#41

Thanks. Moving discussion to DM.

#42

I finally re-read this section more carefully. I note this 99% is in lab mice, pre-clinical testing, with significant conflict of interest. With this level of conflict of interest, for a product of extensive possible payoff for the authors, I have a higher expectation of independent research, trial, and study.

That said, give me a little proof, and I’d be on my way to make my own nasal PCANS (Pathogen Capture and Neutralizing Spray), now that I have made and used @Upgeya 's formula (which is not PCANS and is based in real-world human research and trials), because I am starting to understand some of the chemistry and mechanism of action involved.

But… extraordinary claims require extraordinary proof.

#43

Update: I have mixed Carrageenan Anti-viral nasal spray using @Upgeya’s recipe, and am using it regularly when I go into exposure situations. I perceive only very mild systemic changes, and I tend toward the sensitive, so reporting for myself, I am comfortable saying I seem to tolerate it fine.

I aspire to improve on the formula over time. I am also interested in exploring making a PCANS nasal spray.

Alas, we can’t know if the formula works, unless it fails. And even then we don’t know – was the failure the formula, the application, or just bad luck? So the key question, “does it work?”, is unanswerable unless you’re running a human research trial.

While I’m basing my own use on human trials and research for the main ingredients (Iota-Carrageenan, xylitol, Povidone-iodine), PCANS doesn’t yet have a human research trial. But the mechanism of action is intriguing enough to keep it on my radar.

Speaking of aspirations, I’m considering assembling an informal team to explore antiviral DIY nasal approaches, ideally with good science backgrounds, interested in noodling this recipe, improvements, PCANS, etc. Ideally folks who know a bit about biochemistry and mechanisms of action. More than I do, anyway.

Alternatively, if you know of a DIY anti-viral nasal spray group online, tell me where? I looked and couldn’t find. (I do know about the covid nasal vaccine folks, but that was a more complicated recipe than I was able to engage with, and they seem to have gone quiet in any case.)

If you’re interested, send me a PM. If we get critical mass, we’ll take it to discord or slack or somewhere like that, and report back here if/when we have something worth sharing.

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Rapamycin as a possible treatment for Long Covid
#44

Isn’t a saline nasal rinse antiviral?

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#45

No, a saline nasal rinse is not antiviral. I think it may help relieve congestion, etc.

“While saline nasal rinses can be beneficial as an adjunctive measure to reduce symptoms and viral load, they do not possess intrinsic antiviral properties. Further research is needed to fully understand the extent of their clinical benefits and to optimize their use in viral infections.[1-2]”

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#46

Or maybe not. :frowning:

This long, very detailed post begins thus:

There is a lot of misinformation out there about nasal sprays preventing COVID-19. Unfortunately, there are no convincing studies showing that nasal sprays prevent COVID-19. The published studies investigating whether or not nasal sprays prevent COVID-19 each have major issues, which I will detail here.

I have a PhD in biochemistry and one of my PhD projects was on COVID-19. The main takeaway of this post is that there is no sound evidence that nasal sprays prevent COVID-19. Thus, nasal sprays should not be used for COVID-19 prevention in place of effective measures such as high-quality well-fitting respirators, ventilation and air purification.

https://www.reddit.com/r/ZeroCovidCommunity/comments/1iv64oi/there_is_no_convincing_evidence_that_nasal_sprays/