#526

You’re asking the wrong person about sleep :slight_smile: it’s my super power! I can sleep anytime anywhere. I have developed methods that allow me to do that though. One of the more important things to learn is to quiet the “monkey mind”. Another is being aware of tension anywhere in the body and being able to relax that and become a noodle. That goes along with the monkey mind thing

Acclimation is not like falling off a cliff and landing on, hey! I’m acclimated! certain aspects will change/normalize as you go along the path.

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#527

Elevated heart rate and disrupted sleep are incredibly common with all the GLP meds, so if anything I’d use the above as reassurance that you got the real thing. Most people do acclimate over time and find that the pros outweigh the cons. I find that taking magnesium taurate before bed helps me, but others have other tricks that work for them.

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#528

I did. Went from 5mg tirzepatide to retatrutide 2mg for 2 weeks, then 4mg for the next 2 weeks. I felt No need to titrate down tirzepatide gradually since I would be doing that naturally anyway, and it takes roughly to get it out of your system. I did gain weight during that time, then started losing again at 4mg retatrutide.

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#529
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#530

Eye opening stuff. A lot retatrutide is either overdosed, underdosed, or actually tirzepatide.

No wonder I notice appetite fluctuation with different vials

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#531

This is why I cannot take that website and it’s so-called “rankings” seriously. Their "top " sellers are single vial vendors, which happen to be :

  • 10x more expensive to buy from
  • much harder to test the quality of, because to actually test what if you got was the retatrutide, you would have to send the vial you received for testing.

Makes absolutely no sense to me. You’re not actually safer buying from these sellers. Vendor COAs are not the be blindly trusted since you cannot guarantee with absolute certainty that what’s on the COA is what you’re receiving.

#532

They don’t use vendor COAs. You send a vial to Finrick and they send it to a lab of their choice to have it tested at no cost to the sender (other than sacrificing a vial). Whether or not any given lab can be trusted is a different matter, since they use various labs which don’t necessarily have a great reputation.

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#533

I’m talking about the single vial sellers. Sometimes they’ll have COAs next to the product being sold.

That’s another issue I keep raising about them. Garbage in, garbage out.

The fact that they rate single vial sellers so highly makes me think that either :

  • they’re being paid by by those sellers
  • their methodology is flawed

Either possibility doesn’t inspire confidence.

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#534

What are some of the reasons folks switch from Tirzepatide to Retatrutide?

  • For weight loss Reta is the clear winner
  • For healthspan/longevity is the thought that Reta is also better?
    • Better Glucose control ?
    • Better inflammation control ?
    • Better protection of kidneys ?
    • Better reductions of Blood Pressure?
    • Better Cardio protection ?
    • Better liver protection ?
    • Better lipid optimization ?
    • Better Neuroprotection ?

I asked this question to ChatGPT-5:

Summary Table

Category Likely Better Drug
Glucose Control Tirzepatide
Inflammation Control Retatrutide?
Muscle Preservation Retatrutide?
Wound Healing Tirzepatide
Immunomodulation Tie
Kidney Protection Tirzepatide
Blood Pressure Retatrutide
Cardiovascular Tirzepatide
Liver Protection Retatrutide
Lipid Optimization Retatrutide
Neuroprotection Tie
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#535

At least ask your oracle to provide sources and papers. Considering we don’t have phase 3 data yet for retatrutide, I’m curious what was used to make thw conclusions about some of these categories.

#536

Yeah, ChatGPT pulls from pretty much anywhere including places like Reddit, right? I don’t trust anything it says for questions like this. Like was said, garbage in garbage out.

#537

ChatGPT was just one answer to the question but generally many seem to want to switch to Reta and I’m curious why? For weight loss it makes sense but it’s less clear to me on longevity esp given Reta is not FDA approved and seems to cause more HR elevation and arrhythmia risk.

What are some of the reasons folks switch from Tirzepatide to Retatrutide?

#538

Major reasons for me to make the switch. My liver is the weakest link.

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#539

The most common reason I’ve seen for people switching to reta (aside from improved weight loss), is improved tolerability. Fatigue is relatively common with semaglutide/tirz, not so much with reta. Arrhythmias, at least in the phase 2 study, aren’t much of an issue with reta except at the higher doses.

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#540

I actually chose my bulk source from Finnrick. I did use a single-vial source to “test” out how Reta works for me.

Haven’t used the new source yet but it came out to about $1.52/mg shipped. Not bad.

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#541

Sources for each?

#542

Switched from Tirz to Reta several months ago.

Subjective differences felt:

  • Slightly more weight loss maintained at relatively lower dose (BMI 27 on 14mg Tirz vs BMI 24.3 on 10mg Reta).
  • Less often feel too cold
  • Wake at night less often
  • Interested in eating now, but feel full quite quickly so end up eating less of any given meal. With Tirz I might forget to eat a meal but also might still over eat if dining out for example; with Reta all the meals are simply less food and over eating is less likely.

Objective measures:

  • No lab results negatively impacted, several positively impacted toward levels associated with healthspan and longevity. I test a great many markers (Fitomics makes it relatively affordable). If you have any particulars ti ask about let me know.
    ** A1c From 4.7 to 4.5 (4.9-5.1 without any GLP at higher weights)
    ** Lower triglycerides (42-53mg/dL on Tirz, 32-38mg/dL on Reta)
    ** APOB unchanged
    ** Non-HDL down (from low 70s to 53)
    ** hsCRP down (from avg 0.50 to <0.15)
    ** Uric acid slightly up from low 4s to 5.8, slightly less optimal but still normal range)
    ** Homocysteine down (avg 11 to 9.1, my optimization target is <9)
  • 195 to 180 pounds
  • waist from 36.5 to 34.5”
  • Maintained lean muscle mass
  • Resting Heart Rate: slightly elevation while increasing dose, but quite slight (67 vs 71 BMP) and returned to baseline after three months (68 BPM).

Gray market pricing for both has decreased recently. Currently have 3 years of Reta doses in the freezer.

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#543

Have you found a reliable source in Europe?

#544

bgpharma is the only reliable source I know of. He sources from Sigma Audley which has sufficiently high purity but sometimes vary in dosage.

#545

I’ve seen some complaints here that he hasn’t been shipping lately or maybe this only applies to rapamycin orders to the U.S. Have you ordered from him recently? I haven’t placed an order in over a year. Sometimes I buy items I prefer not to have on my medical record.