You are absolutely right. I think we are taking a teaspoon.
Antioxidants are a mixed bag overall.
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High Glutathione levels are positively correlated to a long lifespan.
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Direct supplementation with glutathione has not produced any lifespan increase in animal models so far.
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You donāt supplement with glutathione. You supplement with the precursors - Glycine and NAC. This combination has shown positive lifespan extension in mice in the Baylor University trials.
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Neo
#191
I see a lot of potential here DeStrider. What are your thoughts on potential risks?
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Right now, Iām choosing to supplement with GlyNAC (1g) as I have multiple polymorphisms in the GSTP1 gene. I canāt say that Iāve noticed any difference but Iām taking it more as a preventative measure (I live in a highly polluted area with poor air quality and genes that indicate that I donāt produce glutathione in the lungs as effectively).
I did have my HS CRP tested recently which came out at 0.15. I found this surprising given my exposure to so many pollutants and irritants on a daily basis! I canāt confidently attribute it to the GlyNAC supplementation as I didnāt establish a baseline level prior to supplementing but it did cross my mind due to its anti inflammatory properties.
Iām new to the forum and not taking rapamycin right now (Iām 24) but plan to start at around ~27. I still have a lot of muscle to build after years of neglecting the gym 
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As far as I know, Glycine by itself does not have many (any?) notable risks and has been shown to extend lifespan by the ITP.
NAC has a lot of benefits including positive mood effects and helps break bad habits and addictions. There is a concern that it may protect lung cancer cells since it protects all lung cells from damage. The odds of this are low but not negligible.
Overall though, GLYNAC should be especially beneficial to those over the age of 45.
Neo
#194
Thanks a bunch @DeStrider , helpful! Started glycine ahead of sleep (and had been getting some via collagen). Will look into the NAC a bit more and perhaps combine.
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Bicep
#195
High doses of NAC gave me a-fib. I waited awhile and used smaller doses and it gave me irregular heartbeat. Iāve decided to not use it.
Before I had the trouble I did the whole glynac thing for the 12 weeks ( I think it was 12). I thought it worked.
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@Bicep Sorry to hear that. Not everything works for everyone. Just like statins didnāt work for me, GLYNAC may not work for you. Itās best to not keep trying things that donāt work for your individual biology and to stick with things that work for you.
You could try Glycine on its own.
Neo
#197
Wow, sounds a bit scary. Sorry to hear. Do you know if there is a mechanistic reason for such a side effect?
@Bicep I was listening to Masterjohn last night say that the body doesnāt like serine floating around in the blood so it stores it in glutathione in the liver (as a sink) or converts to other amino acids such as taurine. Perhaps the excess serine was bothering you. Iām going to do an interview with Ross Pelton on glutathione today.
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Serine is a glutathione precursor. Itās also a carcinogen. Glycine can replace serine in glutathione production.
I had not heard that glycine could substitute for serine. If true, why is everyone taking glycine and NAC to support glutathione?
Glycine + NAC (or serine) + glutamate = Glutathione
The limiting precursors are glycine and NAC. Your body has way too much glutamate so no need to supplement that. Actually part of the benefit is getting rid of excess glutamate which is cancer food.
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tananth
#202
Actually the limiting factor is the enzyme that combines NAC/cysteine + glutamate : This enzyme progressively decreases with age and hence you need to supplement with more and more NAC as you age. Eventually you will need 9g of NAC/day (for a 70kg body weight) and most people have digestive problems once you exceed 3g of NAC/day and some have more serious side effects.
The only workaround is to supplement with GGC (Gamma Glutamylcystein), the product of NAC/cysteine + glutamate that is normally produced in all cells. Unlike the end product Gluthathione, which cannot be absorbed by most cells in the body (since there is no pump mechanism to absorb Gluthathione), GGC is readily absorbed by all cells by osmosis and rapidly converted to Gluthathione since the 2nd step (GGC + Glycine = Gluthathione) does not have problems with the enzyme decreasing with age. You only need around 400mg of GGC twice daily so there is no risk of digestive upset or other side effects. The main drawback with GGC supplementation is that there seems to be only a single seller of GGC (Continual-G) and it is expensive : $1.50 per 400mg dose, so $3.00 per day. I take 4 doses a day since it dramatically improved my memory after a TIA episode : The effect was within hours of taking my first dose and I have no idea how it works, but it definitely proves that GGC crosses the BBB.
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Vlasko
#203
The research is limited, but some people are taking glycine along with NACET instead of large amounts of NAC or expensive Continual-G. I wish there was more info available showing lack of toxicity with repeated dosing. It is also rapidly taken up by cells. So itās unclear how often it should be dosed. I did try it for a short time. But I now think more research is needed.
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From a quick read, it does appear that NACET may be superior to NAC due to higher bioavailability. It also seems to have a beneficial effect on glutathione. I may want to try it instead of NAC. I also like that it can cross the BBB.
I also found this write-up which appears to be factual.
I have decided to try it, as I respond very well to my current NAC supplement. This is the one I just purchased. Thereās a $10 USD coupon right now, so the cost is quite comparable to what I would pay for NAC. 200 mg of NACET = 2 g of NAC.
https://www.amazon.com/dp/B0BFZN9ZPB?psc=1&smid=A2J33NKR0GEERM&ref_=chk_typ_imgToDp
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Neo
#205
Do you know if there are any good tests to look into to measure impact of (Gly)NAC?
