I don’t know whether or not it’s a great source but I’ve been taking Ergothioneine by California Gold from iHerb. I trust that brand to actually contain what it says on the label in light of the many videos by Ryker Black where he lab tests the label claims. California Gold always comes at or near the top.
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A pre-print out of China, with a notable conflict of interest (so take this with a large grain of salt):
Associations of plasma ergothioneine levels with cognitive function change in non-demented older Chinese adults: A community-based longitudinal study
Animal studies have reported that ergothioneine (ET) exert a protective effect on cognitive function, but evidence from humans remains limited. In this study, we explored the association between plasma ET levels and cognitive change in a prospective cohort study specifically focused on older adults without dementia in Shanghai. This analysis was based on 1,131 community-dwelling elder Chinese (mean age 69 years) from the Shanghai Brain Aging Study. Ultra-high-performance liquid chromatography-mass spectrometry was used to measure plasma ET at baseline. Cognitive function was assessed at baseline and follow-up (mean 2.0 years) via the Montreal Cognitive Assessment (MoCA) by trained clinicians. Multivariable linear regression evaluated ET-cognition associations with confounder adjustment. Each 1-SD increase in ET was associated with a 0.23 higher point in MoCA changes (95% CI: 0.04-0.43, P=0.021) after adjustment for age, sex, smoking, alcohol, diet score, educational level, BMI, hypertension, hyperlipidemia, diabetes, cardiovascular disease, APOE ε4 status and baseline MoCA scores. Sex-stratified analysis revealed a significant association in men (β=0.78 per SD, 95% CI: 0.35-1.21, P < 0.001), but not in women (P for interaction = 0.017). Dose-response curves indicated plateauing effects above 1000 ng/mL. Domain-specific analyses identified significant protective associations for visuospatial/executive function (β=0.08, 95% CI: 0.02-0.14) and delayed recall (β=0.11, 95% CI: 0.02-0.20). Our findings indicate that higher plasma ET levels are significantly associated with slower cognitive decline independent of confounders in non-demented community-dwelling elderly participants, with such association observed in men but not women.
Competing Interest Statement
Jiang serves as the Chairman of the Board and Chief Executive Officer of Xiamen Kingdomway Group, a company engaged in the research, development, and production of pharmaceutical ingredients and dietary supplements. The other authors declare no competing interests.
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That’s good to know. I buy a lot of their stuff because it’s the cheapest.