Dr Frasers AD thread got me interested in DORA’s so I asked by new best friend Perplexity a few questions about the opportunity to use peptides for this function.
One of my questions was if the sleep improvement was the key to the benefit, it is definitely part of the benefit but may not be the entire benefit from DORA’s
Since my current obsession is peptides I asked about that and found some interesting info on DSIP, my new fav peptide for increasing the quality of my sleep. One thing is does, it “concentrates” sleep patterns. We go in and out of the various stages of sleep in what looks like random cycles. It helps to concentrate deep sleep phases earlier in the sleep cycle and increase the duration of deep sleep, for me it was a significant improvement.
Deep sleep is important for clearing out the physical aspects of the brain.
dual orexin receptor inhibitors.pdf|attachment (924.9 KB)
jjrap1
#42
@Jay, Well… I did get capsules even tho’ I ordered tablets 
Oh well, I have a scale, and this is just an experiment to see if I can improve my sleep-maintenance. Sort of like what you did, I took one 10mg capsule opened it. There is 120mg of media (active ingredients + fillers) in each capsule. A white powder. Presuming the active ingredients are uniformly distributed in the filler, to get 3mg of doxepin would be 40mg of media. But there will be some loss in the capsule-making process, so I’m starting with making 3 capsules and tossing out the residual … starting below 3mg and going slow. I didn’t taste it to see if your method was tolerable.
Jay
#43
jjrap1, If 3 mg helps you get a good night’s sleep, then that is the right dose for you. I found that around 5 mg worked better for me. The scale method sounds precise and I have tried it. I also tried mixing the capsule contents with a specific amount of liquid using an oral syringe. With a 1 ml oral syringe I drew tap water and put it into a small dropper bottle 2 times for a total of 2 ml of water. (In your case it would be 3 times to get 3 doses.) I then poured the contents of the capsule in, closed the bottle and swirled the contents trying to keep the mixture near the bottom of the bottle. I let it set for a few hours for the Doxepin HCL to dissolve in the water. At that point I drew 1 ml of liquid out of the bottle as the first dose using the oral syringe. I placed the bottle in the fridge for a 2nd dose if needed. Of course, the bottle needs to be swirled before use each time. With this method some of the ingredients that are mixed with the Doxepin won’t dissolve and will coat the inside of the bottle with a white film. Assuming some of that white film to be Doxepin I thought swirling would be better than shaking in order to reduce the total amount of the white film.
The sleep is good when needed, but the unfortunate problem is that the next-day lingering sleepiness and reduced energy and stamina may hit you as it has other people on the forum. So, I try to limit use to only when needed and for a short period of time. It usually takes me a few days after this for energy and stamina to come back up to normal.
I believe hospitals commonly use Trazodone, Tempazepam and possible Silenor (Doxepin) as sleep aids, but I wonder about nursing homes. Doxepin would seem to be a good choice in a nursing home for an elderly invalid who needs good sleep and calming of nerves when next-day physical activity and alertness is not a big priority. I’m just thinking ahead about possibilities in case that’s in my future!
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