin rapidly which leads to co-transportation of the
significant amounts of the drug through the sample. The
high concentration of Transcutol P as a solvent could cause
irreversible destructive changes in skin structure which
can be harmful, so low concentration may be a preferable
formulation. Furthermore, almost in all parameters the
significant surge in the presence of 1 % of the enhancer
can be seen without any major difference (P value> 0.05).”
https://www.researchgate.net/publication/354957987_Effects_of_Transcutol_P_and_Precirol_ATO-5_on_Percutaneous_Absorption_of_Flutamide_from_Emulgels
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Tomorrow, I’ll send you the spreadsheet we use when developing our skin care products. If I forget… just send me a message 
Jonas
#488
Ok what do we think of the new plug for DMSO here?
Also where do you buy your DMSO?
https://x.com/PierreKory/status/1865432809050906651
I think DMSO has some effects on mRNA transcription (which is how all of this happens). It is often used as a control in experiments, but I don’t know why as it is quite active.
I buy it off Amazon.
I would say balance the hype with the science… and personally, I think anyone who describes any treatment as “miraculous” is firmly in the hype zone. Influencers who only post simplistic marketing/advertorial like content are generally people I avoid.
I think DMSO is a solvent that is a little more aggressive in terms of its results than most skin companies or people want for any length of time… here is a quote from a cosmetic dermatology textbook:
Another solvent, dimethylsulfoxide (DMSO), by contrast, is relatively aggressive and induces significant structural perturbations such as keratin denaturation and the solubilization of membrane components
See full info and quote in this post: Rapamycin for Hair Growth and Hair Pigmentation - #320 by RapAdmin
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I’ve played with DMSO and it is quite amazing in the short term. It was one of the dirty little secrets in sports injury recovery for many years.
One of my experiments was to mix a high potency THC oil in it and dropper it under the tongue to see if it would speed up the effect and it did.
One of the “issues” with DMSO topically is that it will carry whatever is on your skin deep into the dermis and into the blood stream. If your skin is not clean, it could carry harmful things past the skin barrier, it’s important to understand this effect.
Here is an old article on Sports Illustrated from 1981
2 Likes
rrrandr
#492
If you’re looking for better than odorless DMSO, add 10g of d-limonene per 8oz of DMSO. It will turn orange, and smell faintly of oranges instead of garlic. Before doing this, my wife would complain about the awful smell of “odorless” DMSO on me (apparently even the odorless DMSO turns back into garlic-stink DMSO once it’s in your body), and now she never does, even though I use it all over my head every day. D-limonene has its own suite of benefits to the body, though I’m not sure how it would affect hair, but without it DMSO is a no-go for me. If the odor is an issue for anyone else, d-limonene to the rescue!
Thanks for this recipe!
3 Likes
Agetron
#493
Welcome Roman… thanks for the tip.
Orange scent is nice… clean.
rrrandr
#494
d-limonene completely clears the garlic taste and smell of DMSO. just add 10g d-lim per 8oz of dmso, it will turn into the color and smell faintly of oranges instead. huge difference; wife-approved.
1 Like
Pupcuts
#495
Thank you so much for this! Can you share how much transcutol you used to mix up your rapa? Thanks!
hamtaro
#496
Are there any disadvantages to using a compounded Rapa pill for the cream? I’m using the agelessrx.com’s 15mg pill for my concoction.
There shouldn’t be. Though you probably want to filter out the covering or remove the capsule from the mixture and just use the powder, to remove any grittiness (not sure if the pills are tablets or capsules).
Thiago
#498
Hello
I have access to rapamune 1mg/ml here.
Any tips on how to transform it into a cream?
Thanks!
Scroll to the top and follow the instructions in this thread. also review this thread DIY Rapamycin Toothpaste and Flossing Paste
Thanks so much for this post! I realize it is a few years old now but still great! Can someone help me with the math? I am trying to figure the percentage of rapa in this mix. If I ounce equals 28350 mg. how would you figure the rapa percentage?
If you convert 1.7 oz. to mg .you get 48195 mg.
So do you divide the 6 mg of rapa by 48195 to get 0.0001244942?
That doesnt sound right. what am i doing wrong? Can someone help me? Thanks!
I would go with a simple illustration for this so we can see what some easy to do percent of the big number (48195) is That helps to understand where you are trying to get to and is a Test of ones thought process.
Test
10% of 48,195 = 4819.5
1% = 482mg (rounded up)
0.1% = 48mg
0.01% = 4.8mg
So it looks like 6 will be closer to 0.01%
In this case I’d first add the 2 together as that will be the whole;
48195 + 6 = 48201 total weight
Then divide 6 by 48201 = 0.000124
To get percent multiply 0.000124 x 100 = 0.0124% - this is the step you were missing
The test above, indicates this is the correct percent.
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Thank you so much Steve! I appreciate that.
1 Like
Pupcuts
#503
Did you end up applying the lotion once or twice a day? I just made up some but instead of 6 mg like you I used 10. Mixed that with a little trans cutal and then mixed that with 1.7 oz of Neutrogena hydro boost water cream. I just don’t remember if folks are applying it once a day or twice a day. I just got my before pictures taken and can’t wait to take after pictures in a few months!
3 Likes
In the original study they did once every day or every two days… Rapamycin May Slow Skin Aging (Drexel U. Study)
I generally used it in the evening when I went to bed, when I was using it.
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