#7

The half-life of Rapamycin is usually considered 63 hours. So, about 2.625 days.

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#8

We have one transplant patient here taking rapamycin on a schedule similar to yours. @LaraPo has been taking rapamycin for many years on mostly a daily basis (but not every day now I believe) so she’s our local expert on this type of dosing regimen. I don’t recall her getting any significant ongoing fatigue, so it may be an issue that rapamycin is triggering due to some some unique interaction with your biology or some of the other drugs you are taking.

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#9

I was on a weekly dose for six months, starting from 1 mg per week and gradually increasing to 6 mg per week. I took rapamycin in the morning, and by the afternoon, I began to feel fatigued. This fatigue persisted throughout the next day, similar to what @DeStrider experienced. After noticing some improvements in my autoimmune issues, I decided to try my current dosing schedule based on research and anecdotal evidence. I’ve seen much better results since then: dishydrosis is in remission, dermatitis has improved by 80%, and rhinitis is probably 60-70% better. Joint pain has also decreased by around 30-40%. Although symptoms don’t return after a week, I recently had surgery and took three weeks off, during which everything came back. It took another three weeks to calm everything back down.

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#10

You are right, I don’t experience any fatigue or any bad side effects on my dose (1mg for 3 days of each week). It works well for my kidney (creatinine 0.92, BUN 15).

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#11

I took 6mg + gfc and then 2mg + gfc. No fatigue. It does trigger my gout within 12 hours, so I drink lots of water in the first 24 hours. Also I get bad smelling farts which I use active carbon pills to control.

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#12

You might want to consider the possibility of reactivated EBV.

#14

I’m also taking it for autoimmune diseases and started at 1mg every second day. By the two week mark I was in definite flare of ankylosing spondylitis and it felt like my spine was on fire. Same thing happened with a biologic treatment. There was a paradoxical pro-inflammatory response.

Then it was mentioned in a fb group I’m in and a research paper posted on the proinflammatory response that can occur. For some people it subsides as the body adjusts in two weeks or so but I ended up iller and iller and very disappointed because rapa is my last ditch effort havning reacted to so many biologics.

I quit and waited for the flare to die down, which it did, and the pain of medication induced flare is quite particular for me, and then resumed with 1mg weekly and a slow build to 3mg weekly - which seems like it should not work for AI stuff - but it is!

I’m at 3mg weekly and potentiated last dose with half a grapefruit and it’s working. My inflammatory markers are decreasing. I’m not in remission yet but I don’t expect that too quickly on this regime.

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#15

Can I ask what your new dosing schedule is please? I am experiencing severe fatigue on 2.mg twice a week . I already have bad fatigue from long covid. It’s my main reason for trying Rapamycin. But even with remaining at this same dose, I was trying to increase to 6 mg a week total. I am severely fatigued now everyday. I skipped my dose today. Thank you

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#16

I am on my forth week at 6 to 8 mg per week. And I also have this kind of deep tiredness. It does not feel bad, it is a very satisfying tired like after a long hike and a lot of sunshine. It is the next day as I general take it before bed.

Today I drank 3 strong cups of coffee to try give me some energy and it didn’t touch sides.

It is nice to imagine we are tiered because our body is working hard to clear out damaged and dead cells (autophagy) while also having to replace those. But that’s just me dreaming/making stuff up :innocent:

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#17

It does not feel bad, it is a very satisfying tired like after a long hike and a lot of sunshine.

That is the type of fatigue I like to call “Euphoric Fatigue.” It is one of the pleasant side effects of Rapamycin. I used to experience it a lot during the first year of dosing. Now, I tend to get itchy hives. Oh for the days of euphoria… :wink:

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#18

Ohhh my haha sorry to be such a tease ;). Did you up your dose? What about stopping for some months and starting again?

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#19

I did up my dose, so that may be part of the problem. I routinely had euphoric fatigue when I dosed 3 mg + GFJ weekly. It may be something that your body grows out of?

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#20

Side note: I have started taking l-taurine because it has also done the rounds in regards to health span. (10 to 15 percent life span increase in mice). It is essential amino acid that declines with age.

This seems to also have the very nice side effect of relaxing me, reducing my anxiety significantly and making me feel chill. Sometimes I take like 4 grams when I wake up way too early 4 am - makes me feel all cozy in bed and I can sleep in a bit more. (They put it in energy drinks like red bull to take the edge off).

So:

1: essential amino acid that declines with age and is important for bunch of things
2: might increase physical performance - endurance and recovery
3: life span increase
4: seems to take down anxiety/improves sleep (for me)

And it’s cheap as chips. Maybe some of the chill vibe can get attributed to rapamicin as I started almost at the same time but there seems to be clear correlation when I take taurine. I don’t think it is placebo because at this stage I have experimented with so many “promising” things I don’t think my brain can manifest any more. (Unfortunately :rofl:) Maybe worth a try to see if you can get some of that euphoric vautige back :heart::eyes:
(On empty stomach)

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#21

I do take Taurine, but since it is an MTOR activator, I wait 3 days after my Rapamycin dose before I start taking it. Unfortunately, it doesn’t bring the euphoria back.

Enjoy the euphoric fatigue while it lasts. :slight_smile:

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#22

I didn’t know that. I’ll do the same.

#23

I start taking Taurine on day 5. But I start my vitamin C and l-lysine on day 3. I am happy with 10mg per fortnight. I still have over 4.7ng/mL after 85 hours. I no longer get the side effects from before as it is far less than the 20mg a week I was taking.

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#24

I currently don’t take rapamycin since July. I think I will be off for a few months more… I will post more about this decision in my diary but my last schedule was 1mg/day for two weeks and one week off.

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#25

What’s up @scta123, my sparring partner isn’t so active any more here? Too much time spent here? :sweat_smile:

He’s riding in the Mediterranean sunset, metaphorically, enjoying maybe some wine and Luigi Fontana meals?

He escaped the Asylum, that is Rapamycin News. :innocent: :wink: Maybe it’ll look good one day again…

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#26

Yes, too much time was spent here, but my residency finished and my PhD under wraps I will have some time to spare and maybe I will be more active here again. :sweat_smile:

Everything caved in the last 6 months. I have stopped rapa in July, but continued to at least do minimal longevity effort. Some fine Luigi Fontana meals, sunsets and wine included. I am trying to find balance in all aspects of my life longevity included.

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#27

Good to hear from you! Thanks for the update.:blush:

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