Cuff size dramatically alters bp readings. “Individuals with a wide range of arm circumferences were tested in a randomized, crossover design to compare blood pressure readings using too-small, too-large, or appropriately sized blood pressure cuffs. The authors found that for individuals with smaller arm circumferences, using a too-large (“regular”) cuff consistently underestimated systolic blood pressure (-3.6 mmHg), while for individuals with larger arm circumferences, using a too-small “regular” cuff consistently overestimated systolic blood pressure (+4.8 mmHg for “large” arms and +19.5 mmHg for “extra large” arms). These results provide further motivation for learning to measure blood pressure at home to ensure more accurate measurements than are likely to be obtained with the one-size-fits-all approach employed in many doctors’ offices.” Attias, Dec 2023
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A newly launched device:
Category: Wearable Technologies
The H2Care team developed the world’s first truly wearable blood pressure monitor.
The H2-BP is the smallest and lightest blood pressure monitor in the world that can be worn as a watch. With its own app, users can check the necessary data at any time. The H2-BP provides convenience, and a pleasing aesthetic, for a process that could be otherwise troublesome.
The wearable is Korean FDA approved and can measure blood pressure immediately in case of emergencies. Through the app, users are able to see blood pressure values measured in various forms, and they can remotely authorize users such as care providers and doctors to view stored blood pressure values as well.
In addition to blood pressure information, the H2-BP also provides activity tracking, like other activity wearables.
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LaraPo
#242
Yesterday I alternated brisk walking with jogging for 1 hour. After 1 h rest my BP fell to 107/60/50.
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… a surgical procedure called ultrasound renal denervation could safely and effectively treat hypertension
Research:
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kas
#244
I just started rapa and encountered the blood pressure spike. The first week I was on 2mg and didn’t notice any symptoms. The second week I bumped up to 5mg and 24hrs later I felt my heart pounding when doing low exertion movements (like just standing up). I checked my blood pressure and it read 180/110 (I’m normally 118/70).
The elevated aldosterone and constriction of blood vessels explanation sounds plausible to me, during the spikes when I checked my blood pressure my heart rate would spike as the monitoring cuff was relaxing and hit 100+bpm, whereas normally my resting heart rate is in the 40s. I went to the ER on the second day post taking rapa (after I recorded a 200/110 reading in the late afternoon) and they ran blood tests and EKG. Everything came back normal and within range so I was released.
The pattern I noticed was elevated blood pressure for 48-72 hours like others have mentioned. In the morning and late evening I’d see 138/80 and during mid day it spiked to 170+/100. I was in bed both days after taking rapa, didn’t eat anything or drink anything, yet the spike just suddenly appeared around noon at both the 24hr and 48hr mark (noon of each day).
At the 76hr mark from taking rapa, my blood pressure is back to 121/70 and my headache is gone.
I’m deliberating whether to continue with rapa at a much lower dose (like 1mg or so) or discontinue.
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Hi Kas, welcome to the forums. Thanks for sharing your experience. As a general strategy on dosing I think a much more cautious ramp on dosing is advisable. I started at 1mg/week for several weeks, then bumped it up to 2mg once per week for 3 weeks, then 3 mg… and have never had any issues other than a mouth sore at 5mg/week but then it went away and never had it again. See: What is the Rapamycin Dose / Dosage for Anti-Aging or Longevity?
It seems some percentage of people respond with a higher blood pressure response. Take it slow if you try again, and definitely don’t continue if you aren’t getting a positive response. As with all drugs, rapamycin probably isn’t for everyone.
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has anyone tried natto?
I saw a really scary increase in BP last week… It’s usually 100/70 but I saw it as high as 131/92 a few days ago… and 126/78 today. I did take some rapamycin with ketacon* like 1.5 weeks ago or smg and I guess I have to monitor something I’m not used to monitoring
at A4M last december i was tested low on NO. I should be getting more garlic and ginger [small amounts each time] though they aren’t easy to eat in bulk
doesn’t seem “whole enough” but might still be worth trying
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Rev. Cardiovasc. Med. 2023; 24(8): 234 Nattokinase Supplementation and Cardiovascular Risk Factors: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
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I saw a scary increase before in January 2022 - this was after a lot of nut binges, and it did go down the month after…
Over what period are you measuring BP. It can take a bit of time to settle down.
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Bicep
#248
I take that nattokinase, plus add another 2000fu to it. I don’t think it affects BP. I would say to take citrulline, eat lots of celery and avoid mouthwash. @Joseph_Lavelle had a couple episodes on this I think, and NO is a big deal.
Arginine too? Bitter melons? SOME cucumbers?
I exhausted my arginine supplement last month, evidently it didn’t really help…
Citrulline is more effective than arginine. It helps with NO production and blood flow.
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Some good information by @Ziegelhausen about how to purchase and use the Aktiia continuous blood pressure monitor from outside Europe. I think I might want to get one of these this year (and before they start selling officially in the USA).
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ken
#252
Blood pressure change after beginning taking 5 mg Rapamycin pr. week (just as RapAdmin I had a slow ramp up). There’s no real blood pressure effect on me.
I went from a monthly average of 142/92 to 137/92 (my blood presure has been too high for two years, now daily taking 100 mg Losartan Medical Valley for it, BMI 26,0)
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Hi! Did you start back up on the rapa? I have high bp also.
Low-dose mTOR inhibition by rapamycin attenuates progression in anti-thy1-induced chronic glomerulosclerosis of the rat
https://journals.physiology.org/doi/full/10.1152/ajprenal.00379.2007?utm_source=chatgpt.com
This is a low dose rapa article. Favorable. Chat at the consumer level just looks at the cancer and organ transplant cases with high rapa doses and make generalizations.
You have to specify low dose to get accurate research articles.
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ken
#255
Sorry - I wasn’t too precise (my fault)
Last summer my blood pressure was 142/92 (with the prescribed 100 mg Losartan, daily). Then I began Rapamycin 5 mg pr. week. Now 6 month later my blood pressure is 137/92 (with the prescribed 100 mg Losartan and 5 mg Rapamycin).
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That’s good to see it has gone down some in your systolic number! Those are still relatively high numbers though… Does your cardiologist know you are taking rapa? Curious to what their thoughts are.
Do you have known CAD? Do you check your glucose levels too?
Thanks! Cheers to health!!
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ken
#257
A doctor (EU Doctor) started my Rapamycin medicine cure. I did inform her about the blood pressure medicine. Over 3 month I got 3 Rapamycin prescriptions (covering half a year).
No CAD’s - all good numbers (checked every 6 months by my GP). Glycose 6,1 mmol. My cholesterol however, is too high, LDL 4,3 mmol/l (which is a pre-rapamune condition I have to work on)
I haven’t told my GP about my “dietary supplement”.
Cheers 
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Is that a fasting glucose?
ken
#259
yeah, fasting. I believe the normal band is 4-6 mmol/L (where as the non-fasting limit is 8 mmol/L). Cheers
