However, that is how the genome functions. It creates mRNA which is often used to create proteins. Arguably there are functions that remain within the transcription of mRNA, but if the transcription process if broken then so is everything else.
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… and taking it every day for months ≈ years.
Since we don’t really know the mechanisms, or have a real biomarker for any of the major mechanisms postulated for geroprotector agents (vs. lipid-lowering or antihypertensive drugs, etc) that we could track, focusing on mechanisms seems premature.
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I believe i know the mechanism. Hence i work on that assumption.
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It makes sense to have a framework for a strategy…such an approach keeps a person from losing focus… from emotionally leaping into too many things at the same time with no thought for how they all fit together.
Of course if everything is based on an assumed mechanism that turns out to be wrong, well…that’s unfortunate. Guess well.
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To some extent, however, if you assume a mechanism and have tools to measure whether or not you are making progress then that achieves the desired outcome. There will be subtleties of detail which will be missed.
At the moment I am comfortable that what I am doing has the desired results in the broader sense.
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Matt talks about what he believes are the most effective longevity treatments to date
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The usual - the exceptions are hormones. He feels that getting his hormones to proper levels was huge. Even more important than Rapamycin. He’ll release a video on this later.
The other notable was the list of interventions he thought weren’t worth it like Urolithin A, NR, and others.
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TRT or lifestyle interventions?
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It sounds like TRT. (20 characters)
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Interesting. I guess his buddy, Attia is getting behind this.
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Beth
#84
If I remember it correctly, he ranked creatine as one of the top things he took, yet he hasn’t had any for 6 months.
As a new adopter, I was curious why this would be because I have not heard it’s something to be cycled. Do you think life happened and he’s just lazy about it or any other thoughts?
He mentioned creatine, omega 3 and vitamin D as supplements he highly endorses.
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Beth
#86
Yes, I did watch it, thank you. I was trying to ask if you could tell why he felt it was a top supplement to take yet he stopped taking it 6 months ago. Perhaps I misheard him and should rewatch.
It indeed sound like laziness. Something I can understand because I highly resistant to protocols that require daily dosing (excluding statins) .
Does anyone know how effective is 35f of creatine weekly vs 5g every day? From my reading, people don’t recommend high doses of creatine because of water retention issues. Is that the only concern?
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Been on Creatine close to 6 months daily 5 g in the morning coffee. With a double dose 10 g on workout day… I workout every other day 1.5 hours… muscle resistance.
Feel better overall… especially in gym… have gained weight… firmer muscles… chest, arm and butt… but weight is not fat… better water retention in my muscle cells. So seems good.
When I started on rapamycin after 4 months, I lost visceral fat about 20 pounds went from 198 pounds to 178 pounds . Stabilized at 183 pounds for past 4 years. Dexa body composition shows no fat.
That said, in the past 6 months on creatine up 8 pounds to 191 pounds. Clothes fitting tightly in chest, arms and butt… but waist same.
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Yep, I’m well aware of the benefits of daily dosing. I’m trying to find out how effective once-weekly dosing is, if at all.
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Great. Just confirming for me the water weight gain has been fine.
I agree the daily intake and remembering to dose it can be an issue. Why I keep creatine and taurine next to coffee pot. Spoonful of each goes in before the Keurig cup… every morning… lol.
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Got it, OK. Yes, and the delivery mechanism is not convenient either. It’s either several pills/chewables, or powder.
I figure that for muscles gains/maintainance I can either commit to take this for the rest of my life every day, or commit to 1 more day a week of strength training. I much prefer adding 1 more weekly training session for now.
I think a scoop of powder in the coffee is the way to go. I use it daily.
