Honest feedback is best. I could just be an old fool with wishful thinking.
Lets start with the assumption that my hypothesis is correct and that the main problem with aging is that the genome stops functioning properly and hence produces too few of the proteins (particularly more complex ones) that it should. (potentially none).
This gradually causes malfunctions at a macro level. If you fix it, however, it does not mean that suddenly everything will change. What changes is that the cells start functioning more effectively (and that I think is gradual because of the interplay between histone acetylation and DNA methylation).
So where you have cells that are not active nothing changes. When it comes to things like maintaining skin flexibility cells with a bad blood supply (such as on the shin) don’t really change that much. Other cells, however, start rebuilding the extra cellular matrix (as long as there are sufficient materials).
Hence you would not expect a sudden change as if someone is placed into a device which suddenly makes them look 40 years younger.
I am deliberately avoiding cosmetic interventions as I wish to monitor what happens without cosmetic interventions. Obviously if I used the cosmetic interventions they would add to what I have been doing.
I am also more concerned about substance than appearance. Hence the fact as far as I can tell I am not becoming frail, but instead becoming more robust is good. For example I would like to find a way of measuring CRP with a sensitivity below 0.15 mg/L as my CRP is now below that figure.
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invivo
#23
There is a challenge with using data from a community that is not randomly controlled, yes; no less with the selection bias of folks optimizing for proper health. As you mention, QOL metrics are a nice addition, but not sufficient on their own. Compelling data would involve tracking physiological measures, as well as incidence of chronic disease over a longer period of time. We’re actually writing a post relevant to this right now!
-Alex K
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invivo
#25
Don’t get me wrong - thinking about theory of aging is fascinating and we talk about it all the time as a team purely for fun. I’m not sure a theory first approach will be a path forward for this field, though. We will very soon be releasing some posts that offer interesting and varied perspectives on emerging science trees to treat age related disease. Stay tuned!!
-Alex K
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The idea of mitochondrial transplantation represented by Mitrix Bio - see here: Highlights from the 2023 Longevity Summit
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If you are looking for synergistic effects you need to have some idea as to the mechanisms you are trying to influence otherwise you end up with pot luck on combinations as the ITP are finding.
In any event I do a lot of testing and have a lot of positive results. I developed the theoretical analysis based both on papers from others and my own results.
Hi Invivo, I have a bit of a different view on this that I will share with you for what it’s worth.
First, I don’t think we will ever find a single intervention that will do what you suggest. Like looking after a car; if you want it to stay in good nick, there are lots of things that need regularly attending to.
Second is I think if your aim is profit, you are missing your major market in your current plan. Staying young is much more important to women than men.
This is not just vanity. Like it or not, women’s worth in our society is directly linked to us looking young and staying thin.
Women generally will do much more to attain these goals than men. Look at all the clinics that have sprung up where women pay hundreds of dollars to get injections in their lips.
Instead of simply investing in research–which is still great–I would suggest you need to invest in people. Influencers who are not doctors or science geeks - but women who are turning back the clock have an enormous potential audience these days to promote the concept of health span along with tons of products, exercises, treatments etc. that unlike Ozempic, are genuinely good for their health. There is plenty of room for a new Oprah, and what is she worth to her producers?
There are already women doing this but too often it gets bogged down in science (and conflicting science) and gets boring and takes too much time. What you need are women who are genuinely turning back the clock sharing what they are doing without trying too hard to convince people with anything but genuine results. It also need to be produced extremely well so it stays fun.
I wish I had started 3 years ago and I could have documented a ton of stuff on camera that I have done that has taken me from looking like and old women to being mistaken for my 24 year old son’s girlfriend LOL.
What bit of what I did go the results? I will probably never know, But it certainly had to do with exercise and sunshine and not just suppliments and drugs!
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Curious
#29
14 AMPK activators are rather many. May I ask which one you use and how you rank their importance?
When running AMPK activation using those I take them all and have not got a sequence of importance. A lot are TCM Yang Qi herbs cf ginseng
@John_Hemming “My own protocol has apart from Rapamycin and Citrate over 15 HDAC inhibitors and over 14 AMPK activators as well as ATP boosters and other interventions.”
Do you make an effort to cycle your interventions to avoid counteracting effects? AMPK activators vs mTOR activators?
Do you have overlapping tools for HDAC inhibitors and AMPK inhibitors (and getting phytonutrients for the gut)? The normal lists seem to include many of the same plants or plant components.
I do cycle things. At the moment I am running quite a minimalist level.
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