What is the “DAV protocol”?
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Flooshy
#43
I think Rapamycin alone is not enough.
As far as I can understand it activates autophagy throughout the body, but the body usually does not seem to prioritize repair/healing of hair because it is not essential for survival. Especially when you have chronic pain or inflammation, the body will probably focus all of its repair on essential organs and tissue.
Also keep in mind that overall health of the body matters. I think when a person’s skin and body has taken signifcant damage from the environment and aging in general, it is almost as if aging accelerates because the dysfunction of the cells cannot be repaired fast enough before new cells go dysfunctional. The probability that the body will repair the hair is extremely low the older you are and in worse shape you are.
I think the highest potential for regrowth/repigmentation is treatments that cause some kind of local hormesis. Microneedling of the scalp and applying of certain substances like Minoxidil show the most powerful changes in hair.
If you want to repigment your hair, I think you must do something to your scalp that triggers the body to repair the hair follicles. I wonder if deep needling penetration in combination with senolytics could work to make this happen but I have no idea.
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Any improvements on the grey hair matter
My main concern with super high doses of omega 3 are heart problems which seem to happen. I was doing pretty high dose for a while but just do 1 fish oil concentrate morning and one at night now.
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What I find interesting from time to time is that individual hairs will change colour part way down the hair shaft. I am mainly seeing a small number of facial hairs turning from white to pigmented. Its a small number, however.
There is one very obvious one in this photo.
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What’s your citrate dose these days?
Its around 20g per day. I should emphasise that I use a number of interventions not only citrate.
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Is enclomiphene to increase testosterone levels without shutting down HPTA?
If so, have you ever tried TRT and if so how do you compare the two?
I’ve just ordered a red light therapy cap. Been using a panel for a little while and enjoyed it so I’ve ordered cap and mask. I think that will improve circulation in the area. I use a scalp massager a few times a week.
I’ve tried many things over the years and I’ve always felt if I ever do anything that reverses gray hair I’ve discovered something that is profoundly rejuvenating unless it’s a very specific topical formula made only to reverse gray hair.
There was the case where they were testing a new anti-lung cancer drug there were consistent numbers of patients getting gray hair reversal. Given the information I’ve learned as of late of senescent cells I wonder if this was some kind of senolytic effect?
The drugs used were Nivolumab, Atezolizumab and Pembrolizumab. I would love to see these used in the Ora Biomedical C. Elegans studies.
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As far as I can see these drugs like Nivolumab, Atezolizumab and Pembrolizumab strengthen the body’s ability to detect and destroy cancer cells. In regards to hair, what could be happening is that the body’s immune system is able to detect senescent cells in the hair follicles, destroys them and replaces them with new cells.
It is most likely that hair graying is caused by senescence, accelerated through infections, stress and general inflammation. In order to reverse the loss of pigmentation, the only way I see is powerful senolytic compounds. It would probably be good to have generally very good health and no inflammation, maybe combined with local hormesis (like microneedling).
There are at least three of us in the forum that have posted pictures of the effect of rapamycin on hair pigment and new hair growth.
No, rapamycin did not completely change my hair from silver to black, but it did change enough to be noticeable. I also believe that rapamycin restores some hair in males who have genetic male-pattern baldness (me). Rapamycin produced a significant amount of new hair. Not enough to change me from bald to a full head of hair, but I started rapamycin late in life. I think that younger people taking a significant amount of rapamycin will delay turning gray and loss of hair.
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Kelman
#53
It is very subjective IMO. I haven’t seen any effect whatsoever on hair (from 2 years of Rapa use). It is not darker and it is not thicker either. Any claim that RAPA has a significant effect on hair I’d take it with a truck load grain of salt LOL. The only thing that does make a difference (pretty big one at that) is minoxidil and finasteride. Everything else I’ve tried has made no difference at all.
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Wasn’t subjective. Pictures were provided. Personally I think it is dose dependent. Two of us take high doses compared to the average rapamycin user. I would like to see if any other forum members experienced this result.
One @John_Hemming has a different protocol, and his results might be due to his other supplement intake. As I said, I don’t think rapamycin totally prevents hair loss or turns all of your hair color, but it was significant enough to be noticeable.
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There is a simple issue in that hair can get stronger, move from vellus to terminal and move from white to pigmented. That links IMO to improving mitochondrial efficiency.
I can provide photos of the individual hairs.
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LaraPo
#56
I haven’t seen any effect of Rapa on my hair. Have been on it for 16 years now.
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Kelman
#57
What you guys are seeing is normal life cycles of hair. some will fall and come out black/dark color and seeing it makes one think that the hair is changing, but it is not. Even the guy that started this thread kept saying it was rapamycin and then few months later he mentions that he’s using minoxidil and some other stuff. If you want to be subjective, put a picture of yourself before you started rapa side by side a current picture and I am almost certain that the change will either be unnoticeable or if anything your hair currently will look worse/thinner than the picture from 3-5 years ago (as result of natural aging).
IMO Rapamycin will not affect your hair for better or worse in any significant way. I can venture to say that my hair looked a bit thinner/worse because of Rapa, but then again, we are getting older (not younger LOL) so obviously it must’ve been because of the aging process. But I am 100% certain that rapa did not make any positive difference on my hair. I do however think that I have less pain and joint discomfort because of Rapa.
What has helped me with hair (maybe a bit darker, but definitely much thicker) is finasteride and minoxidil. Nothing else that I tried made a difference.
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I have previously expressed my skepticism. I don’t think rapamycin cures baldness or restores hair color to any great extent. Personally, there are too many confounding factors. I dramatically expanded my supplement list after joining the forum and seeing various studies and recommendations. Even though polypharmacy, including rapamycin, continues to increase my hair density and color. I won’t be taking my hat off in public anytime soon.
Unfortunately, I wasn’t taking any pictures of my bald head, so I don’t have any good “before” pictures of the top of my head.
@John_Hemming posted some before-and-after pictures, but he also has some confounding factors. Reverse Gray Hair, Hair Repigmentation - #89 by John_Hemming
I have just done a couple of photos of the same area as on the linked topic. It is a very slow process.
Kelman
#60
as I predicted nothing in the pics to say that Rapa is having an effect. Your hair is just normal for someone your age. Couple dark hairs here and there means nothing. If you really want thicker fuller hair, I suggest use Mino and finasteride. Clearly Rapa will not do much/anything for your hair.
