In general, making claims that are highly speculative and far fetched and with holes in their logic, requires that you support them, or else you’re not really providing any value with your posts.
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Thank you for bringing this information to our attention.
As someone who knows nothing about either of these and not likely to take them in the near term, it would be helpful in general to paste a few of these supporting studies in your post so people can follow. If it is really very easy to find these sources then it should be very easy to post them for those of is who are not as invested here. If you do, then this forum continues to be a source of great information which is easy to digest. If you don’t, acknowledge that people are less likely to take your arguments as seriously (even if they are correct”) because there are no sources and just sound like an argument rather than a discussion.
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murraci
#250
My post included a sum total of four linked studies.
It did. But none of them make a good case for your statements that glucosamine or ashwagandha increase autophagy and inhibit mTOR, or that NAC inhibits autophagy, in humans. You can talk all you want about worms and in vitro studies, but in the end you have to put things into context to really see if there are any reasonable chances of this applying to humans ingesting these compounds at normal intakes. After all, we are not worms or cells in cell culture.
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GLYNAC is the very first topic.
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Jonas
#254
How do you restrict methionine in daily life?
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murraci
#255
Yes I share his scepticism re the results only being from one lab. Particularly, as I said before, when that lab has a patent on it.
He’s not that skeptical. He thinks it’s great. The ITP will be testing GLYNAC, so we’ll have much better data in a few years.
murraci
#257
“since all these data come from one laboratory, I would like to see more data from independent sources”.
“I share his scepticism re the results only being from one lab”
Your first statement is true that all the data comes from one lab at a respected medical university. He is still a proponent of GLYNAC. I just don’t feel that he’s skeptical. He just wants more data. As do we all on every protocol we are interested in.
We’re probably arguing semantics at this point. I’ll continue to take GLYNAC along with my parents as my parents have seen some really impressive results on HBA1C and GSH.
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How do you restrict methionine in daily life?
I listened to a doctor podcast a week ago that supplementing with excess glycine — and likely the GlyNAC protocol — will offset methionine levels in a safe way (turning it to glutathione). The doctor wasnt suggesting superhuman levels of glycine. Glycine has been shown to be safe for periods up to a month at 90g daily, so ridiculous high (according to a healthline post i attached somewhere here).
I’m not sure if there is another way. This one makes sense to me in my life. So my plan is to take extra glycine and collagen. I’m right now taking 6g glycine and 30g collagen daily; maybe ill increase a bit, but this might be enough to offset.
Just my “WAG” so not medical advice (im not a doc anyway); I am on a high animal protein low carb (not zero, and sometimes switch it up) diet with one-meal-per-day many days, and four-day water fasts every 1.5 months. I’m not yet taking rapamycin but definitely will. And i exercise with lots of flights of stairs (like 300 flights per week) and heavy lifting (endurance training only didn’t really change me much but the heavy lifting changed me substantially).
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Here’s a short on Glycine.
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I’m curious if anyone has looked into pros/cons of taking glycine individually vs collagen. If so, can you share the findings?
I personally like to keep things simple, so I just take collagen and assume that glycine I’m getting from it is just as good. Plus, there may be additional benefits to collagen peptides (though that’s less clear). But I don’t have a good understanding of physiology/biochemistry, so I don’t know if there is a reason to doubt whether the anti-aging effect is still there.
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Also, the same question goes to Gelatin. E.g., Knox Original Unflavored Gelatin (32 ct Packets) is only $12.26 on Amazon.
Not a clinical trial, but when i started 3g glycine i felt a “flush”; this is a common initial side effect that goes away when your body is used to the dose. When i started 30g collagen i felt no difference, nor with large amounts of meat or skin. .so something different seems to be happening when glycine is administered separately. But I’m not sure if this is critical for reducing methionine or increasing glutathione. So no idea.
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Also, the key with any amino acid is to take it in a liquid on an empty stomach. If you are eating other proteins or a meal, the other food will prevent some of the aminos from being absorbed. So, you may think you are getting a lot of amino acids like Glycine from meat or other Glycine heavy products, but you may not be getting as much as you think you are.
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Thank you for sharing!
A question for those who have researched good glycine brands: could you please share your favorites? Thanks!
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José
#266
FWIW
I use pure glycine powder, water soluble.
Marketed/sold by microingredients sold in 1 kg/2.2lb bag
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I have used Glycine powder from NOW, Bulk supplements and Micro ingredients. The first two have been tested by Consumer lab and found to be excellent. So I am now purchasing from BulkSupplements, but I believe all 3 are good. I buy the powder since you need quantity on this one.
