Pat25
#476
Thanks so much for sharing Sol. That’s a pity to hear! I had my hopes up too high, I think 
. That study did look so promising, but it was only a small trial of course.
sol
#477
Don’t give up, @Pat25 . There are a lot of variables in skin issues, types, and formulas. I adjust proportions of rapa, of transcutol, how often I use it, etc. All our experiments are part of our collective growing body of knowledge.
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Pat25
#478
Thanks Sol, appreciate it. I hope you will still see an improvement!
1 Like
Jay
#479
Brett_Miller, it’s been a while since your $800 order of 30 grams of sirolimus powder from JK Chemicals. Did the order arrive in a reasonable amount of time. I ask because JK Chemicals does not have good ratings on the IndiaMart.com website. Thanks, Jay
1 Like
The order did arrive but the process was bumpy and painful, required patience and an understanding of the loosey goosey Indian approach to things (my 8 trips there helped me to understand that yes means kinda yes, tomorrow means a few weeks)…They got the address wrong and did not fix it. Whole process like 6 weeks. I will order from them again, though, to an Indian address this time…
2 Likes
shc
#481
Curious, do you have any results to report?
DrT
#482
Unfortunately no.
I noted no difference in skin tone or colour nor hair growth.
A lot of mouse results don’t translate to humans. Still, I’m only one and others might have a different result.
maleake
#483
I had to chuckle at this a little. I spent a couple of weeks in southern India about 25 years ago. As a westerner who’s used to seeing things done in a fairly orderly manner and on a time schedule, India was a continual surprise. Businesses seemed to open and close during the day at random times. For instance, one day I had to change some money and went to a bank near our hotel. It was about 2:40 pm and a guard met me at the door. “I need to change some money,” I told him. “Sorry sir, we are closed.” I was puzzled because there were bank patrons inside being waited on. But I guessed they were closing at 3:00 and didn’t want to let anyone in.
So the next day I returned mid-morning and they still weren’t open, but a little later I did catch them open. The same guy greeted me at the door. “I need to change some money,” I again told him. “Sorry sir, we don’t change money at this bank.” Of course, I wished he could have just told me that the day before so I could have avoided wasting my time.
Anyway after going to three or four other banks with no luck, I was directed to a large bank in the area. “Foreign Currency Exchange” read a big sign near the entrance. At last! I went into a long rectangular room with about eight desks lined up side by side. I filled out a bunch of paperwork and the man at desk one initialed and stamped something on one of the pages. He passed the paperwork to desk two. He too stamped a couple of pages and passed it to desk 3, and so on it went. Each clerk initialed or stamped something as it moved down the line of desks. Finally a young runner boy ran the paperwork from desk eight back to desk one. More initialing and stamping. Finally I was given a wooden token to stand in line for the bank teller who changed my US currency to rupees.
Similarly, rather than paying as you got on a bus or paying for a ticket in advance, you seated yourself and a fare taker would muscle his way though the packed bus to collect the fare from you. By then, more riders had gotten on the bus at the next stop and he had to muscle his way back through the crowd to the front of the bus to collect those fares.
I quickly realized that getting anything done in India required setting out far in advance of when I needed it. Inefficiency was built into the system because many people’s jobs seemed to rely on that very inefficiency. After a while my western mentality just surrendered to the inefficiency, relaxed and went with the flow.
It’s probably changed some since then, as India continues to modernize, but things in India definitely were different and–at least when I was there–had a very manana attitude, though I found the Indian people very nice and pleasant to speak with. They were always happy to practice their English with me. So your experience with your purchase brought back memories.
2 Likes
I looked at several research papers on topical rapamycin, and the gel formulation seemed to be more effective than cream. I wanted to ensure that the base I was using was exactly like that used in the trials. Since Hyftor was proven effective in clinical trials for angiofibroma, I decided to search for its formula, which is as follows:
HYFTOR (sirolimus topical gel) 0.2% is an mTOR inhibitor immunosuppressant for topical use. Each gram contains 2 mg of sirolimus, which is solubilized in a gel consisting of ethanol 51%, Carbomer 940, purified water, and trolamine. Each gram of gel contains 458mg of anhydrous ethanol
I found suppliers for all of the ingredients, but I suck at math and still can’t figure out how to make this using this calculator: Calculators | Lotioncrafter
I want to make 200gm. I would appreciate any help in figuring out this formula!
3 Likes
According to the doctor in this video, prescription topical rapamycin cream isn’t all that expensive.
Pat25
#486
Thoughts about this manuscript with regard to Transcutol - that many of us use in a Rapa cream. It suggests potential irreversible destructive changes in skin structure. And that increasing Transcutol concentration beyond 1% may cause unnecessary risks of skin damage, while it would not provide proportional benefits in terms of drug penetration.
It should be said that according to other publications/studies Transcutol appears to have a good safety profile. But this still made me wonder…?
“Transcutol P capability to solve lipophilic compounds
could alter the skin double layers lipid structure. Due to its
physicochemical properties, Transcutol P could penetrate
into skin rapidly which leads to co-transportation of the
significant amounts of the drug through the sample. The
high concentration of Transcutol P as a solvent could cause
irreversible destructive changes in skin structure which
can be harmful, so low concentration may be a preferable
formulation. Furthermore, almost in all parameters the
significant surge in the presence of 1 % of the enhancer
can be seen without any major difference (P value> 0.05).”
https://www.researchgate.net/publication/354957987_Effects_of_Transcutol_P_and_Precirol_ATO-5_on_Percutaneous_Absorption_of_Flutamide_from_Emulgels
1 Like
Tomorrow, I’ll send you the spreadsheet we use when developing our skin care products. If I forget… just send me a message 
Jonas
#488
Ok what do we think of the new plug for DMSO here?
Also where do you buy your DMSO?
https://x.com/PierreKory/status/1865432809050906651
I think DMSO has some effects on mRNA transcription (which is how all of this happens). It is often used as a control in experiments, but I don’t know why as it is quite active.
I buy it off Amazon.
I would say balance the hype with the science… and personally, I think anyone who describes any treatment as “miraculous” is firmly in the hype zone. Influencers who only post simplistic marketing/advertorial like content are generally people I avoid.
I think DMSO is a solvent that is a little more aggressive in terms of its results than most skin companies or people want for any length of time… here is a quote from a cosmetic dermatology textbook:
Another solvent, dimethylsulfoxide (DMSO), by contrast, is relatively aggressive and induces significant structural perturbations such as keratin denaturation and the solubilization of membrane components
See full info and quote in this post: Rapamycin for Hair Growth and Hair Pigmentation - #320 by RapAdmin
6 Likes
I’ve played with DMSO and it is quite amazing in the short term. It was one of the dirty little secrets in sports injury recovery for many years.
One of my experiments was to mix a high potency THC oil in it and dropper it under the tongue to see if it would speed up the effect and it did.
One of the “issues” with DMSO topically is that it will carry whatever is on your skin deep into the dermis and into the blood stream. If your skin is not clean, it could carry harmful things past the skin barrier, it’s important to understand this effect.
Here is an old article on Sports Illustrated from 1981
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rrrandr
#492
If you’re looking for better than odorless DMSO, add 10g of d-limonene per 8oz of DMSO. It will turn orange, and smell faintly of oranges instead of garlic. Before doing this, my wife would complain about the awful smell of “odorless” DMSO on me (apparently even the odorless DMSO turns back into garlic-stink DMSO once it’s in your body), and now she never does, even though I use it all over my head every day. D-limonene has its own suite of benefits to the body, though I’m not sure how it would affect hair, but without it DMSO is a no-go for me. If the odor is an issue for anyone else, d-limonene to the rescue!
Thanks for this recipe!
3 Likes
Agetron
#493
Welcome Roman… thanks for the tip.
Orange scent is nice… clean.
rrrandr
#494
d-limonene completely clears the garlic taste and smell of DMSO. just add 10g d-lim per 8oz of dmso, it will turn into the color and smell faintly of oranges instead. huge difference; wife-approved.
1 Like
Pupcuts
#495
Thank you so much for this! Can you share how much transcutol you used to mix up your rapa? Thanks!
