Greg Fahy: We may have discussed what this guy is doing but can we talk more about him

[Beth]

Well if that is not logic, I don’t know what is

In all seriousness, my goal is simply to make sure I’m benefiting from the good things taurine/mag/glycine have to offer… but yes, whatever I’m doing is working beautifully for sleep!!!

[RPS]

Well you can also take some taurine first thing in the morning as well so as not to miss out on any extra benefits of that.
For those on a tight budget maybe one needs to experiment with the end of day protocol, but in your case, as you appear to have it just right, don’t go changing anything.
If it ain’t broke, don’t fix it !!

[Agetron]

I just received my GlycanAge results. This test measures your inflammation levels. As promised here are the results.

Based on glycans and inflammation - I rate at 46 years old biological age. That is 21 years younger than my chronological age.

Continuing the same amazing levels from my previous test in December 2024 - also 21 years younger biologically.

When I asked the researchers how many of their clients my age, have this score. I was told I am a fraction of a fraction - they don’t exist. NICE!!

I have no arthritis… aches or pains. Excellent flexibility. My skin tone fantastic. I attribute the majority of my benefit to 6 mg rapamycin weekly for the past 5 years. Now adding short cycle of HGH - one year. I am 6 months in so far.

Here are 3 years inflammation results. Very consistent.

The aging spike was when I was taking a higher rapamycin dose 10+ mg weekly for 7 months. For me more was not better! Reduced back down to 6 mg and returned to lower inflammation at 8 months.

In longevity, reduced sterile inflammation is of huge importance.

Link: Inflammation and aging: signaling pathways and intervention therapies | Signal Transduction and Targeted Therapy

Aging is characterized by systemic chronic inflammation, which is accompanied by cellular senescence, immunosenescence, organ dysfunction, and age-related diseases. Given the multidimensional complexity of aging, there is an urgent need for a systematic organization of inflammaging through dimensionality reduction.

Factors secreted by senescent cells, known as the senescence-associated secretory phenotype (SASP), promote chronic inflammation and can induce senescence in normal cells.

At the same time, chronic inflammation accelerates the senescence of immune cells, resulting in weakened immune function and an inability to clear senescent cells and inflammatory factors, which creates a vicious cycle of inflammation and senescence.

Persistently elevated inflammation levels in organs such as the bone marrow, liver, and lungs cannot be eliminated in time, leading to organ damage and aging-related diseases.

Damn… senescence and inflammation a vicious cycle.

Let’s see what happens after 6 more months of HGH. I will retest in December.

Last night at the gym.

Rocking 46 years…

[Steve_Combi]

@Beth

whatever I’m doing is working beautifully for sleep

Do you monitor your sleep in any way?

I just started doing that, mostly out of curiosity about what DSIP might do for my Deep Sleep time. I had never monitored my sleep before and sleep is one of my super powers so I was not really concerned about it. Just doing this out of curiosity.

My Deep sleep was running about 1.2 hours a night, this past week just under 2 hours a nice improvement. Total sleep is pretty consistent as we hit the hay around 10pm consistently. Same type of consistency for my REM sleep as well.

My wife always thought she was not a good sleeper and I thought so as well. BUT the watch says other wise, that she is a good sleeper with just a few more wake up than me and about 1.7 hr of deep sleep.

Knowing that has really changed her attitude about her sleep and she is now pretty happy about it.

[Beth]

@Steve_Combi, yes, I have been wearing an Oura for a few years and it has definitely helped!

For instance, when I saw what drinking did to my heart rate when I sleep, I stopped drinking … most of the time, and sigh

I had sleep issues for decades, but as a result of all the things I’ve added in the last year (thanks to all of you), now having a bad night is only 6 hours, instead of that being considered a rare excellent night!

And ha, each morning I eagerly check my Oura stats in order to know how I should feel that day !!! :).

I’m grateful each and every day that I am no longer an insomniac.

I normally get over an hour of deep sleep, but over the past two weeks I’ve had several days with only 30, and no idea why.

I’m a REM rockstar, but go figure, I recently read too much REM can be bad!!!

[AustraliaLongevity]

Damn that’s a nice stack you have there.

What is the once a week doxycycline for?

Are you still doing that testosterone face cream? Was that you who was doing that?
Since I’m using TRT cream I decided to put a tiny bit on my face daily. Unsure if that would work the same as an ester.

[Agetron]

The Doxy is in 100 mg pills take 1 every 3 days or so… to clear any bacteria, parasites and such.
Was recommended by Mikhail Blagsklonny. Been doing for at least 3 -years. Seems good. Teenagers take 100 mg daily for years to deal with acne. So my small dose is nothing.

I think the testosterone in an absorbing lotion is great for the face. Right now I have a little puffyness under my right eye. I think it is all the creatine at morning and before gym at evening and the nightly HGH past 6 months. It is a little issue - still pisses me off. lol.

See above pic.

[AustraliaLongevity]

Ever had any microbiome issues from regular doxycycline intake?

[Agetron]

Good question, but nah.

Gut health is good… take Kefir at night to wash down supplements. Daily bowel movements firm and healthy - very regular - morning and evening before gym.

[Rapan]

Switched from GH secretagogues to hGH.

After only three day of 3 IU of hGH with100mg DHEA and 1800mg Metformin and SGTL-2 inhibitor I became insulin resistant.
My fasting blood glucose went from 82 to 106.

With GH secretagogues I had no glucose/insulin issues. I changed as my IGF-1 increase was not supposed to be robust enough to stimulate thymus rejuvenation.

I will pause for now and will restart in one or two days with a higher dose of DHEA and Metformin or dosing every other day.
If this doesn’t help, I will stop. Not worth becoming diabetic.

[Agetron]

Good idea. Fahy’s protocal doses just 4 days out of a week.

I dose every day 3.3 iu and no issues. My blood results from last week… just in today. Even with 6 months of HGH 3.3 … no issues

Looks amazing.
Will share blood panel after I see my physician.

[L_H]

You may have done this, but if not - It could be worth initiating the Metformin and Sglt-2i a couple of weeks before the HGH

good luck

[LukeMV]

Do you think it’s possible your HGH might be overdosed compared to what the vial is listed at? A lot of vendors sells 10iu vials and put 12-13iu in there according to Janoshik tests.

[Rapan]

@L_H
I was on low dose Empagliflozin and Metformin before switching to hGH, but not DHEA.
Mechanism wise I don’t expect that a SGTL2 inhibitor would prevent hyperinsulinemia as it has no impact on the high free fatty acids level (FFA) in plasma induced by hGH which cause insulin resistance. With that being said I also have doubts that Metfromin+DHEA could really help blunting the effect of high FFA pressure at least not for me.

@Luke
Overdosing is always a possibilty with non pharma hGH, but even with a 20-30% higher dose I would not expect such a response, but who knows. I have no way to check the content of the vial. Measuring IGF-1 would help to understand what happened, but that’s not an option at the moment.

[touringsedan]

Also keep on mind, he states they check labs and adjust dosing. He doesn’t go into detail, but it may mean that they target an IGF range and many get a lower EOD dose.

[LukeMV]

I understand. I had a glucose at 68 last time I got labs 3 hours after my breakfast that included Acarbose so I have no issues being in that amount of HGH so your result is interesting. Keep us posted.

[Beth]

Some of you might be interested to listen to Eric Verdin’s comments on the Fahy trial

Start aprox at the 56 minute mark

359 ‒ How metabolic and immune system dysfunction drive the aging process, NAD, aging clocks, & more

[LukeMV]

This whole interview was really good

[Agetron]

I have blood panel updates after 6 months of HGH. I have been mostly concerned about diabetes from HGH… well… definitely not a problem.

Insulin is damn near perfect 4.2. DHEA must be helping.

Free testosterone looking great.

Estradiol great too.

GFR is okayyyyy… my physician started me on Jardiance - empaglifozin last night. He had a month’s worth of pharmacy samples while my prescription works through insurance. Great GP. I took first dose 25 mg last night… all good.

Empaglifozin and Canaglifozin are equivalent… just no generic canaglifozin yet… so costly.

Rapamycin/siriolimus/zydus looks good. Had taken 8 mg and tested 2.5 hours later… 3 ng/mL per 1 mg. So on target at 24 ng/mL. Proves my zydus is good. Did get clogged eye duct after this … one of my high dose side effects. Resolved in 3 days. Going back to 6 mg weekly.

Last is vitamin D… damn good . Half hour front and back in sun weekly with supplement D3 2000 iu nightly.

Complete blood work fantastic… no negative hits from HGH.

Physician report… definitely indicating much younger biological age compared to chronological age. Keep on TRT, Rapamycin and HGH.

[Jonas]

@Beth

Eric Verdin’s c

AI Summary (not fact checked):

I. The Five Horsemen of Aging

1. Original Four:

• Atherosclerotic disease (ASCVD)
• Cancer
• Neurodegenerative diseases (e.g., dementia)
• Metabolic dysfunction

2. Proposed Fifth Horseman:

• Immune system decline (immune health), due to its critical role in age-related vulnerability to infections and systemic aging.

II. Rate-Limiting Organs in Aging

1. Central Nervous System (CNS):

• Distributed influence affects all organs; aging biomarkers here predict lifespan.

2. Immune System:

• Also distributed; drives chronic inflammation (“inflammaging”) and accelerates aging.
• Key evidence: Immune-specific damage in mice (e.g., ERCC1 knockout) causes systemic aging.

III. Immune System & Aging

1. Key Challenges:

• Thymic involution reduces naïve T-cell production, impairing vaccine response in the elderly.
• Chronic inflammation is both a cause and effect of aging.

2. Interventions:

• Exercise: Enhances immune function and vaccine responsiveness.
• Rapamycin: Low-dose pulses may rejuvenate immune response (e.g., Manikkeddy trial).
• Growth hormone: Potential for thymic regeneration but risks (e.g., diabetes, cancer).

IV. Metabolism & Aging

1. Oxidative Stress:

• Inevitable due to oxygen metabolism; antioxidants failed clinically due to disrupted signaling.
• Exercise mitigates mitochondrial decline.

2. Fuel Efficiency Hierarchy:

• Cleanest fuels: Ketones > fatty acids > glucose (dirtiest due to insulin spikes and byproducts).

3. Glucose Management:

• GLP-1 agonists (e.g., tirzepatide): Improve glucose control, satiety, and metabolic markers without muscle loss.
• Diet: Minimize glucose/insulin spikes (e.g., via CGMs).

V. NAD+ & Sirtuins

1. NAD+ Decline with Age:

• Driven by increased CD38 activity (consumes NAD+) and reduced salvage pathways.

2. Supplementation Risks:

• NR/NMN may raise homocysteine (via methyl depletion) and potentially fuel cancer/SASP.
• IV NAD+ lacks evidence; converted to nicotinamide in the liver.

3. CD38 Inhibition:

• Knockout mice maintain NAD+ levels and live 15% longer, but human relevance unclear.

VI. Anti-Aging Interventions

1. Most Effective:

• Exercise: Best documented for enhancing metabolism, immunity, and longevity.

2. Pharmacological:

• Rapamycin: Extends lifespan in mice; human dosing (e.g., 5mg/week) needs refinement.
• GLP-1 agonists: Improve metabolic health; weight loss without muscle loss if combined with exercise.

3. Caution:

• Growth hormone: Mixed benefits (muscle/fat loss) vs. risks (cancer, glucose intolerance).

VII. Biomarkers & Aging Clocks

1. Challenges:

• Epigenetic clocks (e.g., Horvath, DunedinPACE) are noisy and context-dependent (e.g., immune cell shifts affect results).
• No clock yet outperforms chronological age in predicting lifespan.

2. Emerging Tools:

• Organ-specific clocks (e.g., Verdin/Tony Wyss-Coray’s proteomics): Identify “frail” organs but not clinically validated.
• Commercial tests: Unreliable; avoid those selling supplements as “solutions.”

VIII. Key Takeaways

• Priority: Optimize exercise, metabolic health (glucose/insulin control), and immune resilience.
• Caution: Supplements (e.g., NAD+ boosters) and drugs (e.g., rapamycin) need more rigorous human data.
• Holistic view: Aging involves interconnected systems (metabolism, immunity, CNS); single-target fixes are inadequate.

Conclusion: Focus on foundational practices (diet, exercise, sleep) while awaiting validated biomarkers and targeted therapies.